Projects

THE EFFECT OF DIETARY PROBIOTICS ON IMMUNE AND GASTROINTESTINAL FUNCTION Appropriated (D)   Accession Number: 408040

IMPACT OF NUTRITIONAL STATUS ON IMMUNE-INDUCED CHANGES IN GUT FUNCTION Appropriated (D)   Accession Number: 408279

MEASURING MUCOSAL DERIVED IMMUNITY IN SWINE WITH DIFFERENT VITAMIN A STATUS TO YIELD BIOMARKERS OF HUMAN NUTRIENT/DISEASE INTERACTIONS Appropriated (D)   Accession Number: 409575

EFFECT OF DIETARY INDUCED OXIDATIVE STRESS ON INTESTINAL PHYSIOLOGY AND THE DEVELOPMENT OF MUCOSAL IMMUNITY TO ENTERIC PATHOGENS Appropriated (D)   Accession Number: 408041

GENETIC AND IMMUNE STRATEGIES TO CONTROL MUCOSAL PATHOGENS OF SWINE Appropriated (D)   Accession Number: 414571

Publications

The Retinoic Acid Receptor-a Mediates Human T-Cell Activation and Th2 Cytokine Production - (Peer Reviewed Journal)

Dawson, H.D., Collins, G., Pyle, R., Key, M., Taub, D. 2008. The retinoic acid receptor-a mediates human T-cell activation and Th2 cytokine production. BioMed Central (BMC) Immunology. 169(4):16-30.

The Suitability of Swine as Models for Humans to Assess the Effect of Nutrition on Immunity - (Proceedings/Symposium)

Dawson, H.D., Reece, J.J., Chen, C.T., Urban Jr, J.F. 2008. The suitability of swine as models for humans to assess the effect of nutrition on immunity. International Symposium: Swine And Biomedical Research. p.48.

Green Tea Extract Improves the Postprandial Overproduction of Intestinal Apolipoprotein B-containing Lipoproteins in Fructose-Fed Hamsters - (Abstract)

Qin, B., Dawson, H.D., Anderson, R.A. 2008. Green Tea Extract Improves the Postprandial Overproduction of Intestinal Apolipoprotein B-containing Lipoproteins in Fructose-Fed Hamsters . BARC Poster Day.

Green Tea Extract Improves the Post Prandial Overproduction of Intestinal Apolipoprotein B-containing Lipoproteins in Fructose Fed Hamsters - (Abstract)

Qin, B., Dawson, H.D., Anderson, R.A. 2008. Green Tea Extract Improves the Post Prandial Overproduction of Intestinal Apolipoprotein B-containing Lipoproteins in Fructose Fed Hamsters. Diabetes. 57:A705.

Immortalization and Characterization of Lineage-restricted Neuronal Progenitor Cells Derived From the Procine Olfactory Bulb - (Peer Reviewed Journal)

Uebing-Czipura, U., Dawson, H.D., Scherba, G. 2008. Immortalization and characterization of lineage-restricted neuronal progenitor cells derived from the procine olfactory bulb. Journal of Neuroscience Methods. 170(2)262-276.

The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database - (Abstract)

Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database. Experimental Biology.

The Porcine Immunology and Nutrition Resource Database - (Abstract)

Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The porcine immunology and nutrition resource database. Veterinary Immunology International Symposium. p15.

A Comparative Analysis of the Porcine, Murine, and Human Immune Systems - (Abstract)

Dawson, H.D., Reece, J.J., Urban Jr, J.F. 2007. A comparative analysis of the porcine, murine, and human immune systems. Veterinary Immunology International Symposium. p.120.

Feeding Probiotic Bacteria To Swine Enhances Immunity To Ascaris Suum - (Proceedings/Symposium)

Solano Aguilar, G., Shea-Donohue, T., Madden, K., Dawson, H.D., Jones, Y., Restrepo, M.P., Beshah, E., Urban Jr, J.F. 2007. Feeding probiotic bacteria to swine enhances immunity to Ascaris Suum. Veterinary Immunology International Symposium. p.110.

Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut - (Abstract)

Reece, J.J., Kohn, K., Ets, H., Urban Jr, J.F., Dawson, H.D. 2007. Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut. BARC Poster Day.

Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet - (Peer Reviewed Journal)

Cao, H., Hininger-Favier, I., Kelly, M.A., Benaraba, R., Dawson, H.D., Coves, S., Roussel, A.M., Anderson, R.A. 2007. Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet. Journal of Agricultural and Food Chemistry. 55(15):6372-6378.

Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus - (Abstract)

Urban Jr, J.F., Smith, A.D., Botero, S., Dawson, H.D., Anthony, R., Gause, W., Shea-Donohue, T. 2007. Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus. Experimental Biology.

Green tea increases the antiinflammatory tristetraprolin and decreases the proinflammatory tumor necrosis factor mRNA levels in rats - (Abstract)

Cao, H., Kelly, M.A., Kari, F., Dawson, H.D., Coves, S., Roussel, A.M., Anderson, R.A. 2007. Green tea increases the antiinflammatory tristetraprolin and decreases the proinflammatory tumor necrosis factor mRNA levels in rats. [abstract]. Journal of Federation of American Societies for Experimental Biology. 21:358.4.

GREEN TEA INCREASES THE ANTIINFLAMMATORY TRISTETRAPROLIN AND DECREASES THE PROINFLAMMATORY TUMOR NECROSIS FACTOR mRNA LEVELS IN RATS. - (Peer Reviewed Journal)

Cao, H., Kelly, M.A., Kari, F., Dawson, H.D., Urban, Jr, J.F., Coves, S., Roussel, A.M., Anderson, R.A. 2007. Green tea increases the antiinflammatory tristetraprolin and decreases the proinflammatory tumor necrosis factor mrna levels in rats. Inflammation. 4:1-12.

Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes - (Peer Reviewed Journal)

Dawson, H.D., Collins, G., Pyle, R., Key, M., Weeraratna, A., Deep-Dixit, V., Nadal, C.N., Taub, D.D. 2006. Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BioMed Central (BMC) Immunology. 7:27.

GLUTATHIONE IS REQUIRED FOR EFFICIENT PRODUCTION OF INFECTIOUS PICORNAVIRUSES VIRIONS - (Peer Reviewed Journal)

Smith, A.D., Dawson, H.D. 2006. Glutathione is required for efficient production of infectious picornavirus virions. Electronic Virology. Available: http://www.sciencedirect.com/

A TIME COURSE STUDY OF IMMUNOLOGICAL RESPONSES IN TRICHURIS SUIS INFECTED PIGS - (Peer Reviewed Journal)

Kringel, H., Iburg, T., Dawson, H.D., Aasted, B., Roepstorff, A. 2006. A time course study of immunological responses in trichuris suis infected pigs. International Journal for Parasitology. 36(8):915-924.

BIOFIOBACTERIUM LACTIS ENHANCES TOLL-LIKE RECEPTOR (TLR) PATHWAY GENE EXPRESSION LOCALLY IN THE COLON AND ENHANCES GLUCOSE UPTAKE IN THE SMALL INTESTINE OF PIGS INFECTED WITH PARASITIC NEMATODE ASCARIS SUM. - (Proceedings/Symposium)

Solano Aguilar, G., Dawson, H.D., Shea-Donohue, T., Madden, K., Jones, Y.L., Beshah, E., Restrepo, M., Schoene, N.W., Hare Jr, W.R., Urban Jr, J.F. 2006. Biofiobacterium lactis enhances toll-like receptor (tlr) pathway gene expression locally in the colon and enhances glucose uptake in the small intestine of pigs infected with parasitic nematode ascaris sum. American Society for Microbiology Proceedings. 106:45A.

BIFIDOBACTERIUM LACTIS AFFECTS IMMUNE DEVELOPMENT OF NEONATAL PIGS: A MODEL FOR NUTRIENT CONDITIONING IN INFANTS. - (Abstract)

Solano Aguilar, G., Dawson, H.D., Jones, Y.L., Schoene, N.W., Beshah, E., Restrepo, M., Hare, W., Urban Jr, J.F. 2006. Bifidobacterium lactis affects immune development of neonatal pigs: a model for nutrient conditioning in infants. Meeting Abstract.

GENE EXPRESSION PROFILING IN SALMONELLA CHOLERAESUIS INFECTED PORCINE LUNG USING A LONG OLIGONUCLEOTIDE MICROARRAY - (Peer Reviewed Journal)

Zhao, S., Kuhar, D.J., Lunney, J.K., Dawson, H.D., Guidry, C.A., Uthe, J., Bearson, S., Recknor, J., Nettleton, D., Tuggle, C.K. 2006. Gene expression profiling in salmonella choleraesuis infected porcine lung using a long oligonucleotide microarray. Mammalian Genomics. 17:777-789.

EFFECT OF MILK SUPPLEMENTATION WITH LACTOBACILLUS BREVIS 1E1 ON JEJUNAL GENE EXPRESSION - (Abstract)

Brown, D., Davis, E., Bass, B., Lockhart, B., Rehberger, T., Solano Aguilar, G., Jones, E.A., Dawson, H.D., Maxwell, C. 2006. Effect of milk supplementation with lactobacillus brevis 1e1 on jejunal gene expression [abstract]. Federation of American Societies for Experimental Biology Conference. 20(5):A1057

FUNCTIONAL IMPORTANCE OF REGIONAL DIFFERENCES IN LOCALIZED GENE EXPRESSION OF RECEPTORS FOR IL-13 IN MURINE GUT - (Peer Reviewed Journal)

Morimoto, M., Morimoto, M., Zhao, A., Madden, K., Dawson, H., Finkleman, F., Mentink-Kane, M., Urban Jr., J.F., Wynn, T., and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology. 176(1):491-495.

INTEGRATION OF STRUCTURAL AND FUNCTIONAL GENOMICS - (Abstract)

Zhao, S., Kuhar, D.J., Recknor, J., Lunney, J.K., Nettleton, D., Dawson, H.D., Orley, S., Uthe, J., Bearson, S.M., Tuggle, C.K. 2005. Integration of structural and functional genomies. Proceedings of Integration of Structural and Functional Genomics Sympoisium 22-25 September 2005, p. 39.

PCR ANALYSES DEMONSTRATE THAT TEA INCREASES INSULIN SENSITIVITY AND INSULIN SIGNALING IN RATS WITH METABOLIC SYNDROME - (Abstract)

Anderson, R.A., Dawson, H.D., Kelly, M.A., Hiniger, I., Coves, S., and Roussel, A.M. 2005. PCR analyses demonstrate that tea increases insulin sensitivity and insulin signaling in rats with metabolic syndrome[abstract]. Polyphenols and Health. 2:14.

CAROTENOID TRANSPORT IS DECREASED AND EXPRESSION OF THE LIPID TRANSPORTERS SR-BI, NPC1L1, AND ABCA1 IS DOWNREGULATED IN CACO-2 CELLS TREATED WITH EZETIMIBE - (Peer Reviewed Journal)

During, A., Dawson, H.D., Harrison, E.H. 2005. Carotenoid transport is decreased and expression of the lipid transporters sr-bi, npc1l1, and abca1 is downregulated in caco-2 cells treated with ezetimibe. Journal of Nutrition. 22:2305-2312.

UP-REGULATION OF INFLAMMATORY, REGULATORY AND TH1-IMMUNE MARKERS IN SWINE RESPONDING TO ACUTE TOXOPLASMA GONDII INFECTION. - (Abstract)

Nishi, S.M., Dawson, H.D., Kuhar, D.J., Dubey, J.P., Urban Jr, J.F., Lunney, J.K. 2005. Up-regulation of inflammatory, regulatory and th1-immune markers in swine responding to acute toxoplasma gondii infection. Proceedings of American Association of Veterinary Parasitologists. p. 33-34.

Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects - (Proceedings/Symposium)

Kringel, H., Dawson, H.D., Urban Jr, J.F., Roepstorff, A. 2005. Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects. Proceedings of the Abildgaard Symposium. University of Life Sciences. Danish Centre for Experimental Parasitology. pp. 65-72.

IMMUNE REGULATION OF PROTEASE-ACTIVATED RECEPTOR-1 EXPRESSION IN MURINE SMALL INTESTINE DURING NIPPOSTRONGYLUS BRASILIENSIS INFECTION - (Peer Reviewed Journal)

Zao, A., Morimoto, M., Dawson, H., Elfrey, J.E., Madden, K.B., Gause, W.C., Min, B., Finkelman, F.D., Urban, J.F. Jr., Shea-Donohue, T. 2005. Immune regulation of protease-activated receptor-1 expression in murine small intestine during nippostrongylus brasiliensis infection. Journal of Immunology. 175(4):2563-2569.

MICROSOMAL ACID RETINYL ESTER HYDROLASE ISOLATION, CHARACTERIZATION, SUBSTRATE AND TISSUE SPECIFICITY - (Peer Reviewed Journal)

Linke, T.N., Dawson, H.D., Harrison, E.H. 2005. Microsomal acid retinyl ester hydrolase isolation, characterization, substrate and tissue specificity. Journal of Biological Chemistry. 280:23287-23294.

FOLLICULAR EXPRESSION OF A HUMAN BETA-CELL LEUKEMIA/LYMPHOMA-2 (BCL-2)TRANSGENE DOES NOT DECREASE ATRESIA OR INCREASE OVULATION RATE IN SWINE - (Peer Reviewed Journal)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Foster Frey, J.A., Donovan, D.M., Dawson, H.D., Welch, G.R., Garrett, W.M. 2005. Follicular expression of a human B-cell leukemia/lymphoma-2 (Bcl-2)transgene does not decrease atresia or increase ovulation rate in swine. Journal Of Reproduction, Fertility And Development. 17(4):457-468.

LOCALIZED MULTI-GENE EXPRESSION PATTERNS SUPPORT AN EVOLVING TH1/TH2-LIKE PARADIGM IN RESPONSE TO INFECTION WITH TOXOPLASMA GONDII AND ASCARIS SUUM - (Peer Reviewed Journal)

Dawson, H., Beshah, E., Nishii, S., Solano-Aguilar, G., Morimoto, M., Zhao, A. Madden, K., Ledbetter, T., Dubey, J.P., Shea-Donohue, T., Lunney, J.K., and Urban, J. F. Jr. 2005. Localized multi-gene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infection and Immunity. 73(2):1116-1128.

INCREASED TH2-ASSOCIATED IMMUNITY IN ASCURIS-INFECTED SWINE TREATED WITH RETINOIC ACID - (Abstract)

Dawson, H.D., Jones, E.A., Beshah, E., Solano Aguilar, G., Urban Jr, J.F. 2005. Increased Th2-associated immunity in ascuris-infected swine treated with retinoic acid. [abstract]. Federation of American Societies for Experimental Biology Journal. 19:A1466.

MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)

Zarlenga, D.S., Dawson, H.D., Kringel, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine IL-4 receptor and IL-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology 101(3-4):223-234.

THE EFFECT OF PROBIOTIC BACTERIA ON THE IMMUNE SYSTEM OF WEANED PIGS MONITORED BY REAL TIME PCR - (Peer Reviewed Journal)

Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Andrews, K., Harvey, R.B., Schoene, N., Urban Jr, J.F. 2004. The effect of probiotic bacteria on the immune system of weaned pigs monitored by Real time PCR. Proceedings 18th International Pig Veterinary Society Meeting, Hamburg, Germany, October 2004. p. 380.

MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)

Zarlenga, D.S., Dawson, H.D., Kringle, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine il-4 receptor and il-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology. 101(3-4):223-34 (2004)

IDENTIFICATION OF KEY IMUNE MEDIATORS REGULATING T HELPER 1 REPONSES SWINE - (Peer Reviewed Journal)

Dawson, H.D., Royaee, A.R., Nishi, S., Kuhar, D.J., Schnitzlein, W.M., Zuckermann, F., Urban, J., Lunney, J.K. 2004. Identification of key imune mediators regulating t helper 1 reponses swine. Veterinary Immunology and Immunopathology 100:105-111.

THE EFFECT OF HUMAN DERIVED PROBIOTIC BACTERIA ON THE IMMUNE AND INTESTINAL FUNCTION OF PIGS - (Abstract)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J.E., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effect of human derived probiotic bacteria on the immune and intestinal function of pigs [abstract]. Allen D. Leman Swine Conference. 30:26.

HUMAN DERIVED PROBIOTIC BACTERIA SPECIES CAN REGULATE INTESTINAL RESPONSES TO PARASITIC NEMATODES IN PIGS - (Peer Reviewed Journal)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., and Urban Jr, J.F. 2004. Human derived probiotic bacteria species can regulate intestinal responses to parasitic nematodes in pigs. Veterinary Parasitology. 125:47-161.

THE EFFECTS OF DIETARY PROBIOTICS ON IMMUNITY TO ASCARIS SUUM IN PIGS - (Abstract)

Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effects of dietary probiotics on immunity to ascaris suum in pigs [abstract]. Proceedings of American Association of Veterinary Parasitologists. Paper No. 56-54.

THE EFFECT OF DIETARY PROBIOTIC IN THE IMMUNE RESPONSE OF PIGS - (Abstract)

Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Schoene, N.W., Urban Jr, J.F. 2003. The effect of dietary probiotic in the immune response of pigs [abstract]. 9th International Symposium on Digestive Physiology in Pigs. 2:69.

CYTOKINE GENE EXPRESSION IN DAMS AND FETUSES AFTER EXPERIMENTAL NEOSPORA CANINUM INFECTION OF HEIFERS AT 110 DAYS OF GESTATION - (Peer Reviewed Journal)

Almeria, S., Demarez, T., Dawson, H.D., Araujo, R., Dubey, J.P., Gasbarre, L.C. 2003. Cytokine gene expression in dams and fetuses after experimental neospora caninum infection of Heifers at mid gestation. Parasite Immunology. vol. 25, pp. 383-92.

EXPERIMENTAL INFECTION OF PREGNANT COWS WITH NEOSPORA CANINUM: IMMUNE RESPONSES IN DAM AND FETUS. - (Abstract)

ALMERIA, S., DEMAREZ, T., DAWSON, H.D., ARAUJO, R., DUBEY, J.P., GASBARRE, L.C. EXPERIMENTAL INFECTION OF PREGNANT COWS WITH NEOSPORA CANINUM: IMMUNE RESPONSES IN DAM AND FETUS. EUROPEAN COST. p. 27, 2003.

IMMUNE RESPONSES IN DAM AND FETUS AFTER EXPERIMENTAL INFECTION OF PREGNANT COWS WITH NEOSPOTA CANINUM - (Proceedings/Symposium)

Almeria, S., Demarez, T., Dawson, H.D., Araujo, R., Padilhia, T., Dubey, J.P., Gasbarre, L.C. 2003. Immune responses in dam and fetus after experimental infection of pregnant cows with neospota caninum. Parasitology International Congress. pp. 413-18.

LIMITED EFFECT OF RECOMBINANT PORCINE INTERLEUKIN 12 ON PORCINE LYMPHOCYTES DUE TO A LOW LEVEL OF IL-12 BETA 2 RECEPTOR - (Peer Reviewed Journal)

Solano Aguilar, G., Zarlenga, D.S., Beshah, E., Gasbarre, L.C., Junker, D., Cochran, M., Dawson, H.D., Urban Jr, J.F., Lunney, J.K. 2002. Limited effect of recombinant porcine interleukin 12 on porcine lymphocytes due to a low level of il-12 beta 2 receptor. Veterinary Immunology and Immunopathology. 89:133-148 (2002)

FUNCTIONAL GENOMIC ASSESSMENT OF PORCINE DISEASE RESISTANCE: REAL TIME ASSAYS OF PORCINE IMMUNE GENE EXPRESSION - (Proceedings/Symposium)

Dawson, H.D., Nishi, S., Beshah, E., Solano Aguilar, G., Zarlenga, D.S., Urban Jr, J.F., Lunney, J.K. 2002. Functional genomic assessment of porcine disease resistance: real time assays of porcine immune gene expression. World Congress of Genetics Applied in Livestock Production #13-41.