Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • FPF
  • Familial Hibernian fever
  • FHF
  • Tumor necrosis factor receptor-associated periodic syndrome
  • TRAPS
  • Hibernian fever, familial
  • TNF receptor-associated periodic syndrome
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Periodic fever, familial, autosomal dominant
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Familial autosomal dominant periodic fever is an inherited condition characterized by episodes of fever, abdominal pain, diarrhea, painful red skin rashes, muscle pain and swelling around the eye. The former name of this syndrome was familial Hibernian fever and it is sometimes referred to as tumor necrosis factor receptor associated periodic syndrome or TRAPS.[1] Familial autosomal dominant periodic fever is caused by mutations in the Tumor Necrosis Factor Receptor gene (TNFRSF1A), which are inherited in an autosomal dominant fashion.[1][2] Although there is no proven definitive treatment to prevent or cure this condition, various anti-inflammatory agents may help to relieve symptoms. Nonetheless, most patients will experience episodes of symptoms throughout their life.[1] 

References
  1. Periodic Fever Syndromes. Cleveland Clinic Department of Rheumatic and Immunologic Diseases. 2009 Available at: http://my.clevelandclinic.org/disorders/periodic_fever_syndrome/rheumatology_overview.aspx. Accessed January 9, 2009.
  2. Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. eMedicine. November 4, 2008 Available at: http://emedicine.medscape.com/article/952254-overview. Accessed January 9, 2009.

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