Rudin C, Lauper U, Biedermann K; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 357 (abstract no. W.C.3247).
Children's Hospital, University of Basel, Basel, Switzerland
OBJECTIVE: On July 31st, 1990, the cumulative number of known children born to HIV infected mothers in Switzerland was 286. According to data of the National Neonatal HIV Study the diagnosis of HIV infection was made in 70% of the mothers during pregnancy or at birth. For that reason a complementary study was designed to obtain further epidemiologic data in HIV infected pregnant women and to look for factors during pregnancy, that may influence the outcome in the offsprings as well as interactions of pregnancy and HIV infection. METHODS: All pregnant women, known to be HIV infected and giving informed consent are enclosed. An extensive history is taken at the first visit. Blood samples for serologic and immunologic investigations are taken every three months until birth and 6 months thereafter. A thorough physical examination is performed at every visit. RESULTS: After 9 months of ongoing study 54 patients have been enclosed, including 21, who decided to terminate their pregnancies. Answers to the major issues of the study are not yet available. However we observed four women who showed an HIV seroconversion during pregnancy, one of whom passed through an acute mononucleosis-like syndrome. Two of the infants born to these mothers developed severe symptoms of HIV infection at one (wasting, encephalopathy) and three (severe thrombocytopenia) months of age. CONCLUSIONS: 1. HIV seroconversion during pregnancy is not uncommon in women with ongoing risk behaviour. A negative HIV test at the beginning of pregnancy needs to be confirmed at least once at time of delivery. 2. Our limited data probably indicate that seroconversion during pregnancy increases the risk of vertical HIV transmission, and of early disease progression in the infant.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Child
- Disease Progression
- Disease Transmission, Vertical
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Infant
- Pregnancy
- Pregnancy Complications, Infectious
- Pregnancy Outcome
- Switzerland
- transmission
Other ID:
UI: 102193324
From Meeting Abstracts