Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490
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Research Interests
- Andrew Gifford's research interests center on the neurochemistry
and behavioral pharmacology of brain cannabinoid receptors,
neuropharmacology of drugs-of-abuse, radiochemical labeling and
autoradiographic and in vivo imaging studies with neuroactive
drugs.
- Ex vivo autoradiography of brain sections from a rat injected intravenously
with the cannabinoid receptor ligand, [131I]AM2233, and sacrificed one hour later.
Radioactivity is concentrated in the regions with high receptor density.
(Figure 1)
Education & Concurrent Positions
- B.S. University of London, 1985; Ph.D. University of St. Andrews, Scotland, 1989
- Post-Doctoral Fellow, University of Texas Medical Branch, 1990-1994
- Assistant Scientist, Medical Department, BNL, 1995-1997
- Associate Scientist, BNL 97-99, Scientist, 1999-present
- Faculty Member, Graduate Program in Neurobiology and Behavior,
S.U.N.Y. at Stony Brook, 2000-present
Selected Publications
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Tovar-Salazar A., Dhawan J., Lovejoy A., Liu Q.A. and Gifford A.N.
Preparation of radioiodinated peptide nucleic acids with high specific activity.
Anal. Biochem., 360(1):92-98 (2007).
PubMed
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Dhawan J., Deng H., Gatley S.J., Makriyannis A., Akinfeleye T.,
Bruneus M., DiMaio A.A. and Gifford A.N.
Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a
radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.
Synapse, 60(2):93-101 (2006).
PubMed
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Glaser S.T., Gatley S.J. and Gifford A.N.
Ex-vivo imaging of fatty acid amide hydrolase (FAAH) activity and its inhibition in the mouse brain.
J. Pharmacol. Exp. Ther., 316(3):1088-1097 (2006).
PubMed
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Lee D.E., Gerasimov M.R., Schiffer W.K. and Gifford A.N.
Concentration dependent conditioned place preference to toluene vapors in rats.
Drug Alcohol Depend., 85(1):87-90 (2006).
PubMed
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Deng H., Gifford A.N., Zvonok A.M., Cui G., Li X., Fan P., Deschamps J.R., Flippen-Anderson J.L.,
Gatley S.J. and Makriyannis A.
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
J. Med. Chem., 48(20):6386-6392 (2005).
PubMed
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Gifford A.N., Makriyannis A., Volkow N.D. and Gatley S.J.
In vivo imaging of the brain cannabinoid receptor.
Chem. Phys. Lipids., 121(1-2):65-72 (2002).
PubMed
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Rice O.V., Gordon N. and Gifford A.N.
Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice.
Brain Res., 945(1):135-138 (2002).
PubMed
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Rice O.V., Gatley S.J., Shen J., Huemmer C.L., Rogoz R., DeJesus O.T.,
Volkow N.D. and Gifford A.N.
Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice.
Neuropsychopharmacology, 25(5):679-689 (2001).
PubMed
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Gifford A.N., Bruneus M., Gatley S.J. and Volkow N.D.
Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes.
Br. J. Pharmacol., 131(3):645-650 (2000).
PubMed
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Gifford A.N., Park M.H., Kash T.L., Herman L.M., Park E.H., Gatley S.J. and Volkow N.D.
Effect of amphetamine-induced dopamine release on radiotracer binding to D1 and D2 receptors in rat brain striatal slices.
Naunyn Schmiedebergs Arch. Pharmacol., 362(4-5):413-418 (2000).
PubMed
Last Modified: July 25, 2008
Please forward all questions about this site to:
Denise Monteleone
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