Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490
|
Research Interests
- Microbeam Radiation therapy
- Monochromatic x-ray radiography
- CT Diffraction-enhanced radiography and CT
- Avraham Dilmanian’s work focuses on the use of x-ray beams from the National
Synchrotron Light Source (NSLS) in radiation therapy and medical imaging. Microbeam
radiation therapy (MRT), which uses arrays of parallel, microplanar slices of x-ray
microbeams, each typically 50 µm thick and up to several centimeters high, typically
spaced 200 µm apart, has shown two remarkable effects on laboratory vertebrates. First,
single-fraction microbeam irradiation does not damage normal tissues at doses where
conventional broad beams produce several tissue damage. Second, single-fraction MRT kills
some types of malignant tumor models by irradiation from a single direction, at doses safe
to normal tissues. The method is being further studied for its potential in radiotherapy.
Dilmanian has been a pioneer in the filed of computed tomography (CT) using monochromatic
x rays. His current research includes, first, development of bent-crystal monochromators
for narrowing the x-ray energy spectrum in clinical angiography and CT, to be used in
conjunction with new contrast agents based on gadolinium from Schering AG, Germany.
Second, his group, together with Dr. Zhong Zhong of the NSLS, have been the first to
implement, in the CT mode, the new mammography method "Diffraction-Enhance Imaging
(DEI)". They plan to extend the method to higher-energy beams (40-100 keV) for
whole-body radiography and CT.
Education & Concurrent Positions
- B.S. Technion, Israel Institute of technology, 1970
- M.S. Technion, Israel Institute of Technology, 1973
- Ph.D. Massachusetts Institute of Technology, 1980
- Associate Scientist, Brookhaven National Laboratory, xxxx-present.
Selected Publications
-
Dilmanian F.A., Button T.M., Le Duc G., Zhong N., Peña L.A., Smith J.A.L., Martinez
S.R., Bacarian T., Tammam J., Ren B., Farmer P.M., Kalef-Ezra J., Micca P.L., Nawrocky
M.M., Niederer J.A., Recksiek F.P., Fuchs A. and Rosen E.M.
Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy.
Neuro-Oncology, 4(1):26-38 (2002).
PubMed
-
Dilmanian F.A., Morris G.M., Le Duc G., Huang X., Ren B., Bacarian T., Allen J.C.,
Kalef-Ezra J., Orion I., Rosen E.M., Sandhu T., Sathé P., Wu X.Y., Zhong
Z. and Shivaprasad H.L.
Response of avian embryonic brain to spatially segmented x-ray microbeams.
Cell. Mol. Biol., 47(3):485-493 (2001).
PubMed
-
Dilmanian F.A., Zhong Z., Ren B., Wu X.Y., Chapman L.D., Orion I. and Thomlinson W.C.
Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method.
Phys. Med. Biol., 45(4):933-946 (2000).
PubMed
-
Laissue J.A., Geiser G., Spanne P.O., Dilmanian F.A., Gebbers J.-O, Geiser M., Wu X.Y.,
Makar M., Micca P., Nawrocky M., Joel D.D. and Slatkin D.N.
Neuropathology of ablation of rat gliosarcoma and contiguous brain tissue using a microplanar beam of synchrotron- wiggler
generated x-rays.
Int. J. Cancer, 78(5):654-660 (1998).
PubMed
-
Dilmanian F.A., Wu X.-Y., Parsons E.C., Ren B., Kress J., Button T.M., Chapman L.D.,
Coderre J.A, Giron F., Greenber D., Krus D.J., Liang Z., Marcovici S., Petersen M.J.,
Roque C.T., Shleifer M., Slatkin D.N., Thomlinson W.C., Yamamoto K. and Zhong Z.
Single- and dual-energy CT with monochromatic synchrotron x rays.
Phys. Med. Biol., 42(2):371-387 (1997).
PubMed
-
Slatkin D.N., Spanne P., Dilmanian F.A., Gebbers J.-O. and Laissue J.A.
Subacute neuropathological effects on rats of microplanar beams of x rays from a synchrotron wiggler.
Proc. Natl. Acad. Sci., 92(19):8783-8787 (1995).
PubMed
-
Dilmanian F.A.
Computed Tomography with Monochromatic X Rays.
Am. J. Physiol. Imaging, 7(3-4):175-193 (1992).
PubMed
Last Modified: July 25, 2008
Please forward all questions about this site to:
Denise Monteleone
|
