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Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490

Stephen L. Dewey

Scientist


Telephone:  (631) 344-4395
e-mail:  sdewey@bnl.gov

Research Interests

  • Neurotransmitter interactions in healthy and diseased states, functional regulation of neurotransmitter systems, behavioral pharmacology and animal models of addiction, in vivo neurochemical monitoring techniques (microdialysis, PET, and microPET)

 Education & Concurrent Positions

  • B.S. Fairleigh Dickinson University, 1981
  • Ph.D. University of Iowa, 1985
  • Postdoctoral Fellow, Department of Neurology, State University of New York, Stony Brook, 1985-1986
  • Assistant Chemist, Brookhaven National Laboratory, 1986-1988
  • Associate Chemist, BNL, 1988-1991
  • Chemist, BNL, 1991-1995
  • Tenured Scientist, BNL, 1995-present
  • Senior Chemist, 1998-Present
  • Research Professor of Psychiatry, NYU School of Medicine
  • Adjunct Professor of Neurobiology and Behavior, SUNY at Stony Brook

Selected Publications

  • Schiffer W.K., Azmoodeh M.,Gerasimov M., Volkow N.D., Fowler J.S. and Dewey S.L.
    Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine.
    Synapse, 48(1):35-38 (2003).  PubMed
  • Schiffer W.K., Logan J., and Dewey S.L.
    Positron Emission Tomography Studies of Potential Mechanisms Underlying Phencyclidine-Induced Alterations in Striatal Dopamine.
    Neuropsychopharmacology, 28(12):2192-2198 (2003).  PubMed
  • Schiffer W.K., Marsteller D. and Dewey S.L.
    Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.
    Psychopharmacology (Berl), 168(3):339-343 (2003).  PubMed
  • Gerasimov M.R., Logan J., Ferrieri R.A., Muller R.D., Alexoff D., and Dewey S.L.
    Effect of vehicle on brain uptake of [11C]toluene.
    Nucl. Med. Biol., 29(5):607-612 (2002).  PubMed
  • Ashby C.R. Jr., Paul M., Gardner E.L., Gerasimov M.R., Dewey S.L., Lennon I.C. and Taylor S.J.
    Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats. Synapse, 44(2):61-63 (2002).  PubMed
  • Gerasimov M.R., Ferrieri R.A., Schiffer W.K., Logan J., Gatley S.J., Gifford A.N., Alexoff D.A., Marsteller D.A., Shea C., Garza V., Carter P., King P., Ashby C.R. Jr, Vitkun S. and Dewey S.L.
    Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice. Life Sci., 70(23):2811-2828 (2002).  PubMed
  • Gerasimov M.R., Schiffer W.K., Marstellar D., Ferrieri R., Alexoff D. and Dewey S.L.
    Toluene inhalation produces regionally specific changes in extracellular dopamine.
    Drug Alcohol Depend, 65(3):243-251 (2002).  PubMed
  • Ashby C.R., Horan B., Schiffer W.K., Brodie J.D. Dewey S.L. and Gardner E.L.
    Gamma-vinyl GABA (GVG) an irreversible inhibitor of GABA transaminase, attenuates cocaine-induced sensitization in rats.
    J. Pharm. Exp. Ther. (in press)(2001).
  • Gerasimov M.R., Schiffer W.K., Marsteller D.A., Ashby C., Gardner E.L., Lennon I.C., Taylor S., Brodie J.B., Dewey S.L.
    GABAergic blockade of cocaine-associated cue-induced increase in nucleus accumbens dopamine.
    Eur. J. Pharm., 414(2-3):205-209 (2001).  PubMed
  • Gerasimov M.R., Schiffer W.K., Marsteller D.A., Ferrieri R. and Dewey S.L.
    Psychostimulants modulate toluene’s effects on NAcc and PFC dopamine.
    Drug Alcohol Depend (in press)(2001).
  • Schiffer W.K., Gerasimov M.R., Brodie J.D., Logan J., Fowler J.S., Ashby C.R., Alexoff D.L. and Dewey S.L.
    g-vinyl GABA modulates striatal NMDA antagonist-induced dopamine release: A PET investigation in non-human primates.
    Psychopharmacology. (in press)(2001).
  • Schiffer W.K., Gerasimov M.R., Marsteller D.A., Ashby C.R., Brodie J.D. and Dewey S.L.
    Topiramate selectively attenuates nicotine-induced increases in monoamine release.
    Eur. J. Pharm. 42(3):196-198 (2001).  PubMed
  • Gerasimov M.R., Franceschi M., Volkow N.D., Rice O., Schiffer W.K. and Dewey S.L.
    Synergistic interactions between nicotine and cocaine on methylphenidate depend on the dose of dopamine transporter inhibitor.
    Synapse, 38(4):432-437 (2000).  PubMed

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Last Modified: July 25, 2008
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DOE, Office of ScienceOne of ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. Brookhaven Lab also builds and operates major scientific facilities available to university, industry and government researchers. Brookhaven is operated and managed for DOE’s Office of Science by Brookhaven Science Associates, a limited-liability company founded by Stony Brook University, the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science and technology organization.

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