The Registry of Toxic Effects of Chemical Substances

Isocyanic acid, 1,5 - naphthylene ester

RTECS #: NQ9600000

CAS #: 3173-72-6

UPDATE: May 2008 MW: 210.20 MF: C12H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,5 - Diisocyanatonaphthalene
  2. 1,5 - Naphthalene diisocyanate
  3. 1,5 - Naphthyl diisocyanate
  1. Desmodur 15
  2. Naphthalene, 1,5 - diisocyanato - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 270 mg/m3/4 hour Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0572846
inhalation
rat 		lowest published lethal concentration: 281 mg/m3/4 hour N/R ARTODN 78,243,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,303,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 71,1515,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,303,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1515,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1515,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 0.05 mg/m3 (total), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.04 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.095 mg/m3), VLE 0.02 ppm (0.19 mg/m3), FEB2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.04 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 ppm (0.017 mg/m3), ceiling concentration 0.005 ppm (0.044 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.02 mg/m3),KZG- week 0.005 ppm (0.02 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NDI-air 10 hour time-weighted average 0.04 mg/m3;
ceiling concentration 0.17 mg/m3/10 minute 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Tumorigen

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