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Summaries of Newsworthy Clinical Trial Results

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Childhood Cancer Trial Results
1.  Less-Intense Chemo Effective in Children with Intermediate-Risk Neuroblastoma
(Posted: 06/13/2007) - Infants and children with intermediate-risk neuroblastoma who received a less-intensive chemotherapy regimen had three-year overall survival rates as good as those patients in an earlier trial who received treatment that was more intensive and more toxic, according to findings presented at the 2007 ASCO meeting in Chicago.

2.  Less-Intense Chemotherapy Benefits Some Children With B-Cell Non-Hodgkin Lymphoma
(Posted: 04/25/2007) - Children and adolescents with less advanced B-cell non-Hodgkin lymphoma did just as well, and suffered fewer side effects, when treated with lower doses of multi-drug chemotherapy than is called for by the current standard of care, according to the April 1, 2007, issue of the journal Blood.

3.  Surgery May Prevent Rare Thyroid Cancer in At-Risk Children
(Posted: 09/28/2005) - Forty-four of 50 children who carried a genetic mutation that causes a rare type of thyroid cancer, but who had no symptoms of the disease, remained disease-free five or more years after preventive surgery to remove the thyroid gland, according to the Sept. 15, 2005, issue of the New England Journal of Medicine.

4.  Peer Program Helps Childhood Cancer Survivors to Quit Smoking
(Posted: 09/13/2005) - A large randomized clinical trial found that a peer-counseling approach to smoking cessation doubled the quit rate among childhood cancer survivors compared to a self-help approach, and at a relatively low cost compared to other interventions known to be successful, according to the Sept. 20, 2005, issue of the Journal of Clinical Oncology.

5.  Young Children with Medulloblastoma May Be Able to Avoid Post-Surgery Radiotherapy
(Posted: 03/21/2005) - Children younger than three with a kind of brain cancer called medulloblastoma may be effectively treated with chemotherapy alone after surgery, according to a report released by the New England Journal of Medicine on March 10, 2005.
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