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Table of Contents What is screening?
General Information About Cervical Cancer
Cervical Cancer Screening
Risks of Cervical Cancer Screening
Get More Information From NCI
Changes to This Summary (12/19/2007)
Questions or Comments About This Summary
About PDQ
What is screening?
Screening is looking for cancer before a person has any symptoms. This can help find
cancer at an early stage. When abnormal tissue or cancer is found early, it may
be easier to treat. By the time symptoms appear, cancer may have begun
to spread.
Scientists are trying to better understand which
people are more likely to get certain types of cancer. They also study the things
we do and the things around us to see if they cause cancer. This
information helps doctors recommend who should be screened for cancer, which
screening tests should be used, and how often the tests should be done.
It is important to remember that your doctor does not necessarily
think you have cancer if he or she suggests a screening test. Screening
tests are given when you have no cancer symptoms.
If a screening test result is abnormal, you may need to have more tests done to find out if you have cancer. These are called diagnostic tests.
Refer to the following PDQ summaries for information about prevention, diagnosis, and treatment of cervical cancer:
Back to Top General Information About Cervical Cancer
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Cervical cancer is a disease in which malignant (cancer) cells
form in the cervix.
The cervix is the lower,
narrow end of the uterus (the
hollow, pear-shaped organ where a fetus grows). The cervix leads from the uterus to
the vagina (birth canal).
Cervical cancer usually develops slowly over time. Before cancer
appears in the cervix, the cells of
the cervix go through changes known as dysplasia, in which cells that are not normal
begin to appear in the cervical tissue. Later, cancer cells start to grow and
spread more deeply into the cervix and to surrounding areas.
Screening for cervical cancer using the Pap test has decreased the number of new cases of cervical cancer and the number of deaths due to cervical cancer since 1950.
Cervical dysplasia occurs more often in women who are in their 20s and 30s. Death from cervical cancer is rare in women younger than 30 years and in women of any age who have regular screenings with the Pap test. The chance of death from cervical cancer increases with age. It is highest for white women between the ages of 45 and 70 years and for black women in their 70s. Deaths from cervical cancer occur more often in black women than in white women.
Human papillomavirus (HPV) infection is the major risk factor
for development of cervical cancer.
Although most women with cervical cancer have the human
papillomavirus (HPV) infection, not all women with an HPV infection will develop cervical
cancer. Many different types of HPV can affect the cervix and only some of them cause abnormal cells that may become cancer.
Some HPV infections go away without treatment. Women who do not have regular Pap
tests are at
increased risk of cervical cancer.
HPV infections are spread mainly through sexual contact. Women who become sexually active at a young age and have many sexual partners are at increased risk for HPV infections.
Other risk factors for cervical cancer include:
- Giving birth to many children.
- Having many sexual partners.
- Having first sexual intercourse at a young age.
- Smoking cigarettes.
- Using oral contraceptives ("the Pill").
- Having a weakened immune
system.
Back to Top Cervical Cancer Screening
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Tests are used to screen for different types of cancer.
Some screening tests are used because they have been shown to be helpful both in finding cancers early and in decreasing the chance of dying from these cancers. Other tests are used because they have been shown to find cancer in some people; however, it has not been proven in clinical trials that use of these tests will decrease the risk of dying from cancer.
Scientists study screening tests to find those with the fewest risks and most benefits. Cancer screening trials also are meant to show whether early detection (finding cancer before it causes symptoms) decreases a person's chance of dying from the disease. For some types of cancer, the chance of recovery is better if the disease is found and treated at an early stage.
Clinical trials that study cancer screening methods are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site.
A Pap test is commonly used to screen for cervical cancer.
A Pap test is a procedure to collect cells from the surface of the cervix and vagina. A piece of cotton, a brush, or a small wooden stick is used to gently scrape cells from the cervix and vagina. The cells are viewed under a microscope to find out if they are abnormal. This procedure is also called a Pap smear. A new method of collecting and viewing cells has been developed, in which the cells are placed into a liquid before being placed on a slide. It is not known if the new method will work better than the standard method to reduce the number of deaths from cervical cancer.
After certain positive Pap test results, an HPV DNA test may be done to find out if the HPV infection that is causing the abnormal cells is one that is linked to cervical cancer. This test can help in planning further treatment.
Other screening tests are being studied in clinical trials.
Screening clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the
NCI Web
site.
Back to Top Risks of Cervical Cancer Screening
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Screening tests have risks.
Decisions about screening tests can be difficult. Not all screening tests are helpful and most have risks. Before having any screening test, you may
want to discuss the test with your doctor. It is important to know the risks of
the test and whether it has been proven to reduce the risk of dying from cancer.
The risks of cervical cancer screening include the
following:
False-negative test results can occur.
Screening test results may appear to be normal even though cervical cancer is
present. A woman who receives a false-negative test result (one that
shows there is no cancer when there really is) may delay seeking medical care even if she has symptoms.
False-positive test results can occur.
Screening test results may appear to be abnormal even though no
cancer is present. Also, some abnormal cells in the cervix never become cancer. A false-positive test result (one that shows there is cancer when there really isn't) can cause anxiety and is usually followed by more tests and procedures (such as colposcopy, cryotherapy, or LEEP), which also have risks. The long-term effects of these procedures on fertility and pregnancy are not known.
Your doctor can advise you about your risk for cervical cancer and your need for screening tests.
Studies show that the number of cases of cervical cancer and deaths from cervical cancer are greatly reduced by screening with Pap tests. Screening should be done at least once every 2 or 3 years starting within 3 years after a woman begins to have sexual intercourse.
In women who have had a total hysterectomy (surgery to remove the uterus and cervix) for a condition that is not cancer, screening with the Pap test is not helpful. Women who are aged 60 years or older when they have a negative Pap test are very unlikely to have abnormal Pap tests on repeat screening.
The decision about how often to have a Pap test is best made by you and your doctor.
Back to Top Get More Information From NCI
Call 1-800-4-CANCER
For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 a.m. to 4:30 p.m. Deaf and hard-of-hearing callers with TTY equipment may call 1-800-332-8615. The call is free and a trained Cancer Information Specialist is available to answer your questions.
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For more information from the NCI, please write to this address:
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Search the NCI Web site
The NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support and resources for cancer patients and their families. For a quick search, use our “Best Bets” search box in the upper right hand corner of each Web page. The results that are most closely related to your search term will be listed as Best Bets at the top of the list of search results.
There are also many other places to get materials and information about cancer treatment and services. Hospitals in your area may have information about local and regional agencies that have information on finances, getting to and from treatment, receiving care at home, and dealing with problems related to cancer treatment.
Find Publications
The NCI has booklets and other materials for patients, health professionals, and the public. These publications discuss types of cancer, methods of cancer treatment, coping with cancer, and clinical trials. Some publications provide information on tests for cancer, cancer causes and prevention, cancer statistics, and NCI research activities. NCI materials on these and other topics may be ordered online or printed directly from the NCI Publications Locator. These materials can also be ordered by telephone from the Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237), TTY at 1-800-332-8615.
Back to Top Changes to This Summary (12/19/2007)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Changes were made to this summary to match those made to the health professional version.
Back to Top Questions or Comments About This Summary
If you have questions or comments about this summary, please send them to Cancer.gov through the Web site’s Contact Form. We can respond only to email messages written in English.
Back to Top About PDQ
PDQ is a comprehensive cancer database available on NCI's Web site.
PDQ is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ is available online at NCI's Web site. PDQ is provided as a service of the NCI. The NCI is part of the National Institutes of Health, the federal government's focal point for biomedical research.
PDQ contains cancer information summaries.
The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries are available in two versions. The health professional versions provide detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions provide current and accurate cancer information.
The PDQ cancer information summaries are developed by cancer experts and reviewed regularly.
Editorial Boards made up of experts in oncology and related specialties are responsible for writing and maintaining the cancer information summaries. The summaries are reviewed regularly and changes are made as new information becomes available. The date on each summary ("Date Last Modified") indicates the time of the most recent change.
PDQ also contains information on clinical trials.
A clinical trial is a study to answer a scientific question, such as whether a method of finding cancer earlier can help people to live longer. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients and those who are at risk for cancer. During screening clinical trials, information is collected about the effects of a new screening method and how well it works. If a clinical trial shows that a new method is better than one currently being used, the new method may become "standard." People who are at high risk for a certain type of cancer may want to think about taking part in a clinical trial.
Listings of clinical trials are included in PDQ and are available online at NCI's Web site. Descriptions of the trials are available in health professional and patient versions. Many cancer doctors who take part in clinical trials are also listed in PDQ. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.
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