Testing Status of Agents at NTP
Asphalt Table 9
Table 9. Incidence and types of tumors induced in C3H/HES mice treated dermally with roofing asphalt fume condensatesa.
| Final Histopathology | ||||||
|---|---|---|---|---|---|---|
| Tumor-bearing animals | Tumors | |||||
| Material Tested | Sunlight | Benign | Malignant | Papilloma | Squamous Cell Carcinoma | Totalb |
| Type I asphalt @ 232°C | - | 24 | 22 | 34 | 26 | 76 |
| + | 14 | 27 | 22 | 25 | 62 | |
| Type I asphalt @ 316°C | - | 13 | 31 | 27 | 31 | 78 |
| + | 18 | 26 | 36 | 26 | 73 | |
| Type III asphalt @ 232°C | - | 15 | 25 | 32 | 19 | 66 |
| + | 11 | 20 | 14 | 19 | 54 | |
| Type III asphalt @ 316°C | - | 12 | 28 | 24 | 36 | 82 |
| + | 20 | 18 | 34 | 20 | 65 | |
| B(a)P | - | 11 | 27 | 12 | 29 | 53 |
| + | 7 | 27 | 11 | 22 | 43 | |
| Cyclohexane/acetone | - | 0 | 0 | 0 | 0 | |
| + | 1 | 0 | 2 | 2 | ||
a Adapted from Thayer et al. [1981].
b Other tumor types observed included: fibrosarcomas, kerato-acanthomas, fibromas, and unclassified benign
epitheliomas.
Web page last updated on August 15, 2005
