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Testing Status of Agents at NTP
Testing Status of Agents at NTP
Home » Testing Information » Testing Status of Agents at NTP » Asphalt Fumes » Asphalt Table 12
Table 12. Induction of histopathologically-confirmed carcinomas in C3H/HeJ and Sencar mice
Mouse strain | Substance painted on mouse skin | Number of histopathologically confirmed malignant tumors/grp | Number of histopathologically confirmed malignant tumors | Average time (weeks) to carcinoma |
---|---|---|---|---|
C3H/HeJ mice | Raw asphalt | 3 | 3 | 101.3 |
Neat asphalt fume | 25 | 20 | 73.9 | |
Fraction B | 10 | 10 | 98.3 | |
Fraction C | 18 | 17 | 85.6 | |
Fractions A, B, C, D, E (combined) | 23 | 19 | 75.4 | |
Fractions A, B (combined) | 8 | 8 | 11.4 | |
Fractions A, C (combined) | 16 | 11 | 89.6 | |
Fractions B, C, D, E (combined) | 18 | 15 | 80.7 | |
Fractions A, B, C, D (combined) | 22 | 18 | 80.0 | |
Fractions A, B, C, E (combined) | 30 | 21 | 77.4 | |
Fractions B, C, D (combined) | 22 | 15 | 86.4 | |
Fractions B, C (combined) | 26 | 24 | 73.4 | |
Fractions A, C, D, E (combined) | 14 | 14 | 88.6 | |
Fractions A, B, D, E (combined) | 7 | 7 | 97.3 | |
0.01% BaP | 28 | 27 | 55.9 | |
0.001% BaP | 3 | 3 | 102.7 | |
Fraction A + 0.01% BaP | 28 | 23 | 69.4 | |
Fraction A + 0.001% BaP | 1 | 1 | 105.6 | |
Fraction A + 0.0001% BaP | 1 | 1 | 106.0 | |
Fraction D + 0.01% BaP | 34 | 25 | 63.6 | |
Fraction D + 0.0001% BaP | 1 | 1 | 105.6 | |
Fraction E + 0.01% BaP | 23 | 23 | 61.3 | |
Fraction E + 0.001% BaP | 2 | 2 | 105.6 | |
Solvent control | 0 | 0 | Not applicable | |
Sencar mice | Neat asphalt fume | 18 | 14 | 82.6 |
Solvent control | 0 |
Thirty mice tested per group.
Web page last updated on August 15, 2005
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.