Testing Status of Agents at NTP
Asphalt Table 10
Table 10. Incidence and types of tumors induced in CD-1 mice treated dermally with roofing asphalt fume condensatesa.
Final Histopathology | ||||||
---|---|---|---|---|---|---|
Tumor-Bearing Animals | Tumors | |||||
Material Tested | Sunlight | Benign | Malignant | Papilloma | Squamous Cell Carcinoma | Totalb |
Type I asphalt @ 232°C | - | 6 | 0 | 12 | 0 | 12 |
+ | 2 | 0 | 3 | 0 | 3 | |
Type I asphalt @ 316°C | - | 13 | 1 | 18 | 0 | 19 |
+ | 3 | 0 | 3 | 0 | 3 | |
Type III asphalt @ 232°C | - | 9 | 1 | 11 | 1 | 13 |
+ | 5 | 2 | 5 | 1 | 7 | |
Type III asphalt @ 316°C | - | 13 | 3 | 17 | 1 | 20 |
+ | 4 | 1 | 5 | 1 | 6 | |
B(a)P | - | 24 | 11 | 43 | 10 | 58 |
+ | 9 | 3 | 11 | 1 | 18 | |
Cyclohexane/acetone | - | 0 | ||||
+ | 0 |
a Adapted from Thayer et al. [1981].
b Other tumor types observed included: fibrosarcomas, kerato-acanthomas, fibromas and unclassified benign epitheliomas.
Web page last updated on August 15, 2005