Salmon D, Lewden C, Heripret L, Bonnet F, Bevilacqua S, Costagliola D, May T, Morlat P, Chene G; Conference on Retroviruses and Opportunistic Infections (11th : 2004 : San Francisco, Calif.).
Program Abstr Conf Retrovir Oppor Infect 11th 2004 San Franc Calif. 2004 Feb 8-11; 11: abstract no. 798.
CHU Cochin, Paris, France
BACKGROUND: The aim of this study was to compare the proportion of deaths due to end stage liver disease (ESLD) in HIV-infected patients depending on viral hepatitis co-infection.METHODS: All cases of death occurring in 2000 were prospectively notified in 185 French hospitals wards, involved in the management of HIV infection. Underlying causes of death were determined from standardized questionnaires. Patients with a documented serostatus for both HCV and HBV were classified into 4 groups: HCV alone (positive HCV serology), HBV alone (positive HbsAg), HCV, and HBV, not infected with HCV or HBV.RESULTS: Among the 822 patients with a documented serostatus for HCV and HBV, 29% were HCV co-infected, 8% were HBV co-infected, and 4% were co-infected with both HCV and HBV. Among HCV co-infected patients, ESLD was a more frequent underlying cause of death (31%) than AIDS (29%). Among HBV-co-infected patients, ESLD was a less frequent underlying cause of death (22%) than AIDS (38%). The proportion of deaths from ESLD was the highest among patients co-infected with both HCV and HBV reaching 44% of the causes of death. Among those who died from ESLD, a hepatocarcinoma was present in 11% of the deaths. Among the entire population, patients who died from ESLD had a relatively immunological condition: 43% of the deaths had a CD4 cell count >200/mm3 as compared with 27% only for patients who died from another cause.CONCLUSIONS: ESLD is the leading cause of death in patients co-infected by HCV and in patients co-infected with both HCV and HBV. The development of therapeutic strategies aimed to eradicate or inhibit viral replication of those viruses or to slow the progression of fibrosis are urgently needed in these patients.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Death
- Disease Progression
- HIV
- HIV Infections
- HIV Seropositivity
- Hepacivirus
- Humans
- Liver Diseases
Other ID:
UI: 102270987
From Meeting Abstracts