Carosi G, Castelli F, Forleo MA, Gussago A, Bianchini G, Zanetti AR, Soresina AR, Padula D, Duse M; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B203 (abstract no. PoB 3677).
Mother & Child Dpt, Brescia, Italy.
OBJECTIVES: To evaluate diagnostic & prognostic predictive value of clinical & viro-immunological markers in children born to HIV+ mothers. METHODS: A series of 47 consecutive children born to HIV seropositive mothers has been monitored since birth with quarterly clinical and laboratory check-ups. PCR using non isotopic probes has been performed on a sample from each CDC class at 3 and 6 months of age. RESULTS: At January 31, 1992, 27 seroconverted, 13 still have indeterminate infection (P0), 3 have asymptomatic infection (P1) and 4 have undergone clinical disease (P2) (3 of which died), transmission rate being 20.6% (7/34) Some clinical (hepatomegaly, lymphoadenopathy, oral candidiasis) and laboratory (ESR, IgG, IgA, CD4 count) markers showed early diagnostic predictive value, alone and/or in association, which allowed diagnosis of infection in 6/7 infected children before serological or virological confirmation. All PCR tested seroconverted cases (n. 9) gave PCR negative results at 3 and 6 month of age. All the 5 children who gave PCR pos. results have later developed evidence of infection (actually P1 or P2). Four PCR neg and 2 PCR pos children still have no clinical, serological nor immunological evidence of infection (P0). DISCUSSION: Our data suggest that a careful evaluation of a combination of clinical and viro-immunological parameters allows early diagnosis in a high proportion of HIV infected children. Nevertheless, PCR proved to be a more sensitive tool in early diagnosis of vertically acquired HIV infection.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Child
- HIV Infections
- HIV Seropositivity
- Humans
- Polymerase Chain Reaction
- diagnosis
- psychology
Other ID:
UI: 102199114
From Meeting Abstracts