VI. Preparing a Revision Clinical Research Center Grant Application

A revision application may be submitted only to request support for the continuation of subprojects originally recommended for a period shorter than the parent grant. Requested project periods may not exceed the time remaining on the parent grant.

Potential applicants for a revision to a Clinical Research Center grant (P50) are urged to consult with NIDCD program staff before beginning an application. NIDCD staff will determine whether the planned project appears to be appropriate as a revision to an existing P50. NIDCD staff will offer advice and suggestions to the principal investigator during the application and review process. Program staff are listed by program area in this document under Section V, Staff Consultation

Preparing an Application for a Revision
Since the grant application upon which the revision request is developed is available only as a resource document during the merit review, the existing parent program must be described in sufficient detail to allow adequate evaluation of the revision application. The overall format and content of the revision application must conform to the instructions provided in the applicable preceding sections of these Guidelines. The same review criteria described above will be applied to applications for revisions.

Face Page
In preparing a revision application, type "CLINICAL RESEARCH CENTER GRANT (P50) REVISION" in the top left-hand corner of the face page immediately above the words "Department of Health and Human Services." Line 1 should be the title of the parent grant, and line 3 should be the name of the Principal Investigator of the parent grant.

Abstract
On page 2 of the Application Form PHS 398, provide a brief description of the entire program in addition to a summary of the revision request.

Budget
Refer to the section on the preparation of the budget that is presented in the main section of these Guidelines. For each subproject or core unit in the revision request, prepare the standard "Detailed Budget for First 12-Month Budget Period" and the "Budget for Entire Proposed Project Period." Update the originally submitted "Person Month Distribution among Projects and Core Units" (Section VIII, Illustration 3), to include the revision component(s) requested. Budget periods must conform to the parent grant and the duration of the revision cannot extend beyond the parent grant.

When appropriate, provide brief explanations, in tabular form, of any changes in the budgets of the subprojects and core units since the last competitive review. In particular, note and explain any rebudgeting of funds between subprojects and core units.

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