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I. Overview


These guidelines supersede all prior guidelines for the NIDCD Clinical Research Center Grants (P50). Additional information may be obtained from NIDCD staff listed under Staff Contacts or may be found on the NIDCD grants homepage.

The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human communication disorders. The NIDCD believes that most research within its mission areas can be best accomplished via the investigator-initiated individual research grant (R01) and the research core center grant (P30) mechanisms. There are special circumstances in clinical research however, that warrant use of the P50 mechanism to support clinical research. Clinical Research is defined as research involving individuals with communication disorders or data/tissues from individuals with a communication disorder. Examples of such research include but are not limited to, studies of the prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language.

Potential applicants for Clinical Research Center Grants (P50) should consult with NIDCD program staff during the early planning stages of preparing an application. This will help potential applicants determine whether the planned project is appropriate for the P50 mechanism and gather other advice that may be useful during the application and review process.

Applicants planning to submit an investigator-initiated new (type 1), renewal (type 2/competing continuation), revision (type 3), or any resubmission (amended/revised version) of the preceding grant application types requesting $500,000 or more in direct costs for any year must obtain prior approval from NIDCD at least 6 weeks prior to date of submission. Applicants must identify the staff member who agreed to accept assignment of the application, in a cover letter sent with the application. Refer to Program contacts are listed by program area at the end of this document under Staff Consultation. For general P50 information, please contact Dr. Lana Shekim at

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National Institute on Deafness and Other Communication Disorders. Celebrating 20 years of research: 1988 to 2008