« Factbook Table of
Contents
2. Program Overview
The National Heart Institute (NHI) was established in
1948 through the National Heart Act with a mission to support research and
training in the prevention, diagnosis, and treatment of cardiovascular diseases
(CVD). Twenty-four years later, through section 413 of the National Heart,
Blood Vessel, Lung, and Blood Act (P.L. 92-423), Congress mandated the
Institute to expand and coordinate its activities in an accelerated attack
against heart, blood vessel, lung, and blood diseases. The renamed National
Heart, Lung, and Blood Institute (NHLBI) expanded its scientific areas of
interest and intensified its efforts related to research on diseases within its
purview. Over the years, these areas of interest have grown to encompass
genetic, genomic, and proteomic research, systems biology, sleep disorders, and
the Women's Health Initiative (WHI).
The mission of the NHLBI is to provide leadership for
a national program in diseases of the heart, blood vessels, lung, and blood;
sleep disorders; and blood resources management. The Institute:
- Plans, conducts, fosters, and supports an
integrated and coordinated program of basic research, clinical investigations
and trials, observational studies, and demonstration and education projects
related to the causes, prevention, diagnosis, and treatment of heart, blood
vessel, lung, and blood diseases and sleep disorders conducted in its own
laboratories and by other scientific institutions and individuals supported by
research grants and contracts.
- Plans and directs research in development and
evaluation of interventions and devices related to the prevention of heart,
lung, and blood diseases and sleep disorders and the treatment and
rehabilitation of patients who suffer from them.
- Conducts research on the clinical use of blood and
all aspects of the management of blood resources.
- Supports career training and development of new and
established researchers in fundamental sciences and clinical disciplines to
enable them to conduct basic and clinical research related to heart, blood
vessel, lung, and blood diseases; sleep disorders; and blood resources through
individual and institutional research training awards and career development
awards.
- Coordinates relevant activities with other research
institutes and all Federal health programs in the above areas, including the
causes of stroke.
- Conducts educational activities, including
development and dissemination of materials for health professionals and the
public in the above areas, with emphasis on prevention.
- Maintains continuing relationships with
institutions and professional associations, and with international, national,
state, and local officials, as well as voluntary agencies and organizations
working in the above areas.
- Oversees management of the WHI.
Each year, the NHLBI assesses progress in the
scientific areas for which it is responsible and updates its goals and
objectives. As new opportunities are identified, the Institute expands and
revises its areas of interest. Throughout the process, the approach used by the
Institute is an orderly sequence of research activities that includes:
- Acquisition of knowledge
- Evaluation of knowledge
- Application of knowledge
- Dissemination of knowledge.
In 2007, the NHLBI released the Strategic Plan: A
Scientific Blueprint for the Next Decade, which is intended to guide the
Institute in its research and training programs over the next 5 to 10 years.
Its goals reflect the successive movement of scientific discovery from "form to
function," "function to causes," and "causes to cures." They focus on questions
and processes that are broadly applicable to the Institute's mandate, rather
than on any specific disease or condition. The goals are:
- To increase understanding of the molecular and
physiological basis of health and disease and use that understanding to improve
diagnosis, treatment, and prevention.
- To improve understanding of the clinical mechanisms
of disease and thereby enable better prevention, diagnosis, and treatment.
- To translate research into practice for the benefit
of personal and public health.
During the past year, the Institute continued to
restructure its organization to improve the Institute's ability to serve as an
international leader through support of innovative research in heart, lung,
blood, and sleep research. The reorganization strengthened scientific
coordination by seeking specialized depth in specific disease areas,
integrating basic research and clinical trials components, emphasizing
prevention, and fostering population sciences.
Education outreach was a major area to undergo
reorganization. Through the Office of Prevention, Education, and Control
(OPEC), the NHLBI has had a long history of establishing and maintaining
educational outreach programs to fulfill its Congressional mandate to translate
and disseminate science-based information to professional, patient, and public
audiences. In an effort to enhance the visibility and effectiveness of this
mandated function, the NHLBI Director established the Division for the
Application of Research Discoveries (DARD), replacing the OPEC. The DARD
provides leadership for the vigorous pursuit of excellence in national and
international research translation, dissemination, and utilization programs to
speed the application of scientific advances in prevention, detection, and
treatment of cardiovascular, lung, and blood diseases and to reduce the
discoverydelivery gap. Through knowledge networks, education programs,
community outreach, conferences, and symposia, the DARD fosters communication
and collaboration among researchers, clinical and public health practitioners,
patients, and the general public.
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NHLBI Programs
The programs of the NHLBI, as shown on page 9, are
implemented through five extramural units:
- Division of Cardiovascular Diseases (DCVD)
- Division of Lung Diseases (DLD)
- Division of Blood Diseases and Resources
(DBDR)
- Division of Prevention and Population Sciences
(DPPS)
- Division for the Application of Research
Discoveries
and one intramural unit:
- Division of Intramural Research (DIR)
The extramural divisions use a variety of funding
mechanisms, such as research grants, cooperative agreements, program project
grants, Small Business Innovation Research (SBIR) grants, Small Business
Technology Transfer (STTR) grants, Specialized Centers of Research (SCOR) and
Specialized Centers of Clinically Oriented Research (SCCOR) grants,
comprehensive center grants, contracts, and research training and career
development programs.
Descriptions of the Divisions follow.
Division of Cardiovascular
Diseases
The DCVD provides leadership for a national and
international extramural program in CVD that integrates basic science and
clinical research, including translational research, networks, and multicenter
clinical trials. It designs, conducts, supports, and oversees research on the
causes and prevention and treatment of diseases and disorders such as
atherothrombosis, coronary artery disease, myocardial infarction and ischemia,
heart failure, arrhythmia, sudden cardiac death, adult and pediatric congenital
heart disease, cardiovascular complications of diabetes and obesity, and
hypertension. It also supports and oversees research in vascular medicine and
biology and valvular, cerebral, renal, peripheral, and other cardiovascular
disorders. The DCVD fosters biotechnological research in genomics, proteomics,
nanotechnology, imaging, device development, cell- and tissue-based
therapeutics, and gene therapy and in their uses as they relate to CVD. It also
supports training and career development programs in cardiovascular research at
all educational levels from high school students to academic faculty, including
programs for individuals from diverse populations. SCCORs support clinical
collaborative research in cardiac dysfunction and disease; pediatric heart
development and disease; and vascular injury, repair, and remodeling.
Programs Supported by the
National Heart, Lung, and Blood Institute |
Advanced Technologies and
Surgery Diagnostics Development Emerging Therapeutics
Enabling Technologies Surgery Advances
Atherothrombosis and Coronary Artery
Disease Acute and Chronic Coronary Syn-dromes Acute and
Silent Ischemia Angina Atherothrombosis Coronary Artery Disease
Myocardial Infarction Revascularization
Heart Developmental and Structural
Disease Adult Congenital Disease Cardiac Immunology and
Infection Cardiovascular Development Heart Transplantation
Pediatric Cardiovascular Disease Valvular Heart Disease
Heart Failure and
Arrhythmias Arrhythmias Heart Failure Myocardial
Protection Resuscitation Sudden Cardiac Death
Vascular Biology and
Hypertension Aneurysms Cerebrovascular Disease
Hypertension Lymphatic Diseases Peripheral Vascular Disease Renal
Vascular Disease Vascular Biology Vascular Development and
Angiogenesis |
Airway Biology and
Disease Asthma Chronic Obstructive Pulmonary Disease
(COPD) and Environmental Lung Diseases Cystic Fibrosis (CF) Genetics,
Genomics, and Biotechnology
Lung Biology and
Disease Acquired Immunodeficiency Syndrome (AIDS) and
Tuberculosis (TB) Critical Care and Acute Lung Injury Developmental
Biology and Pediatric Lung Disease Immunology and Fibrosis Lung Cell
and Vascular Biology
National Center on Sleep Disorders
Research Sleep Disorders and Related Conditions
Blood Diseases
and Resources |
Blood Diseases
Anemias Erythropoiesis Malaria Red Cells Sickle Cell Disease
(SCD) Thalassemia
Thrombosis and
Hemostasis Hematologic Immune Disorders Hemophilia and
Other Bleeding Disorders Hemostasis Immunity and
Inflammation Thrombosis
Transfusion Medicine and Cellular
Therapeutics Hematopoietic Stem Cell Transplantation
Immune Deficiencies, Reconstitution, Response, and Tolerance
Myelodysplasia, Marrow Failure, and Myeloproliferative Disorders Novel
Cellular Therapies for Repair and Regeneration Stem Cell Biology
Transfusion Medicine Use, Safety, and Availability of Blood and Blood
Components |
Prevention and
Population Sciences |
Clinical Applications and Prevention
Behavioral Medicine and Prevention Clinical Prevention
and Translation
Epidemiology Analytical
Resources Field Studies and Clinical Epidemiology Genetic
Epidemiology
Womens Health Initiative
Hormone Therapy Trial Dietary Modification Trial Calcium
and Vitamin D Trial Observational Study
Application of
Research Discoveries |
Research Translation Branch
Research Translation Research Opportunities
Identification Clinical Guidlines Clinical Support and Implementation
Applications Knowledge Exchange Networks
Enhanced Dissemination and
Utilization Branch Reseach Dissemination Research
Utilization Data Analysis and Evaluation
Health Communications and Social
Marketing Branch Health Communication Strategies Social
Marketing Media Relations NHLBI Health Information Center
Clinical Research
Cardiothoracic Surgery Hematology Pulmonary and Vascular Medicine
Translational Medicine
Laboratory Research
Biochemistry and Biophysics Cell Biology and
Physiology Genetics and Development Biology Immunology |
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The Division is organized into the five branches and
one office described below.
Advanced Technologies and Surgery Branch
The Advanced Technologies and Surgery Branch conducts
and manages an integrated basic and clinical research program to study
innovative and developing technologies for the diagnosis, prevention, and
treatment of CVD. It promotes opportunities to translate promising scientific
and technological advances from discovery through preclinical studies to
clinical trials. The Branch supports the following areas:
- Diagnostics: proteomic, genomic, and other
biomarker technologies and imaging modalities/agents to identify CVD and guide
therapy.
- Therapeutics: tissue-, cell-, and gene-based
therapies; regenerative and reparative medicine; image-guided therapies; and
devices for circulatory and cardiac support and repair.
- Surgery: improved surgical and image-guided
approaches and evidence-based clinical research to advance promising new
cardiovascular therapies, technologies, and surgical practices into clinical
use.
- Enabling Technologies: bioinformatics,
computational and systems biology, bioengineering, nanotechnology, materials
research, and personalized medicine.
Atherothrombosis and Coronary Artery Disease
Branch
The Atherothrombosis and Coronary Artery Disease
Branch conducts and manages an integrated basic and clinical research program
to study the etiology, pathogenesis, prevention, diagnosis, and treatment of
coronary artery disease and atherothrombosis. It promotes opportunities to
translate promising scientific and technological advances from discovery
through preclinical studies to networks and multisite clinical trials. The
Branch supports the following areas:
- Atherothrombosis: initiation, progression, and
regression of atherosclerotic lesions in coronary arteries and other arterial
beds; lesion instability and thrombosis; risk factor mechanisms; interaction of
lipid fractions and other systemic and humoral factors with the arterial wall;
biomarker and imaging diagnostics to quantify atherosclerotic disease and its
progression; vulnerable plaques and vulnerable patients; and diabetes, obesity,
other metabolic disorders, and diet and exercise related to
atherothrombosis.
- Coronary Artery Disease: acute and chronic coronary
syndromesincluding myocardial infarction, acute ischemia and related
events, angina, and silent ischemiaand percutaneous and surgical
revascularization of stenotic and restenotic coronary lesions.
Heart Development and Structural Diseases Branch
The Heart Development and Structural Diseases Branch
conducts and manages an integrated basic and clinical research program to study
normal and abnormal cardiovascular development. It also oversees research
related to the etiology, pathogenesis, prevention, diagnosis, and treatment of
pediatric and adult structural heart disease. Within the NHLBI and the NIH, the
Branch is a focal point for coordination of activities and development of
educational materials related to clinical research on pediatric CVD. It
promotes opportunities to translate promising scientific and technological
advances from discovery through preclinical studies to network and multisite
clinical trials. The Branch supports the following areas:
- Heart Development: normal and abnormal
cardiovascular development, molecular and genetic etiology of cardiovascular
malformations, cardiomyogenic differentiation of stem cells, and
geneenvironment interactions in development of congenital heart
disease.
- Structural Disease: congenital heart disease from
embryology through adulthood, valve disease and determinants of degeneration,
myocardial response to valvular disease, neurodevelopmental outcome in
congenital heart disease, exercise physiology in congenital heart disease,
pediatric cardiomyopathy and heart transplantation, and pediatric cardiac
inflammation and infection.
Heart Failure and Arrhythmias Branch
The Heart Failure and Arrhythmias Branch conducts and
manages an integrated basic and clinical research program to study normal
cardiac function and pathogenesis to improve diagnosis, treatment, and
prevention of heart failure and arrhythmias. It promotes opportunities to
translate promising scientific and technological advances from discovery
through preclinical studies to multisite and network clinical trials. The
Branch supports the following areas:
- Heart Failure: devices and medical and cell-based
therapies targeting heart failure, myocardial protection, and pathogenesis and
treatment of heart failure and cardiomyopathies.
- Arrhythmias: arrhythmogenesis, genetic and
environmental bases of normal cardiac electrical activity and arrhythmias,
etiology of rare and common arrhythmias, and sudden cardiac death.
- Myocardial Protection: myocardial preconditioning,
amelioration and prevention of myocardial stunning and hibernation, and
protection from ischemic/reperfusion injury.
- Resuscitation Science: mechanisms and management of
clinical and experimental pathophysiologic states of whole body oxygen
deprivation; systemic hypovolemia and resulting multiorgan failure; organ
preservation; and cell, tissue, and organ protection during cardiac arrest and
traumatic shock.
Vascular Biology and Hypertension Branch
The Vascular Biology and Hypertension Branch conducts
and manages an integrated basic and clinical, extramural, research program to
investigate vascular biology and the etiology, pathogenesis, prevention,
diagnosis, and treatment of hypertension and vascular diseases. It promotes
opportunities to translate promising scientific and technological advances from
discovery through preclinical studies to networks and multisite clinical
trials. The Branch supports the following areas:
- Vascular Biology: biology of the vascular wall;
vascular biology (related to hypertension; cerebrovascular, renal, and
peripheral vascular disease; aneurysms; and lymphatic diseases); development of
arteries, veins, lymphatics, and microcirculation; and angiogenesis.
- Vascular Medicine: aneurysms and cerebrovascular,
renal, and peripheral vascular disease.
- Hypertension: blood pressure regulation including
central, renal, and vascular control and cerebrovascular disease resulting from
high blood pressure.
Office of Research Training and Career
Development:
The Office of Research Training and Career Development
supports training and career development programs in cardiovascular research,
offering opportunities to individuals at all educational levels from high
school students to academic faculty, including programs for individuals from
diverse populations. The programs promote opportunities for investigators
who are early in their research careers and under mentorship from senior
scientists to perform basic, preclinical, or clinical cardiovascular
research and to take emerging and promising scientific and technological
advances from discovery through preclinical and clinical studies. The Office
also collaborates with the scientific community and professional organizations
to ensure that training programs meet the current and future needs of the
cardiovascular research workforce. The Office supports the following
programs:
- Institutional and individual research training
programs and fellowships for training of promising cardiovascular scientists at
the predoctoral, postdoctoral, junior faculty, and established investigator
levels.
- Diversity supplements to ongoing research grants
for support of young investigators from diverse backgrounds, from the high
school to the junior faculty level.
- The Pathway to Independence Program, which allows
the recipient to bridge the gap between a career development award and a
research award.
- Career development programs specifically designed
for clinical research or for minority researchers and institutions.
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Division of Lung Diseases
The DLD plans and directs a coordinated research
program on the causes, progression, diagnosis, treatment, and prevention of
lung diseases and sleep disorders. It supports basic research, clinical trials,
national pulmonary centers, technological development, and application of
research findings. The Division focuses on the biology and function of the
respiratory system, fundamental mechanisms associated with specific pulmonary
disorders, and development of new treatment strategies for patients. SCORs
support collaborative studies on airway biology and pathogenesis of CF and
neurobiology of sleep and sleep apnea. SCCORs support collaborative studies on
translational research in acute lung injury, COPD, pulmonary vascular disease,
and host factors in chronic lung diseases.
The Division also supports (a) demonstration and
dissemination projects to transfer basic research and clinical findings to
health care professionals and patients and (b) training and career development
programs for individuals interested in furthering their professional abilities
in lung diseases research. The DLD, through the National Center on Sleep
Disorders Research, coordinates sleep research activities across NIH, other
Federal Agencies, and outside organizations.
The Division is organized into the three major
branches described below.
Airway Biology and Disease Branch
The Airway Biology and Disease Branch supports
research and research training in asthma, COPD, CF, and airway function in
health and disease. Basic research focuses on elucidating the genetics,
etiology, and pathophysiology of the diseases. Clinical studies focus on
improving asthma management; reducing health disparities in asthma; improving
COPD treatment and management; and developing genetic, pharmacologic, and
nonpharmacologic (e.g., gene transfer) treatments for CF.
Lung Biology and Disease Branch
The Lung Biology and Disease Branch supports research,
education, and training programs in lung cell and vascular biology;
developmental biology and pediatric lung diseases; acute lung injury and
critical care medicine; and interstitial lung diseases and lung immunology
including pulmonary fibrosis, sarcoidosis, and pulmonary manifestations of
human immunodeficiency virus (HIV)/AIDS and associated infections, with
emphasis on active and latent TB and drug-resistant TB. Basic research focuses
on lung development and cell biology, including stem cell biology and
cell-based therapies, and mechanisms of disease etiology and pathogenesis.
Clinical studies focus on evaluating innovative therapies for acute lung injury
and acute respiratory distress syndrome (ARDS), pulmonary fibrosis, neonatal
lung disease, pulmonary embolism, and pulmonary hypertension.
National Center on Sleep Disorders Research
The National Center on Sleep Disorders Research
(NCSDR) plans, directs, and supports basic, clinical, and applied research,
health education, and training in sleep and sleep disorders. It oversees
developments in its program areas; assesses the national needs for research on
causes, diagnosis, treatment, and prevention of sleep disorders and sleepiness;
and coordinates sleep research activities across several Federal Government
Agencies and with professional, voluntary, and private organizations. The
Center promotes information sharing and coordinates implementation of
inter-Agency programs.
The NHLBI sleep research program seeks to understand
the molecular, genetic, and physiological regulation of sleep and the
relationship of sleep disorders to CVD. It also supports efforts to understand
the relationships of sleep restriction and sleep-disordered breathing to the
metabolic syndrome, including obesity, high blood pressure and stroke,
dyslipidemia, insulin resistance, and vascular inflammation. Ongoing
NHLBI-funded research projects include elucidating the etiology and
pathogenesis of sleep disorders, particularly sleep apnea; determining the role
of sleep apnea in CVD and cerebrovascular disease; examining sleep and sleep
disorders across the lifespan; and identifying new animal models of sleep
disorders.
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Division of Blood Diseases and
Resources
The DBDR plans and directs research and research
training on the causes, treatment, and prevention of blood diseases and
disorders. Areas of interest encompass a broad spectrum of research, from stem
cell biology to medical management of blood diseases, with a focus on
nonmalignant and premalignant processes. The Division has a leading role in
developing cell-based therapies, combining the expertise of transfusion
medicine and stem cell technology with the exploration of repair and
regeneration of human tissues and biological systems. SCCORs and other
specialized centers support collaborative clinical research in hemostatic and
thrombotic diseases, transfusion biology and medicine, SCD, and cell-based
therapy for blood diseases. Clinical networks support collaborative clinical
research in rare diseases, bone marrow transplantation, and transfusion
medicine/hemostasis. The DBDR also has a major responsibility to improve the
adequacy and safety of the Nations blood supply.
The Division is organized into the three major
branches described below.
Blood Diseases Branch
The Blood Diseases Branch supports research and
research training in nonmalignant disorders of the hematopoietic system,
including SCD and thalassemia. Attention is focused on reducing morbidity and
mortality caused by the disorders and preventing their occurrence.
Research in SCD and thalassemia ranges from
elucidating their etiology and pathophysiology to improving disease treatment
and management. Areas of emphasis include genetics, regulation of hemoglobin
synthesis, iron chelation, development of drugs to increase fetal hemoglobin
production, and gene therapy. Developing animal models for preclinical studies
is another area of interest. Clinical studies in SCD are investigating stroke
prevention and the long-term effects of hydroxyurea therapy. A Phase III
clinical trial is determining whether hydroxyurea is effective in preventing
chronic end-organ damage in children with SCD.
The Branch oversees a program of Comprehensive Sickle
Cell Centers. The Centers conduct basic and collaborative clinical research and
provide state-of-the-art patient care, educational activities for patients and
health professionals, community outreach, and genetic counseling services.
Clinical networks in thalassemia and SCD are
evaluating new treatment strategies and ensuring that research findings on
optimal management of the disease are rapidly disseminated to practitioners and
health care professionals.
Thrombosis and Hemostasis Branch
The Thrombosis and Hemostasis Branch supports research
and research training in hemostasis, thrombosis, and endothelial cell biology.
It oversees a comprehensive program of basic research, clinical studies, and
technology development that focuses on understanding the pathogenesis of
arterial and venous thrombosis to improve the diagnosis, prevention, and
treatment of thrombosis in heart attack, stroke, and peripheral vascular
diseases. A major goal is to find additional platelet inhibitors,
anticoagulants, and fibrinolytic agents that will improve specificity and
reduce side effects when used in treatment of thrombotic and thromboembolic
disorders.
The Branch also supports research on bleeding
disorders (e.g., hemophilia and von Willebrand disease) and immune disorders
(e.g., idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic
purpura, and systemic lupus erythematosus). Emerging areas of interest are gene
transfer; clinical proteomics; inflammation and thrombosis; stroke; coagulation
activation; autoimmune disease; and thrombotic complications of obesity,
diabetes, and cancer.
Transfusion Medicine and Cellular Therapeutics
Branch
The Transfusion Medicine and Cellular Therapeutics
Branch plans and directs research and research training in transfusion
medicine, stem cell biology and disease, and clinical cellular medicine. It
supports research on the use, safety, and availability of blood and blood
components for transfusion and cellular therapies. Research areas include
transmission of disease, noninfectious complications of transfusions,
immunobiology, cell biology and disease, cell-based therapies, hematopoietic
stem cell transplantation, and overall product availability.
The Branch develops programs for basic and clinical
research related to normal and abnormal cellular biology and pathology. It also
collaborates with governmental, private sector, and international organizations
to improve the safety and availability of the global supply of blood and blood
components.
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Division of Prevention and
Population Sciences
The DPPS supports and provides leadership for
population- and clinic-based research on the causes, prevention, and clinical
care of cardiovascular, lung, and blood diseases and sleep disorders. Research
includes a broad array of epidemiological studies to describe disease and risk
factor patterns in populations and to identify risk factors for disease;
clinical trials of interventions to prevent disease; studies of genetic,
behavioral, sociocultural, and environmental influences on disease risk and
outcomes; and studies of the application of prevention and treatment strategies
to determine how to improve clinical care and public health. The Division also
supports training and career development for these areas of research.
The Division is organized into the three major
branches described below.
Clinical Applications and Prevention Branch
The Clinical Applications and Prevention Branch
supports, designs, and conducts research and supports training on behavioral,
environmental, clinical, and health care approaches to reduce occurrence and
consequences of CVD. Prevention research examines effects of interventions to
slow or halt risk factors or disease development or progression. Interventions
use high-risk individual and population approaches, including medications,
behavioral strategies, and environmental change. Studies examine lifestyle,
nutrition and exercise, psychological and sociocultural factors, and
environmental and genetic influences relevant to prevention. Clinical
application research examines approaches to improve health care delivery and
patient outcomes. Studies include clinical and community trials and selected
observational studies.
Epidemiology Branch
The Epidemiology Branch supports, designs, and
conducts research and supports training in the epidemiology of cardiovascular,
lung, and blood diseases and sleep disorders. Studies are conducted to identify
temporal trends and population patterns in the prevalence, incidence,
morbidity, and mortality from the diseases and include single- and multicenter
observational epidemiology studies of development, progression, and treatment
of cardiovascular, lung, and blood diseases and sleep disorders. Studies
identify environmental, lifestyle, physiological, and genetic risk factors for
disease and risk factor development including characterization of
genegene and geneenvironment interactions. The Branch also
distributes data from all eligible NHLBI studies to researchers as a national
data resource and adheres to guidelines that protect participant privacy and
confidentiality.
Womens Health Initiative Branch
The Womens Health Initiative Branch supports
clinical trials and observational studies to improve the understanding of the
causes and prevention of major diseases affecting the health of women. Current
studies focus on CVD, cancer, and fractures, in collaboration with National
Cancer Institute (NCI), National Institute of Arthritis and Musculoskeletal and
Skin Diseases (NIAMS), National Institute of Aging (NIA), National Institute of
Neurological Disorders and Stroke (NINDS), and Office of Research on
Womens Health (ORWH). Large multicenter observational epidemiology
studies seek to identify risk markers for disease or better quantify known
markers by using data from questionnaires, clinical examinations, and
laboratory analyses. The long-term clinical trials test promising but unproven
interventionssuch as hormone therapy, diet, and supplements to prevent
major diseasesand evaluate overall effects on health. The Branch has
established an infrastructure to support the use of data and blood samples from
the studies by the scientific community.
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Division of Intramural
Research
The DIR conducts laboratory and clinical research in
heart, vascular, lung, blood, and kidney diseases and develops technology
related to cardiovascular and pulmonary diseases. Areas of interest include the
biology of experimental and clinical arteriosclerosis and its manifestations;
pathophysiology of hypertensive vascular disease; functions of the lung;
clinical and experimental studies on physiologic and pharmacologic aspects of
heart, lung, and blood diseases; and a broad program of other basic research
and technical developments related to them.
The DIR includes the following four centers and three
branches:
Biochemistry and Biophysics Center
The Biochemistry and Biophysics Center develops a
global view of the molecular basis of structurefunction relationships of
proteins and biologically relevant molecules. It performs state-of-the-art
nuclear magnetic resonance (NMR) spectroscopy studies of protein structure and
functional interactions, develops mathematical tools for generating theoretical
models of protein structurefunction relationships, elucidates the
mechanisms of enzyme function, and investigates the relationship between
protein structurefunction and cell signaling pathways.
Cell Biology and Physiology Center
The Cell Biology and Physiology Center develops a
global view of the mechanisms that regulate cellular function and physiology.
It evaluates the mechanisms that control different molecular machines within
the cytosol, including those involved in muscle contraction and cytosolic and
membrane transport processes. The Center studies cellular signaling events
associated with hormone action, cytosolic trafficking, and energy metabolism;
investigates the role of cellular processes on function and adaptation in
whole-animal model systems; and develops unique measuring devices for studying
biochemical and physiological processes in intact cells, whole animals, and
clinical situations.
Genetics and Development Biology Center
The Genetics and Development Biology Center develops a
global view of the mechanisms that regulate cardiovascular development and the
etiology of congenital heart anomalies and CVD. It evaluates the function of
specific genes and transcription factors in the development of the heart and
other tissues, develops techniques and approaches for gene delivery and gene
therapy in model systems, and works toward a better understanding of basic
processes involved in regulating and interpreting the genetic code in
development and disease.
Immunology Center
The Immunology Center develops a global view of the
molecular basis of immune processes. It studies the intracellular and signaling
processes involved in the activation of lymphocytes and mast cells,
investigates the mechanisms by which drugs and other agents result in
allergicautoimmune reactions, and relates the results to the development
of new diagnostic and therapeutic approaches in humans.
Translational Medicine Branch
The Translational Medicine Branch conducts biomedical
research directed at defining at the molecular level, normal and abnormal
biologic function. It develops diagnostic and therapeutic modalities for the
treatment and understanding of CVD and implements mechanism-based clinical
studies centered on innovative discoveries and observations from inside and
outside of the Branch.
Hematology Branch
The Hematology Branch conducts basic and clinical
research on normal and abnormal hematopoiesis. Areas of interest include bone
marrow failure, viral infections of hematopoietic cells, gene therapy of
hematologic and malignant diseases, bone marrow transplantation, and mechanisms
of immunologically mediated syndromes such as graft-versus-host disease and
autoimmune diseases.
Pulmonary and Vascular Medicine Branch
The Pulmonary and Vascular Medicine Branch conducts
research on the lung, heart, and systemic vasculature directed at
definingat the molecular, biochemical, and functional levelsnormal
physiological function and novel mechanisms of disease. It conducts research in
emerging diseases of the lung characterized by unknown etiology and molecular
pathogenesis. Areas of interest include lung diseases in blacks such as sickle
cell lung disease and sarcoidosis; the role of nitric oxide, nitrite, gender,
preconditioning and mitochondrial function on the modulation of ischemia and
reperfusion injury of the heart and lung; and translational study and drug
development for therapeutic modulation of vascular, pulmonary, and cardiac
cellular and molecular dysfunction in diseases of the lung and heart.
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Division for the Application of
Research Discoveries
The DARD coordinates the translation and dissemination
of research findings and scientific consensus to health professionals,
patients, and the public, so that information can be adapted for, and
integrated into, health care practice and individual health behavior. Special
attention is given to eliminate health disparities among high-risk, low-income,
and minority populations.
The Division is organized into the three branches
described below.
Research Translation Branch
The Research Translation Branch fosters the rapid
translation of emergent knowledge into practice by synthesizing and organizing
evidence around priority diseases and conditions and identifies knowledge gaps
that need to be addressed by future research. It promotes the use of
evidence-based reviews and develops or facilitates the development of clinical
guidelines with relevant stakeholders. Additionally, it develops support for
clinical decisions and other innovative implementation applications for use in
clinical and public health practice settings. Through the use of knowledge
networks and other strategies, it enables researchers and users of research to
discuss issues of research applicability, relevance, and utility that may offer
guidance to future research needs and opportunities.
Enhanced Dissemination and Utilization Branch
The Enhanced Dissemination and Utilization Branch
collects, synthesizes, and communicates new knowledge and recommendations for
dissemination and utilization of research-based findings to diverse target
audiences, including minority and underserved groups. It provides technical
assistance and information resources to enhance NHLBI grantees
dissemination plans and practices and accelerates the speed with which
evidence-based tools and education programs move into community practice
settings. Additionally, it establishes community-based Enhanced Dissemination
and Utilization Centers committed to applying and evaluating the impact of the
latest research advanced in multiple settings to achieve the U.S. Department of
Health and Human Services (HHS) Healthy People goals and to eliminate health
disparities. The Branch evaluates the effectiveness of its dissemination and
utilization activities so that it can apply lessons learned to future
programs.
Health Communications and Social Marketing
Branch
The Health Communications and Social Marketing Branch
supports communication of health information to health care professionals,
patients, and the public. Using results of the latest communications and social
marketing research, the Branch plans health communications strategies and
develops consumer messages and public education campaigns. It develops and
maintains media relations and communicates research and educational messages
through multiple media channels. In addition, the Branch operates the NHLBI
Health Information Center to respond to professional and public inquiries and
to develop and market publications and online information to health care
providers and the public. The Center also manages NHLBI exhibit programs.
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