Barrasa A, rez-Hoyos S, Santos I, Romero JD, Soriano V, Amo JD; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. WePeC6058.
Centro Nacional de Epidemiologia, Madrid, Spain
BACKGROUND: HCV has been suggested as a co-factor for HIV disease progression. The objective of this paper is to study how HCV co-infection affects HIV progression in a cohort of persons with well-documented dates of seroconversion followed for 15 years. METHOD: Cohort study of HIV seroconverters recruited from 1985 onwards in Madrid. Diagnoses of HCV infection were established through a positive HCV antibody test. Cox proportional Hazards models were used to study the association between HCV co-infection and HIV progression in persons infected for the same length of time adjusting for potential confounders. RESULTS: From January 1985 to May 2000, 226 seroconverters were identified. 181 had HCV serology available of whom 84% were male, 64% homo/bisexual and 23% injected drugs users (IDU). 15,4% developed AIDS; pulmonary tuberculosis and Kaposi Sarcoma were the commonest conditions. Forty-seven (26%) were HCV-positive of whom 74,5% were male, 78,7% were IDU and 25,5% had developed AIDS. Being co-infected with HCV was not associated with faster progression to AIDS nor death in neither univariate (HR 1.43 95%CI:0.64-3.22 and HR 2.0 95%CI:0.52-7.68 respectively) nor multivariate analysis (HR 0.68 95%CI:0.27-1.74 and HR 0.78 95%CI:0.07-9.17 respectively). CONCLUSIONS: The majority of patients co-infected by HIV and HCV are male and IVDU. Being HCV co-infected is not associated with faster progression to AIDS when comparing persons infected by HIV for the same length of time.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Bisexuality
- Cohort Studies
- Disease Progression
- HIV
- HIV Infections
- HIV Seropositivity
- Hepacivirus
- Humans
- Male
- Proportional Hazards Models
- Spain
Other ID:
UI: 102252465
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