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sevoflurane A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name: | | Ultane | | | Chemical structure names: | | - 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
- Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-
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