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anti-CD19/anti-CD3 recombinant bispecific monoclonal antibody MT103 A recombinant, single-chain, anti-CD19/anti-CD3 bispecific monoclonal antibody with potential immunostimulating and antineoplastic activities. Anti-CD19/anti-CD3 recombinant bispecific monoclonal antibody MT103 posesses two antigen-recognition sites, one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR), and one for CD19, a tumor-associated antigen (TAA) overexpressed on the surface of B cells. This bispecific monoclonal antibody brings CD19-expressing tumor B-cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CD19-expressing B-lymphocytes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081024152536im_/http://www.cancer.gov/images/spacer.gif) | bispecific T-cell engager MT103 | | ![](https://webarchive.library.unt.edu/eot2008/20081024152536im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081024152536im_/http://www.cancer.gov/images/spacer.gif) | MEDI-538 MT-103 | | ![](https://webarchive.library.unt.edu/eot2008/20081024152536im_/http://www.cancer.gov/images/spacer.gif) |
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