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flutamide A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Flucinom Flugerel Niftolid | | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Eulexin | | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Apimid Chimax Drogenil Euflex Eulexine Flucinome Fluken Flulem Flutabene Flutacan Fluta-Gry Flutamex Flutamin Flutan Flutaplex Fugerel Grisetin Oncosal Profamid Prostacur Prostadirex Prostica Prostogenat Tafenil Tecnoflut Testotard | | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | FLUT | | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Sch 13521 | | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20081025050042im_/http://www.cancer.gov/images/spacer.gif) | - 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- 4'-nitro-3'-trifluoromethylisobutyranilide
- alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide
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