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HuC242-DM4 An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated with a derivative of cytotoxic agent maytansine, DM4, with potential antitumor activity. huC242-DM4 is generated based on MoAb C242, which is raised against a cell surface superantigen, CA242, found in a variety of human tumor cells. Upon binding and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result, this agent prevents cell division and reduces cell growth of cancer cells that express CA242. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081025080934im_/http://www.cancer.gov/images/spacer.gif) | maytansinoid DM4-conjugated humanized monoclonal antibody huC242 | | ![](https://webarchive.library.unt.edu/eot2008/20081025080934im_/http://www.cancer.gov/images/spacer.gif) |
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