Protopic| (Other name for: tacrolimus) |
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Provecta
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Provenge| (Other name for: sipuleucel-T) |
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Proventil| (Other name for: albuterol sulfate) |
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Provera Dosepak| (Other name for: medroxyprogesterone) |
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Provigan| (Other name for: promethazine hydrochloride) |
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Provigil| (Other name for: modafinil) |
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PRX302| A targeted prodrug consisting of a recombinant modified form of the Aeromonas protoxin proaerolysin (PA), bearing a prostate-specific protease cleavage site, with potential antineoplastic activity. When injected directly into the prostate, PRX302 is hydrolyzed to the active toxin aerolysin by the serine protease prostate specific antigen (PSA), a protein overexpressed by prostate cancers and prostate cells in hyperplastic prostatic tissue. Aaerolysin molecules then oligomerize to form ring-like heptamers that are incorporated into the lipid bilayers of cell membranes, forming large membrane channels and resulting in the leakage of cellular contents and lysis of PSA-expressing prostate cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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PSA:154-163(155L) peptide vaccine| A cancer vaccine comprised of a synthetic peptide with an amino acid sequence corresponding to positions 154-163 of the amino acid sequence for prostate-specific antigen (PSA) with a leucine substitution at position 155. Upon administration, PSA:154-163(155L) peptide vaccine may elicit a cytotoxic T-cell response against tumor cells that express PSA. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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psilocybin| A tryptamine alkaloid, isolated from various genera of fungi including the genus Psilocybe, with hallucinogenic, anxiolytic, and psychoactive activities. In vivo, psilocybin is rapidly dephosphorylated into the active compound psilocin, which activates serotonin 2A (5-HT2A) receptors in the central nervous system (CNS), mimicking the effects of serotonin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Pulmozyme| (Other name for: dornase alfa inhalation solution) |
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Purinethol| (Other name for: mercaptopurine) |
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Purlytin| (Other name for: tin ethyl etiopurpurin) |
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PV-10| An injectable ten percent solution of rose bengal disodium, an iodinated fluorescein derivative, with potential antineoplastic and radiosensitizing activities. When injected into tumor tissue, PV-10 specifically targets and concentrates in tumor cells, producing cytotoxic singlet oxygen when exposed to ionizing radiation. In addition, PV-10 may stimulate an anti-tumor immune response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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PV701| An attenuated, replication-competent, oncolytic strain of Newcastle disease virus. PV701 selectively lyses tumor cells. The selectivity of this agent is related to defects in the interferon-mediated antiviral response found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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PVA microporous hydrospheres| An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers. These water-soluble, compressible microspheres may be used to encapsulate various therapeutic agents; drug-loaded microspheres can then be used as a drug delivery vehicle during embolization of tumor vasculature.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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PVA microporous hydrospheres/doxorubicin hydrochloride| An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyrazine diazohydroxide
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pyrazofurin| A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyrazoloacridine| A 9-methoxy acridine compound containing a reducible 5-nitro substituent. Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyridoxine hydrochloride| The hydrochloride salt of pyridoxine, a water-soluble B vitamin. Pyridoxine is converted in the liver into the metabolically active coenzyme form pyridoxal 5'-phosphate (P5P), an essential cofactor in many enzymatic reactions in amino acid metabolism, including transamination, deamination, and decarboxylation. P5P is required for glycogenolysis and the synthesis of sphingolipids and is essential to red blood cell, nervous system, and immune system functions. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyrimethamine| A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyroxamide| A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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pyruvate kinase inhibitor TLN-232| A synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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