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Polo-like kinase 1 inhibitor GSK-461364
A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Abbreviation: | | PLK-1 inhibitor GSK-461364 | | | | Code name: | | GSK-461364 | | |
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