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estramustine phosphate sodium
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | estramustine Phosphate | | | | US brand name: | | Emcyt | | | | Foreign brand name: | | Estracyt | | | | Abbreviation: | | EM | | | | Code names: | | Leo-299
Ro 22-2296/000 | | | | Chemical structure names: | | - estra-1,3,5(10)-triene-3,17-diol(17(beta))-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate
- estramustine 17-(dihydrogenphosphate) disodium salt
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