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quinine A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081025035858im_/http://www.cancer.gov/images/spacer.gif) | QUIN | | ![](https://webarchive.library.unt.edu/eot2008/20081025035858im_/http://www.cancer.gov/images/spacer.gif) |
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Previous: | quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, quarfloxacin, quinacrine dihydrochloride, Quinamed, quinidine | Next: | Quixin, Qvar, R(+)XK469, R-flurbiprofen, racemic XK469 |
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