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denileukin diftitox
A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | DAB(389)-interleukin-2
DAB389 interleukin-2
DAB389 interleukin-2 immunotoxin | | | | US brand name: | | ONTAK | | | | Abbreviation: | | DAB389-IL2 | | | | Code name: | | LY335348 | | |
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