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melphalan
An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | alanine nitrogen mustard
L-phenylalanine mustard
L-Sarcolysin
L-Sarcolysin Phenylalanine mustard
L-Sarcolysine
Phenylalanine Mustard
Phenylalanine Nitrogen Mustard
Sarcoclorin | | | | US brand name: | | Alkeran | | | | Foreign brand names: | | Alkerana
Melfalan
Melphalanum
Sarkolysin | | | | Abbreviation: | | L-PAM | | | | Code names: | | CB-3025
WR-19813 | | | | Chemical structure names: | | - 4-[bis(2-chloroethyl)amino]-L-phenylalanine
- p-di(chloroethyl)amino-L-phenylalanine
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