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humanized monoclonal antibody MEDI-522
A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Humanized monoclonal antibody MEDI-522 blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | monoclonal antibody anti-alpha V beta 3 integrin MEDI-522 | | | | US brand name: | | Abegrin | | | | Code name: | | MEDI-522 | | |
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