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RFT5-dgA immunotoxin
A recombinant immunotoxin consisting of the monoclonal antibody RFT5 fused to deglycosylated ricin A-chain with potential antitumor activity. The RFT5-dgA immunotoxin selectively targets the interleukin 2 receptor (IL-2R), a cell surface antigen expressed on activated normal T and B cells and macrophages and frequently upregulated on the cell surface of many hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, thereby facilitating the entry of the immunotoxin and killing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Abbreviation: | | IgG-RFT5-dgA | | |
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