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recombinant tissue plasminogen activator
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, recombinant tPA increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | t-PA | | | | US brand name: | | Activase | | | | Abbreviation: | | rt-PA | | |
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