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trabectedin
A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin inteferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks.and blocks the cell cycle in the G2 phase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | Ecteinascidin | | | | Foreign brand name: | | Yondelis | | | | Abbreviation: | | ET 743 | | |
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