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trimethoprim-sulfamethoxazole
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | cotrimoxazole
Eslectin
insozalin
trimedin
trimezole | | | | US brand names: | | Bactrim
Cotrim
Septra
Sulfamethoprim
Sulfatrim
Sulmeprim | | | | Abbreviations: | | SMZ-TMP
TMP-SMX | | |
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