Previous Section | Table of Contents | Next Section
FISCAL YEAR 1994
Principle Investigator -
Norcross
"Cryptic nature of envelope V3 Region
epitopes protects primary monocytotropic
Human Immunodeficiency Virus Type
1 from Antibody Neutralization."
Dumith Chequer Bou-Habib, et al.
Journal of Virology, Sept.,
1994; 68 (3).
Principle Investigator -
Norcross
"Mediation of human immunodeficiency
virus type 1 binding by interaction
of cell surface heparan sulfate proteoglycans
with the V3 region of envelope gp120-gp41."
Roderigues, et at. Journal of
Virology, Apr 1995; 69 (4): 2233-2239
Principle Investigator -
Sheehan
"ICI 182,780 inhibits endogenous
estrogen-dependent rat uterine growth
and Tamoxifen-induced developmental
toxicity." William S. Branham, et
al. Biology of Reproduction,
1995; 54: 160-167
Principle Investigator -
Sheehan
"Effects of Tormifene on neonatal
rate uterine growth and differentiation."
Kevin L. Medlock, et al. Biology
of Reproduction, 1997;56.
Principle Investigator -
Fein
"Risk of diarrhea related to iron
content of infant formula: lack of
evidence to support the use of low-iron
formula as a supplement for breastfed
infants." Paula D. Scariati, et al
Pediatrics, March, 1997; 99
(3).
Prinicipal Investigator -
Trapnell
"Quantitation of vaginal administered
Nonoxynol-9 in premenopausal women."
Patricia Barditch-Corvo, et al. Contraception,
1997;55.
Principle Investigator -
Woosley
"Sex hormone prolong the QT Interval
and downregulate potassium channel
expression in the rabbit heart."
Milou D. Drici, et al. Circulation,
Sept., 15, 1996; 94 (6).
FISCAL YEAR 1995
Principal Investigator -
James
"Characterization of cellular response
to silicone implants in rats: implications
for foreign-body carcinogenesis."
S. Jill James, et al. Biomaterials,
1997; 18 (9).
Principal Investigator -
Finbloom
"Impaired interferon-a-induced signaling
in peripheral blood mononuclear cells
from patients with SLE and RA." J.
of Immunology , 1997
Principle Investigator -
Trapnell
"Thalidomide does not affect the
pharmacokinetics of ethynil estradiol
and norethindrone." C. Trapnell,
et al. Clin Pharmacol Ther,
Dec 1998, 64 (6): 597-602.
Principle Investigator -
Wear
"Assessment of bone density using
ultrasonic backscater." Wear and
Garra. Ultrasound in Med &
Biol, 24 (5): 689-95, 1998.
FISCAL YEAR 1996
Principle Investigator -
Beland
"Identification of Tamoxifen-DNA
adducts formed by 4-Hydroxytamoxiden
Quinone Methide." M. Matilde Marques
and Frederick A. Beland. Carcinogenesis,
1997; 18 (10).
Principle Investigator -
Tosato
"Mig, the monokine induced by interferon-a.
Promotes Tumor Necrosis in vivo."
Cecilia Sgadari, et al. Blood.
April 15, 1997; 89 (8)/
Principle Investigator -
Tosato
"Interferon-inducible protein-10
identified as a mediator of tumor
necrosis in vivo." Cecilia Sgadari,
et al. Proc. Natl. Acad. Sci,
Nov. 1996; 93.
Principle Investigator -
Volpe
"Comparative in vitro toxicology
of alkylating agents to normal human
myeloid progenitor cells." Volpe
et al. J of Soc. for in-vitro
Biol. 34 (9): Oct 1998
Principle Investigator -
Sheehan
"Quantitative structure-activity
relationships (QSARs) for estrogen
binding to the estrogen receptor:
predications across species." Tong
W, Perkins R, Strelitz R, Collantes
ER, Keenan S, Welsh WJ, Branham WS,
Sheehan Dm. Environ. Health Prospect
105:1116-24; 1998.
Principle Investigator -
Sheehan
"QSAR models for binding of estrogenic
compounds to estrogen receptor alpha
and beta subtypes." Tong W, Perkins,
Xing L, Welsh WJ, Sheehan Dm. Endocrine.
138:4022-5; 1997.
Principle Investigator -
Sheehan
"Evaluation of quantitative structure-activity
relationship methods for large-scale
prediction of chemicals binding to
the estrogen receptor." Tong W, Lowis
DR, Perkins R, Chen Y, Welsh WJ,
Goddette DW, Heritage TW, Sheehan
DM. J. Chem. Inf. Comput. Sci.
38:669-77; 1998.
Principle Investigator -
Sheehan
"Estrogen receptor relative binding
affinities of 188 natural and xenochemicals:
structural diversity of ligands."
Blair R, Fang H, Branham WS, Hass
B, Dial SL, Moland CL, Tong W, Shi
L, Perkins R, Sheehan DM. Toxiol.
Sci. 54:138-153; 2000.
Principle Investigator -
Sheehan
"Comparison of estrogen receptor
alpha and beta subtypes based on
comparative molecular field analysis
(CoMFSA)." Xing L, Welsh WJ, Tong
W, Perkins R, Sheehan Dm SAR/QSAR
Environ. Res. 10:215-237;
1999.
Principle Investigator -
Sheehan
"Perspectives in three-dimensional
quantitative structure-activity relationship
(3D-QSAR)/comparative molecular field
analysis (CoMFA) in determining estrogenic
effects." Tong W, Perkins R, Sheehan
DM. Japan Chemistry Today
2:50-57: 1999.
Principle Investigator -
Sheehan
"Phytoestrogens and synthetic chemicals
as developmental endocrine disruptors."
Sheehan DM, Branham WS, Tong W, Perkins
R. Newsletter Japan 2:3; 1998.
Principle Investigator -
Sheehan
"Quantitative comparison of in vitro
assays for estrogenic activity."
Fang H, Tong W, Perkins R, Soro A,
Prechtl N, Sheehan DM. Environ.
Health Perspect.; 2000 (in press).
Principle Investigator -
Klinman
"DNase treatment does not improve
the survival of lupus prone (NZB
x NZW)F1 mice." D. Verthelyi, et
al. Lupus. 1998; 7(4) 223-30.
FISCAL YEAR 1997
Principle Investigator -
H. Golding
"Expression and function of CCR5
and CXCR4 on human Langerhans cells
and macrophages: Implications for
HIV primary infection." M. Zaitseva
et al. Nature Medicine. 3
(12), Dec 1997
Principle Investigator -
H. Golding
" CXCR4 and CCR5 on human thymocytes:
biological function and role in HIV-1
infection." M. Zaitseva et al. J
of Immunology. 161: 3101-3113,
1998
Principle Investigator -
H. Golding
"Cutting Edge: Cytokines regulate
expression and function of the HIV
coreceptor CXCR4 on human mature
dendritic cells." JP Zoeteweij et
al. J of Immunology. 161:
3219-3223, 1998
Principle Investigator -
H. Golding
"Fusion of monocytes and macrophages
with HIV-1 correlates with biochemical
properties of CXCR4 and CCR5." C.Laham
et at. Nature Medicine. 5
(3), March 99
Principle Investigator -
James
"Abnormal folate metabolism and mutation
in the methylenetetrahydrofolate
reductase gene may be maternal risk
factor for Down syndrome." SJ James
et al. Am J Clin Nutr, 70:
1-8; 1999
Principle Investigator -
James
"A new HPLC method for the simultaneous
determination of oxidized and reduced
plasma aminothiols using coulometric
elctrochemical detection. S Melnyk
et al. J of Nutr Biochem.
10: 490-97; 1999
Principle Investigator -
James
"Measurement of plasma and intracellular
S-adenosylmethionine and S-adenosylhomocysteine
utilizing coulometric electrochemical
detection: alterations with plasma
homocysteine and pyridoxal 5'phosphate
concentrations." S Melnyk et al.
Clin Chem, 46:2; 265-272;
2000
Principle Investigator -
James
"Increase in plasma homocysteine
associated with parallel increases
in plasma S-adenosylhomocysteine
and lymphocyte DNA hypomethylation."
P Yi, et al., J Bio Chem,
May 2000
Principle Investigator -
Szarfman
"A Baysian screening criterion for
ranking cell counts in frequency
tables derived from large databases,
with an application to FDA Spontaneous
Reporting system." DuMouchel, et
al. The American Statistician,
. Aug 1999
FISCAL YEAR 1998
Principle Investigator -
Wear
"Frequency dependence of ultrasonic
backscatter from human trabecular
bone: theory and experiment", K.
A. Wear, J. Acoust. Soc. Am,
vol. 106, no. 6, 3659-3664, Dec.,
1999
Principle Investigator -
Wear
"The effects of frequency-dependent
attenuation and dispersion on sound
speed measurements: applications
in human trabecular bone". K. A.
Wear, IEEE Trans Ultrason. Ferro.
Freq. Cont., 47, 265-273, January,
2000.
Principle Investigator -
Wear
"Measurements of phase velocity and
group velocity in human calcaneus",
K. A. Wear, Ultrasound Med. Biol.
2000 May 1; 26(4): 641-646, vol.
26, no. 3, 469-472, 2000.
Principle Investigator -
Wear
"Temperature dependence of ultrasonic
attenuation in human calcaneus",
K. A. Wear, Ultrasound Med. Biol.,
vol. 26, no. 3, 469-472, 2000.
Principle Investigator -
Wear
"Anisotropy of ultrasonic backscatter
and attenuation from human calcaneus:
implications for relative roles of
absorption and scattering in determining
attenuation", K. A. Wear, J. Acoust.
Soc. Am., 107(6), June, 2000.
Principle Investigator -
Wear
"A model for ultrasonic backscatter
from trabecular bone," KA Wear, Proc.
IEEE Symp. Ultrason., Lake
Tahoe, CA, Oct. 17-21, 1999.
Principle Investigator -
Wear
KA Wear, "Variations in transit-time-based
ultrasonic velocity estimates in
human calcaneus due to frequency-dependent
attenuation and dispersion," Proc.
SPIE Medical Imaging 2000 Conf,
San Diego, CA, Feb. 12-17, 2000.
FISCAL YEAR 1994
Principle Investigator -
Miller
"Restricted and shared patterns of
T-cell receptor VB-chain gene expression
in silicone breast implant capsules
and other inflammatory tissues from
patients with connective tissue disease."
O'Hanlon et al.
Principle Investigator -
Miller
"Laser-Raman microprobe identification
of inclusions in capsules associated
with silicone gel breast implants."
J. Centero et al.
Principle Investigator -
Miller
"Silicone gel-filled breast and testicular
implant capsules: a histologic and
immunophenotypic study." S. Abbondanzo
et al. Submitted to Modern Pathology
FISCAL YEAR 1995
Principle Investigator -
Klinman
"Effects of sex hormones on the activity
of cytokine-secreting cells in pre-
and post-menopausal women." Submitted
to J of Immunology.
Principle Investigator -
Ediger
"Raman spectroscopy and silicone
quantification." Submitted to Applied
Spectroscopy.
Principle Investigator -
B. Golding
"Mucosal immunity in mice immunized
with HIV-1 peptides conjugated to
Brucella abortus." Submitted to AIDS
Research and Human Retrovirus.
FISCAL YEAR 1996
Principle Investigator -
M. Myers
"The cause of cessation of viral
passage through holes in latex condoms."
R. Menta, et al. Submitted to J
of Natural Rubber Research.
Principle Investigator -
Shacter
"Gender differences in the response
to acute myocardial infarction: implications
of earlier death for men." Wright,
et al. Submitted to NEJM.
Principle Investigator -
Sheehan
"An Intergrated "Four-Phase" approach
priority setting of endocrine disruptors
- Part 2: Phase III QSAR models using
a large diverse set of estrogens."
Shi LM, Fang H, Tong W, Wu J, Perkins
R, Blair R, Branham W, Sheehan D.
Sunbmitted to Journal Chemical
Information and Computer Sciences:
2000.
Principle Investigator -
Sheehan
"An integrated "four-phase" approach
for priotity setting of endocrine
disruptors - Part 1: Phase I and
II for prediction of potential estrogenic
endocrine disruptor." Shi LM, Tong
W, Fang H, Perkins R, Wu J, Tu M,
Blair R, Branham W, Waller C, Sheehan
D. Submitted to Environ. Health
Perspect.; 2000.
Principle Investigator -
Brown
Silicone gel breast implant rupture
prevalence in a population of women
in Birmingham, Alabama. Brown SL,
Middleton MS, Berg WA, Soo MS, Pennello
G. American Journal of Roentgenology,
in press.
Principle Investigator -
Brown
Silicone gel breast implant rupture,
extracapsular silicone, and health
status in a population of women.
Brown SL, Pennello G, Berg WA, Soo
MS, Middleton MS. Submitted to J
Rheumatology.
Principle Investigator -
Brown
Replacement surgery and silicone
gel breast implant rupture: Self-report
by women after mammoplasty. Brown
SL, Pennello G. Submitted to Epidemiology.
FISCAL YEAR 1997
Principle Investigator -
Marinac-Dabic
"Impact of gender on the acute and
long-term (1 year) outcome following
stneting with the Palmaz-Schatz Stent."
Marinac-Dabic, et al. Submitted to
Am Heart Journal.
Principle Investigator -
James
"Measurement of plasma and intracellular
s-adenosylmethinine and s-adenosylhomocysteine
using coulometric electrochemical
detections: changes with plasma honocysteine
and B6 levels." S. Melnyk, et al.
Submitted to Clin Chemistry.
Principle Investigator -
James
"Plymorphisms in genes involved in
folate metabolism as maternal risk
factors for Down syndrome." C Hobbs,
et al., Submitted to Am J Hum
Genetics.
FISCAL YEAR 1998
Principle Investigator -
Wear
"The relationship between ultrasonic
backscatter and bone mineral density
in human calcaneus," K. A. Wear and
D. W. Armstrong, Accepted for publication
in IEEE Trans Ultrason. Ferro.
Freq. Cont.
Principle Investigator -
Wear
"Relationship of ultrasonic backscatter
with ultrasonic attenuation, sound
speed, and bone mineral density in
human calcaneus", K. A. Wear, and
J. Reynolds, Accepted for publication
in Ultrasound in Medicine and
Biology,- conditioned on adequate
response to reviewers' suggestions.
Principle Investigator -
Wear
"Ultrasonic attenuation in human
calcaneus from 0.2 to 1.7 MHz", K.
A. Wear, Submitted to IEEE Transactions
on Ultrasonics, Ferroelectrics, and
Frequency Control.
Principle Investigator -
Wear
"Computer Simulation and Experiments
to Investigate Sound-Speed Estimates
in Cancellous Bone," K. A. Wear,
Submitted to Comp. Sim. Model.
Med..
FISCAL YEAR 1994
Principal Investigator -
Merkatz
FDA Regulated Products and Pregnant
Women- Conference and Executive Summary,
1995
Principal Investigator -
Sierka
MQSA Speakers kit, consumer brochure
and logo
Principal Investigator -
Bailey
Alpha hydroxy acids (AHA's) and cosmetic
information for consumers via the
FDA CFSAN website
Principal Investigator -
Bailey
AHA Literature Review
Principal Investigator -
Merkatz
STD Workshop- Conference and Summary,
Winter 1994
Principal Investigator -
Fein
Infant Feeding Practices database
(collection, support & construction)
Principal Investigator -
Langone
"FDA Alternatives to silicone breast
implants"- Workshop October 1994
Principal Investigator -
James
"Mechanisms of immunotoxicity and
carcinogenicity associated with silicone
implants" FDA Science Fair, December
1996
Principal Investigator -
James
"Mechanisms of immunotoxicity and
carcinogenicity associated with silicone
implants" Presentation to the Association
of Cancer Research, 1997 Annual meeting
Principal Investigator -
Leighton.
Book chapter in Hormones and growth
factors in development and neoplasia.
Chapter title: "Progresterone receptor
and development" (Leighton &
LL Wei)
FISCAL YEAR 1995
Principal Investigator -
Rheinstein.
Research involving human subjects
(RIHSC) -workshop
Principal Investigator -
Toigo
Women in clinical trials (pilot database)
Principal Investigator -
Ward-Groves
Mammography workshops on MQSA facilities
Principal Investigator -
Weiss
Profile of Drug Use in Pregnancy
in an HMO- summary report
FISCAL YEAR 1996
Principal Investigator -
Ediger
"Development of a safe, economical
assay for silicone contamination
in blood & tissue" Presentation
to the Biophonics 1997 Conference,
California.
Principal Investigator -
Ediger
"Lasers in Medicine and Biology"
Presentation, Gordon Conference,
July 1996.
Principle Investigator -
Toigo
"Eligibility of women to participate
in clinical trials: pilot tracking
system" Poster at the FDA Forum of
Regulatory Sciences, 1997.
Principle Investigator -
Toigo
"Eligibility of women to participate
in clinical trials" - Oral Presentation
to Commissioned Officers; Association
of Public Health Conference, June
1998
Principle Investigator -
Silberberg
Guidance for Industry: Uniform Contraceptive
labeling (chart)
Principle Investigator -
Greberman
"The transfer of defence, intelligence
and space technologies for early
detection and control of cancers
in women" Workshop 1996
Principle Investigator -
Myers.
"Opportunities for industrial collaboration
in contraceptive research" Poster
presentation, Durham, N.C. 1996
Principle Investigator -
Brown
Silicone gel breast implant rupture.
Brown SL, Brinton LA. USPHS Commissioned
Officers Association 33rd Annual
Meeting, Alexandria, VA, 1998.
Principle Investigator -
Brown
Silicone gel breast implant rupture
study. Brown SL, Brinton LA. American
Public Health Association, 126th
Annual Meeting and Exposition, page
179. (November,1998).
Principle Investigator -
Brown
Silicone gel breast implant rupture
study. Brown SL, Pennello G. 1998
FDA Science Forum (December, 1998).
Principle Investigator -
Brown
FDA study on breast implant rupture
and self report of resurgery. Brown
SL. USPHS Commissined Officers Association
34th Annual Meeting, Alexandria,
VA, 1999.
Principle Investigator -
Brown
FDA study on breast implant surgery
and replacement. Brown SL, Middleton
MS, Berg WA , Soo MS, Pennello G.
Plastic Surgical Forum 68th Annual
Meeting, XXII:179-80.
Principle Investigator -
Brown
Silicone gel breast implant rupture
prevalence by magnetic resonance
imaging (MR) in a population of women
in Birmingham, Alabama. Brown SL,
Middleton MS, Berg WA Soo MS, Pennello
G. 2000 FDA Science Forum
Principle Investigator -
Brown
Replacement surgery and silicone
gel breast implant rupture:self-report
by women after mammoplasty. Brown
SL, Pennello G. 2000 FDA Science
Forum
Principle Investigator -
Brown
Health status in women with silicone
gel breast implant rupture or extracapsular
silicone. Brown SL, Pennello G, Berg
WA, et al. 2000 FDA Science Forum.
Principle Investigator -
Brown
Modeling rupture rates of silicone
gel breast implants. Pennello G,
Brown SL, Natarajan R, Feigal D.
2000 FDA Science Forum.
Principle Investigator -
Brown
CDRH Science Seminar Grand Rounds.
FDA study on silicone gel breast
implant rupture prevalence. Brown
SL. March, 2000.
Principle Investigator -
Brown
FDA study of silicone gel breast
implant rupture. Brown SL. Sixth
World Congress Biomaterials Congress.
Kamuela, Hawaii. Invited speaker.
Principle Investigator -
Brown
Consensus of MR imaging readings
for 571 single-lumen silicone gel-filled
breast implants in the women's health
bBreast implant rupture study Middleton
MS, Berg WA, Soo MS, Brown SL, Pennello
G. (submitted to Radiological Society
of North America - RSNA)
Principle Investigator -
Brown
Berg WA, Middleton MS, Soo MS, Brown
SL. Consensus evaluations of the
MR imaging appearance of soft-tissue
extracapsular silicone in the women's
health breast implant study for 344
women with 687 single- and double-lumen
implants (Submitted to RSNA)
Principle Investigator -
Brown
Rupture prevalence and MR imaging
appearance of the Hartley double-lumen
breast implant. Middleton MS, Soo
MS, Berg WA, Brown SL, Pennello G.
(Submitted to RSNA)
FISCAL YEAR 1997
Principle Investigator -
Marinac-Dabic
"Six month follow up of women treated
with the Palmaz-Schatz stent" American
Public Health Association Annual
meeting, November 1998.
Principle Investigator -
Szarfman
"Datamining methods to screen FDA's
post-marketing safety database" Seminar
to FDA Staff college by William DuMouchel,
PhD and Ana Szarfman, Ph.D., MD.
Principle Investigator -
Ana Szarfman
"Bayesian datamining in large frequency
tables, with an application to the
FDA spontaneous reporting system"-
A commentary. The American Statistician,
August 1999.
Principle Investigator -
Marinac-Dabic
"Epidemiology of medical devices
used in women" Annuals of Epidemiology
and Epidemiology (supplements).
Principle Investigator -
Bright
"Does managed care equalized access
for poor elderly?: socioeconomic
status and utilization in a managed
care HMO. Presentation to the 14th
International Conference on Pharmacoepidemiology,
Fall 1998.
FISCAL YEAR 1998
Principle Investigator -
Sheehan
"The Endocrine Disruptor Knowledge
Base: A Prototype Toxicological Knowledge
Base and Predictive Models for Endocrine
Disrupting Componds." Perkins R,
Anson JF, Blair R, et. al In: Society
of Environmental Toxicology and Chemistry,
8th International Workshop on Quantitative
Structure Activity Relationships
(QSARs) in the Environmental Sciences,
Baltimore, Maryland, 1998.
Principle Investigator -
Neunaber Kerr
"Characterization and creation of
defects in condoms" Laboratory Information
bulletin No. 4-184.
Principle Investigator -
Neunaber Kerr
"The Evaluation of various papers
for usefulness in condom water leak
testing" Laboratory Information bulletin
No. 4-152.
Principle Investigator -
Neunaber Kerr
"The Evaluation of various papers
for usefulness in condom water leak
testing" Abstract at the FDA Regulatory
Science Forum, Washington, D.C.,
January 2000.
Principle Investigator -
Wear
"Relationship between attenuation
and backscatter in trabecular bone",
KA Wear, p. 56, Proc. 24th International
Symp. On Ultrasonic Imaging and Tissue
Characterization, Arlington, VA,
June 2-4, 1999.
Principle Investigator -
Wear
"Comparison of phase and group velocities
in trabecular bone", KA Wear, accepted
for presentation at the 25th International
Symp. On Ultrasonic Imaging and Tissue
Characterization, Arlington, VA,
May 22-24, 2000