Search Strategy—Beneficial Effects

1. Initial MEDLINE search: 1,282 articles.

2. Review of abstracts.

• 1,274 excluded on abstract review as not meeting inclusion criteria.

3. 8 unique trials for reviews

• Excluded 3 trials: (1) Silagy²¹: no measure of benefits, (2) ETDRS¹²: mixed population (> 10% with CVD), (3) SAPAT¹³: mixed population (> 10% with CVD)

4. 5 final trials included in review: BMD⁵, PHS⁴, TPT⁷, HOT⁸, PPP⁹.

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