According to the 2000-2001 Regional Differences in Indian Health 31.4 percent of all deaths in the U.S. were caused by diseases of the heart followed by Malignant Neoplasms, Cerebrovascular diseases, Chronic Obstructive Pulmonary Diseases and then Unintentional Injuries.

As noted in the 2000-2001 Regional Differences in Indian Health, 21.6 percent of all deaths in the IHS service area were caused by diseases of the heart, followed by Malignant Neoplasms, Unintentional Injuries, Diabetes Mellitus, and Chronic Liver Disease & Cirrhosis.

The five leading causes of AI/AN youth for ages 1 to 4 were unintentional injuries, Congenital Anomalies, Homicide and Legal Intervention, Malignant Neoplasms, and Diseases of the Heart

The five leading causes of AI/AN youth for infants (births to under 1 year) were Congenital Anomalies, Sudden Infant Death Syndrome, Disorders Relating to Short Gestation and Low Birthweight, Unintentional Injuries, and Pneumonia and Influenza.