Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase III Treatment Active 18 and over NCI RTOG-0525 RTOG-0525, EORTC-26052, EORTC-22053, NCT00304031

Objectives

Primary

1. Determine if dose-intensifying (increasing the “dose-density”) the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival of patients with newly diagnosed glioblastoma or gliosarcoma.

Secondary

1. Determine if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by progression-free survival.
2. Determine in patients with unmethylated MGMT if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy (overall and progression-free survival) compared with patients receiving conventional temozolomide dosing.
3. Determine in patients with methylated MGMT if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy (overall and progression-free survival) compared with patients receiving conventional temozolomide dosing.
4. Determine if there is an association between tumor MGMT gene methylation status and treatment response.
5. Compare and record the toxicities of the conventional and dose-intense chemotherapy regimens.
6. Evaluate whether 6-month progression-free survival is associated with overall survival.

Entry Criteria

Disease Characteristics:

• Histologically proven glioblastoma or gliosarcoma
  • Diagnosis must be made by open biopsy or tumor resection
    • Diagnosis by stereotactic biopsy not allowed
  • Tumor must have supratentorial component
  • Contrast-enhanced MRI or CT scan (if MRI is not available) of the brain must be performed preoperatively and postoperatively prior to initiation of radiotherapy, within 28 days prior to study entry
    • If pre- and postoperative contrast-enhanced CT scans are obtained, must be of sufficient quality



• Meets 1 of the following recursive positioning analysis classifications:
  • Class III
    • Age < 50 years
    • Karnofsky performance status (KPS) 90-100%
  • Class IV, meeting 1 of the following criteria:
    • Age < 50 years and KPS < 90%
    • Age ≥ 50 years and underwent prior partial or total tumor resection with no worse than minor neurofunction impairment
  • Class V, meeting 1 of the following criteria:
    • Age ≥ 50 years and underwent prior partial or total tumor resection with worse than minor neurofunction impairment
    • Age ≥ 50 years and underwent prior tumor biopsy only
    • Age ≥ 50 years, KPS 60-100%, and normal mental status



• Underwent surgery to remove the brain tumor within the past 5 weeks



• No recurrent or multifocal malignant gliomas



• At least 1 block of tissue available for analysis of MGMT gene methylation status



• No metastases detected below the tentorium or beyond the cranial vault

Prior/Concurrent Therapy:

• See Disease Characteristics
• Recovered from the effects of surgery, postoperative infection, and other complications prior to study entry
• No prior chemotherapy or radiosensitizers (including polifeprosan 20 with carmustine implant [Gliadel wafers] or any other intratumoral or intracavitary treatment) for cancers of the head and neck region
  • Prior chemotherapy for a different cancer is allowed
• No prior radiotherapy to the head or neck (except for T1 glottic cancer) that resulted in an overlap of radiation fields
• No participation in other therapeutic clinical protocols within 30 days prior to study entry or during participation in the study
• No concurrent prophylactic growth factors
• No other concurrent investigational drugs
• No concurrent surgical procedures for tumor debulking
• No other concurrent chemotherapy, immunotherapy, or biologic therapy
• No additional concurrent stereotactic boost radiotherapy
• No concurrent intensity-modulated radiotherapy
• Concurrent steroids allowed provided dose is stable or decreasing in the past 5 days

Patient Characteristics:

• KPS 60-100%
• Absolute neutrophil count ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Hemoglobin ≥ 10 g/dL (transfusion or other intervention allowed)
• BUN ≤ 25 mg/dL
• Creatinine ≤ 1.7 mg/dL
• Bilirubin ≤ 2.0 mg/dL
• AST and ALT ≤ 3 times normal
• Negative pregnancy test
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No prior invasive malignancy (except for nonmelanomatous skin cancer) unless patient is disease-free for ≥ 3 years (e.g., carcinoma in situ of the breast, oral cavity, or cervix allowed)
• No severe, active comorbidity, including any of the following:
  • Unstable angina and/or congestive heart failure requiring hospitalization
  • Transmural myocardial infarction within the last 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
  • Known hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
  • Known AIDS based upon current CDC definition
  • Major medical illnesses or psychiatric impairments that, in the investigator's opinion, will prevent administration or completion of protocol therapy
  • Active connective tissue disorders, such as lupus or sclerodema that, in the opinion of the treating physician, may put the patient at high risk for radiation toxicity
• No prior allergic reaction to temozolomide

Expected Enrollment

A total of 834 patients will be accrued for this study.

Outcomes

Overall survival (OS)

Progression-free survival (PFS)
Comparison of OS and PFS in patients with unmethylated MGMT
Comparison of OS and PFS in patients with methylated MGMT
Correlation of tumor MGMT gene methylation status with treatment response
Toxicity
Correlation of PFS with OS at 6 months

Outline

This is a randomized, multicenter study. Patients are stratified according to recursive partitioning analysis class (III vs IV vs V) and MGMT gene methylation status (methylated vs nonmethylated vs indeterminate).

Patients undergo radiotherapy daily, 5 days per week for 6 weeks. Patients also receive oral temozolomide daily during radiotherapy. Patients are then randomized to 1 of 2 treatment arms. Treatment begins 4 weeks after completion of radiotherapy.

• Arm I: Patients receive oral temozolomide on days 1-5.



• Arm II: Patients receive oral temozolomide on days 1-21.

In both arms, treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding disease may receive up to 6 more courses of temozolomide.

After completion of study treatment, patients are followed every 3 months for 1 year, every 4 months for 2 years, and then every 6 months thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

Mark Gilbert, MD, Protocol chair		Ph: 713-792-8288; 800-392-1611 Email: mrgilbert@mdanderson.org
Minesh Mehta, MD, Protocol co-chair		Ph: 608-263-5009; 800-622-8922 Email: mehta@humonc.wisc.edu

European Organization for Research and Treatment of Cancer

Roger Stupp, MD, Protocol chair		Ph: 41-21-314-0156 Email: roger.stupp@chuv.ch

U.S.A.
Alaska
	Fairbanks
	Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
		Huong Pham, MD	Ph:  206-223-6801
Arizona
	Phoenix
	Arizona Oncology Services Foundation
		David Brachman, MD, FACRO	Ph:  602-406-3170
	Scottsdale
	Mayo Clinic Scottsdale
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Tucson
	Arizona Cancer Center at University of Arizona Health Sciences Center
		Clinical Trials Office - Arizona Cancer Center at University of Arizona Health Sciences Center	Ph:  520-626-9008
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Christopher Jones, MD	Ph:  916-888-1266
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-2866
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Christopher Jones, MD	Ph:  916-622-9700
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Christopher Jones, MD	Ph:  916-904-3440
	Duarte
	City of Hope Comprehensive Cancer Center
		Clinical Trials Office - City of Hope Comprehensive Cancer Center	Ph:  800-826-4673
			Email: becomingapatient@coh.org
	Greenbrae
	Marin Cancer Institute at Marin General Hospital
		David Irwin, MD	Ph:  510-204-2866
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-2866
	Mission Hills
	Providence Holy Cross Cancer Center
		Nancy Ellerbroek, MD	Ph:  818-898-4410
	Pomona
	Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
		Clinical Trials Office - Robert and Beverly Lewis Family Cancer Care Center	Ph:  909-865-9555
	Roseville
	Radiation Oncology Center - Roseville
		Christopher Jones, MD	Ph:  916-969-4422
	Sacramento
	Mercy General Hospital
		Christopher Jones, MD	Ph:  916-453-4453
	Radiological Associates of Sacramento Medical Group, Incorporated
		Christopher Jones, MD	Ph:  916-646-8300
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-2866
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
	Vacaville
	Solano Radiation Oncology Center
		Christopher Jones, MD	Ph:  707-447-0400
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-2866
Colorado
	Colorado Springs
	Memorial Hospital Cancer Center - Colorado Springs
		Clinical Trials Office - Memorial Hospital	Ph:  719-365-2406
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Fort Collins
	Front Range Cancer Specialists
		Diana Medgyesy, MD	Ph:  970-212-7600
	Poudre Valley Radiation Oncology
		C. Kelley Simpson, MD	Ph:  970-482-3328
	Pueblo
	St. Mary - Corwin Regional Medical Center
		John Stageberg	Ph:  719-557-4000
Connecticut
	New Haven
	Yale Cancer Center
		Clinical Trials Office - Yale Cancer Center	Ph:  203-785-5702
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Clinical Trials Office - Tunnell Cancer Center	Ph:  302-645-3171
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-733-6227
Florida
	Boca Raton
	Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
		Clinical Trials Office - Eugene M. and Christine E. Lynn Cancer Institute	Ph:  561-955-4800
	Hollywood
	Memorial Cancer Institute at Memorial Regional Hospital
		Clinical Trials Office - Memorial Cancer Institute	Ph:  954-985-3443
	Jacksonville
	Baptist Cancer Institute - Jacksonville
		Clinical Trials Office - Baptist Cancer Institute - Jacksonville	Ph:  904-202-7051
	Integrated Community Oncology Network at Southside Cancer Center
		Douglas Johnson, MD	Ph:  904-202-7020
	Mayo Clinic - Jacksonville
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Jacksonville Beach
	Integrated Community Oncology Network
		Douglas Johnson, MD	Ph:  904-202-7020
	Jascksonville
	Baptist Medical Center South
		Douglas Johnson, MD	Ph:  904-202-7020
	Miami
	Baptist-South Miami Regional Cancer Program
		Andre Abitbol, MD	Ph:  786-596-6566
	Orange Park
	Integrated Community Oncology Network - Orange Park
		Douglas Johnson, MD	Ph:  904-202-7020
	Palatka
	Florida Cancer Center - Palatka
		Douglas Johnson, MD	Ph:  904-202-7020
	Panama City
	Bay Medical
		Hasan Murshed	Ph:  850-747-6972
	Saint Augustine
	Flagler Cancer Center
		Douglas Johnson, MD	Ph:  904-202-7020
	Tampa
	H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
		Clinical Trials Office - H. Lee Moffitt Cancer Center and Reseach Institute	Ph:  800-456-7121
			Email: canceranswers@moffitt.org
Georgia
	Atlanta
	Piedmont Hospital
		Adam Nowlan	Ph:  404-605-5000 866-605-5111
	Columbus
	John B. Amos Cancer Center
		Clinical Trials Office - John B. Amos Cancer Center	Ph:  706-660-6404
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Clinical Trials Office - Curtis and Elizabeth Anderson Cancer Institute	Ph:  912-350-8568
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Clinical Trials Office - Saint Alphonsus Cancer Care Center	Ph:  208-367-7954
Illinois
	Arlington Heights
	Northwest Community Hospital
		Stephen Nigh, MD	Ph:  847-618-6560
	Aurora
	Rush-Copley Cancer Care Center
		Kendrith Rowland, MD	Ph:  217-383-3010
	Canton
	Graham Hospital
		John Kugler, MD	Ph:  309-243-3000
	Carthage
	Memorial Hospital
		John Kugler, MD	Ph:  309-243-3000
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University	Ph:  312-695-1301
			Email: cancer@northwestern.edu
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Effingham
	St. Anthony's Memorial Hospital
		Clinical Trials Office - St. Anthony's Memorial Hospital	Ph:  217-347-1305
	Eureka
	Eureka Community Hospital
		John Kugler, MD	Ph:  309-243-3000
	Galesburg
	Galesburg Clinic, PC
		John Kugler, MD	Ph:  309-243-3000
	Galesburg Cottage Hospital
		John Kugler, MD	Ph:  309-243-3000
	InterCommunity Cancer Center of Western Illinois
		John Kugler, MD	Ph:  309-243-3000
	Havana
	Mason District Hospital
		John Kugler, MD	Ph:  309-243-3000
	Hopedale
	Hopedale Medical Complex
		John Kugler, MD	Ph:  309-243-3000
	Joliet
	Joliet Oncology-Hematology Associates, Limited - West
		Kendrith Rowland, MD	Ph:  217-383-3010
	Macomb
	McDonough District Hospital
		John Kugler, MD	Ph:  309-243-3000
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Clinical Trials Office - Cardinal Bernardin Cancer Center	Ph:  708-226-4357
	Normal
	BroMenn Regional Medical Center
		John Kugler, MD	Ph:  309-243-3000
	Community Cancer Center
		John Kugler, MD	Ph:  309-243-3000
	Ottawa
	Community Hospital of Ottawa
		John Kugler, MD	Ph:  309-243-3000
	Oncology Hematology Associates of Central Illinois, PC - Ottawa
		John Kugler, MD	Ph:  309-243-3000
	Pekin
	Cancer Treatment Center at Pekin Hospital
		John Kugler, MD	Ph:  309-243-3000
	Peoria
	CCOP - Illinois Oncology Research Association
		John Kugler, MD	Ph:  309-243-3000
	Methodist Medical Center of Illinois
		Clinical Trials Office - Methodist Medical Center of Illinois	Ph:  309-243-3000
	Oncology Hematology Associates of Central Illinois, PC - Peoria
		John Kugler, MD	Ph:  309-243-3000
	Proctor Hospital
		John Kugler, MD	Ph:  309-243-3000
	Peru
	Illinois Valley Community Hospital
		John Kugler, MD	Ph:  309-243-3000
	Princeton
	Perry Memorial Hospital
		John Kugler, MD	Ph:  309-243-3000
	Spring Valley
	St. Margaret's Hospital
		John Kugler, MD	Ph:  309-243-3000
	Valley Cancer Center
		John Kugler, MD	Ph:  309-243-3000
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Clinical Trials Office - Carle Cancer Center	Ph:  800-446-5532
	CCOP - Carle Cancer Center
		Clinical Trials Office - CCOP - Carle Cancer Center	Ph:  800-446-5532
Indiana
	Anderson
	Saint John's Cancer Center at Saint John's Medical Center
		Darrel Ross	Ph:  765-646-8459
	Beech Grove
	St. Francis Hospital and Health Centers - Beech Grove Campus
		Howard Gross, MD	Ph:  317-787-3311
	Elkhart
	Elkhart General Hospital
		Janaki Moni, MD	Ph:  517-367-5070
	Fort Wayne
	Parkview Regional Cancer Center at Parkview Health
		David Hornback, MD	Ph:  574-647-7461
	Radiation Oncology Associates Southwest
		Tony Lee	Ph:  260-436-4116
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Kokomo
	Howard Community Hospital
		Janaki Moni, MD	Ph:  517-367-5070
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Janaki Moni, MD	Ph:  517-367-5070
	Michigan City
	Saint Anthony Memorial Health Centers
		Kendrith Rowland, MD	Ph:  217-383-3010
	Richmond
	Reid Hospital & Health Care Services
		Howard Gross, MD	Ph:  765-983-3000
	South Bend
	CCOP - Northern Indiana CR Consortium
		Janaki Moni, MD	Ph:  517-367-5070
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
	Saint Joseph Regional Medical Center
		Janaki Moni, MD	Ph:  517-367-5070
Iowa
	Ames
	McFarland Clinic, PC
		Clinical Trials Office - McFarland Clinic, PC	Ph:  515-239-2621
	Des Moines
	CCOP - Iowa Oncology Research Association
		Roscoe Morton, MD, FACP	Ph:  515-244-7586
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital	Ph:  515-241-8704
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center	Ph:  515-241-6727
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Roscoe Morton, MD, FACP	Ph:  515-244-7586
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Roscoe Morton, MD, FACP	Ph:  515-244-7586
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Roscoe Morton, MD, FACP	Ph:  515-244-7586
	Mercy Capitol Hospital
		Roscoe Morton, MD, FACP	Ph:  515-244-7586
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Cancer Information Service	Ph:  800-237-1225
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa	Ph:  641-422-6304
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Wender, MD, PhD	Ph:  712-252-9326
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-9326
	St. Luke's Regional Medical Center
		Donald Wender, MD, PhD	Ph:  712-252-9326
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Kansas City
	Providence Medical Center
		Rakesh Gaur, MD	Ph:  913-596-4000
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Rakesh Gaur, MD	Ph:  785-840-2800
	Liberal
	Southwest Medical Center
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Overland Park
	Johnson County Radiation Therapy
		Rakesh Gaur, MD	Ph:  913-469-0002
	Kansas City Cancer Centers - Southwest
		Vivek Kavadi	Ph:  913-234-0400
	Menorah Medical Center
		Rakesh Gaur, MD	Ph:  913-498-6000
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Shawnee Mission
	Shawnee Mission Medical Center
		Rakesh Gaur, MD	Ph:  913-676-2000
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Wichita
	Associates in Womens Health, PA - North Review
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	CCOP - Wichita
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Wesley Medical Center
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
Maryland
	Annapolis
	DeCesaris Cancer Institute at Anne Arundel Medical Center
		Ashish Chawla	Ph:  443-481-5800
	Baltimore
	St. Agnes Hospital Cancer Center
		Richard Hudes, MD	Ph:  410-368-2910
	Elkton MD
	Union Hospital Cancer Program at Union Hospital
		Adam Raben, MD	Ph:  302-733-6227
Massachusetts
	Boston
	Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
		Clinical Trials Office - Dana-Farber/Harvard Cancer Center	Ph:  617-582-8480
	Massachusetts General Hospital
		Clinical Trials Office - Massachusetts General Hospital	Ph:  877-726-5130
	Hyannis
	Cape Cod Hospital
		Arnab Chakravarti, MD	Ph:  508-771-1800
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center	Ph:  517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Salam Jafar, MD	Ph:  734-712-3596
	Saint Joseph Mercy Cancer Center
		Salam Jafar, MD	Ph:  734-712-3596
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center	Ph:  313-593-8090
	Detroit
	Josephine Ford Cancer Center at Henry Ford Hospital
		Eleanor Walker, MD	Ph:  313-916-1850 888-734-5322
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Gregory Cooley, MD	Ph:  414-433-8184
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Hurley Medical Center
		Clinical Trials Office - Hurley Medical Center	Ph:  810-762-8057
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Iron Mountain
	Dickinson County Healthcare System
		Gregory Cooley, MD	Ph:  414-433-8184
	Jackson
	Foote Memorial Hospital
		Salam Jafar, MD	Ph:  734-712-3596
	Kalamazoo
	Borgess Medical Center
		Raymond Lord, MD	Ph:  269-373-7488
	Bronson Methodist Hospital
		Raymond Lord, MD	Ph:  269-373-7488
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
	Lambertville
	Haematology-Oncology Associates of Ohio and Michigan, PC
		Paul Schaefer, MD	Ph:  419-843-6147
	Lansing
	Sparrow Regional Cancer Center
		Clinical Trials Office - Sparrow Regional Cancer Center	Ph:  517-364-2890
	Livonia
	St. Mary Mercy Hospital
		Salam Jafar, MD	Ph:  734-712-3596
	Monroe
	Community Cancer Center of Monroe
		Paul Schaefer, MD	Ph:  419-843-6147
	Mercy Memorial Hospital - Monroe
		Paul Schaefer, MD	Ph:  419-843-6147
	Pontiac
	St. Joseph Mercy Oakland
		Salam Jafar, MD	Ph:  734-712-3596
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Salam Jafar, MD	Ph:  734-712-3596
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus	Ph:  248-551-7695
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph:  989-776-8411
	Southfield
	Providence Cancer Institute at Providence Hospital - Southfield Campus
		June Chan	Ph:  248-849-3541 800-341-0801
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Janaki Moni, MD	Ph:  517-367-5070
	Warren
	St. John Macomb Hospital
		Salam Jafar, MD	Ph:  734-712-3596
Minnesota
	Alexandria
		Harold Windschitl, MD	Ph:  320-762-8903 800-835-6624
	Bemidji
	MeritCare Bemidji
		Preston Steen, MD	Ph:  701-234-2397
	Burnsville
	Fairview Ridges Hospital
		Paul Sperduto, MD	Ph:  952-892-2000
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Paul Sperduto, MD	Ph:  763-236-6000
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph:  612-625-3650
	Fergus Falls
		Harold Windschitl, MD	Ph:  218-739-6654
		Harold Windschitl, MD	Ph:  800-237-1225
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Paul Sperduto, MD	Ph:  763-236-5000
	Maplewood
	Minnesota Oncology Hematology, PA - Maplewood
		Paul Sperduto, MD	Ph:  612-779-7978
	Minneapolis
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph:  612-863-5654
	Robbinsdale
	Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center	Ph:  763-520-1893
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Saint Cloud
	CentraCare Clinic - River Campus
		Harold Windschitl, MD	Ph:  320-252-5131
	Coborn Cancer Center
		Harold Windschitl, MD	Ph:  320-229-4907 877-229-4907
	Saint Louis Park
	CCOP - Metro-Minnesota
		Paul Sperduto, MD	Ph:  952-993-1517
	Park Nicollet Cancer Center
		Paul Sperduto, MD	Ph:  952-993-3248
	Saint Paul
	United Hospital
		Paul Sperduto, MD	Ph:  651-241-8000
	Waconia
	Ridgeview Medical Center
		Paul Sperduto, MD	Ph:  952-442-2191 800-967-4620
	Woodbury
	Minnesota Oncology Hematology, PA - Woodbury
		Paul Sperduto, MD	Ph:  651-735-7414
Missouri
	Cape Girardeau
	Cancer Institute of Cape Girardeau, LLC
		Tapan Roy, MD	Ph:  573-334-2230
	Independence
	Independence Regional Health Center
		Rakesh Gaur, MD	Ph:  816-836-8100
	Joplin
	St. John's Regional Medical Center
		Clinical Trials Office - St. John's Regional Medical Center	Ph:  417-625-2488 ext. 2949
	Kansas City
	CCOP - Kansas City
		Rakesh Gaur, MD	Ph:  816-823-0555
	Kansas City Cancer Center at St. Joseph's Medical Mall
		Rakesh Gaur, MD	Ph:  816-942-5800
	Kansas City Cancer Centers - South
		Vivek Kavadi	Ph:  816-333-1326
	North Kansas City Hospital
		Rakesh Gaur, MD	Ph:  816-691-2000
	Parvin Radiation Oncology
		Rakesh Gaur, MD	Ph:  816-452-2751
	Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
		Rakesh Gaur, MD	Ph:  816-505-9100
	Research Medical Center
		Rakesh Gaur, MD	Ph:  816-276-4000
	Saint Luke's Cancer Institute at Saint Luke's Hospital
		Rakesh Gaur, MD	Ph:  816-932-9007
	St. Joseph Medical Center
		Rakesh Gaur, MD	Ph:  816-942-4400
	Truman Medical Center - Hospital Hill
		Rakesh Gaur, MD	Ph:  816-404-0000
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur, MD	Ph:  816-271-7280
	Saint Louis
	Arch Medical Services, Incorporated at Center for Cancer Care and Research
		Alan Lyss, MD	Ph:  314-628-1210
	Missouri Baptist Cancer Center
		Alan Lyss, MD	Ph:  314-996-5569 800-392-0936
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Joseph Simpson, MD, PhD	Ph:  314-747-7222 800-600-3606
	Saint Peters
	Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
		Joseph Simpson, MD, PhD	Ph:  636-916-9920
	Springfield
	CCOP - Cancer Research for the Ozarks
		Robert Carolla	Ph:  417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert Carolla	Ph:  417-269-5257
	St. John's Regional Health Center
		Robert Carolla	Ph:  417-820-2000
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-259-2245 800-361-3239
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Marchello, MD	Ph:  406-238-6290 800-648-6274
	Northern Rockies Radiation Oncology Center
		Benjamin Marchello, MD	Ph:  406-248-2212 800-358-8818
	St. Vincent Healthcare Cancer Care Services
		Benjamin Marchello, MD	Ph:  406-657-7000
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-585-5070
	Butte
	St. James Healthcare Cancer Care
		Benjamin Marchello, MD	Ph:  406-723-2500
	Great Falls
		Benjamin Marchello, MD
	Big Sky Oncology
		Clinical Trail Office - Big Sky Oncology	Ph:  406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-454-2171 800-421-1649
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-455-2820
	Havre
	Northern Montana Hospital
		Benjamin Marchello, MD	Ph:  406-265-2211 800-352-5097
	Helena
	St. Peter's Hospital
		Benjamin Marchello, MD	Ph:  406-442-2480
	Kalispell
	Glacier Oncology, PLLC
		Benjamin Marchello, MD	Ph:  406-752-7600
	Kalispell Medical Oncology at KRMC
		Benjamin Marchello, MD	Ph:  406-752-8900
	Kalispell Regional Medical Center
		Benjamin Marchello, MD	Ph:  406-752-5111
	Missoula
	Community Medical Center
		Benjamin Marchello, MD	Ph:  406-728-4100
	Guardian Oncology and Center for Wellness
		Benjamin Marchello, MD	Ph:  406-721-1118
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center	Ph:  406-329-7029
	Montana Cancer Specialists at Montana Cancer Center
		Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center	Ph:  406-238-6962
Nebraska
	Kearney
	Good Samaritan Cancer Center at Good Samaritan Hospital
		Clinical Trials Office - Good Samaritan Cancer Center at Good Samaritan Hospital	Ph:  308-865-7963
	Lincoln
	Cancer Resource Center - Lincoln
		Alan Berg, MD	Ph:  402-420-7000
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center	Ph:  402-398-6060
	CCOP - Missouri Valley Cancer Consortium
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Creighton University Medical Center
		Clinical Trials Office - Creighton University Medical Center	Ph:  402-280-4100
	Immanuel Medical Center
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
	Nevada Cancer Institute
		Clinical Trials Office - Nevada Cancer Institute	Ph:  702-822-5136
	University Medical Center of Southern Nevada
		John Ellerton, MD, CM	Ph:  702-383-2000
New Hampshire
	Concord
	Dartmouth - Hitchcock Concord
		Thomas Sheldon	Ph:  603-226-2200
	Exeter
	Center for Cancer Care at Exeter Hospital
		Danny Sims	Ph:  603-580-6636
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Alan Hartford, MD, PhD	Ph:  603-354-5400
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
New Jersey
	Livingston
	St. Barnabas Medical Center Cancer Center
		Clinical Trials Office - St. Barnabas Medical Center Cancer Center	Ph:  973-322-2470
	Long Branch
	Monmouth Medical Center
		Clinical Trials Office - Monmouth Medical Center	Ph:  732-923-7689
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Maria Werner-Wasik, MD	Ph:  215-955-7679
	Toms River
	J. Phillip Citta Regional Cancer Center at Community Medical Center
		Clinical Trials Office - J. Phillip Citta Regional Cancer Center at Community Medical Center	Ph:  732-818-3882
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
New York
	Brooklyn
	New York Methodist Hospital
		Hani Ashamalla, MD, FCCP	Ph:  718-780-3677
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	Manhasset
	CCOP - North Shore University Hospital
		John DelRowe, MD	Ph:  516-562-4815
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital	Ph:  516-734-8900
	New Hyde Park
	Long Island Jewish Medical Center
		John DelRowe, MD	Ph:  516-562-4815
	New York
	Memorial Sloan-Kettering Cancer Center
		Andrew Lassman	Ph:  212-639-2000 800-525-2225
	Oceanside
	South Nassau Communities Hospital
		Jai Grewal	Ph:  516-632-2030 877-768-8462
	Rochester
	Highland Hospital of Rochester
		Paul Okunieff, MD	Ph:  585-473-2200
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Paul Okunieff, MD	Ph:  585-275-5345
	Lipson Cancer and Blood Center at Rochester General Hospital
		Meri Atanas	Ph:  585-922-4020
North Carolina
	Asheville
	Mission Hospitals - Memorial Campus
		Clinical Trials Office - Mission Hospitals - Memorial Campus	Ph:  828-213-4150
	Rutherfordton
	Rutherford Hospital
		James Bearden, MD	Ph:  864-560-6812
North Dakota
	Bismarck
	Bismarck Cancer Center
		Edward Wos, DO	Ph:  701-323-5741
	Medcenter One Hospital Cancer Care Center
		Edward Wos, DO	Ph:  701-323-5741
	Mid Dakota Clinic, PC
		Clinical Trials Office - Mid Dakota Clinic, PC	Ph:  701-530-6950
	St. Alexius Medical Center Cancer Center
		Clinical Trials Office - St. Alexius Medical Center Cancer Center	Ph:  701-530-6950
	Fargo
	CCOP - MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	MeritCare Broadway
		Preston Steen, MD	Ph:  701-234-2397
	Grand Forks
	Altru Cancer Center at Altru Hospital
		Clinical Trails Office - Altru Cancer Center at Altru Hospital	Ph:  701-780-6520
	Minot
	Trinity CancerCare Center
		Kevin Collins, MD	Ph:  701-857-3535
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Bellefontaine
	Mary Rutan Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Bowling Green
	Wood County Oncology Center
		Paul Schaefer, MD	Ph:  419-843-6147
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hospital	Ph:  330-363-6891
	Chillicothe
	Adena Regional Medical Center
		Clinical Trials Office - Adena Regional Medical Center	Ph:  877-779-7585
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Kevin Redmond, MD	Ph:  513-584-9089
	Cleveland
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Columbus
	CCOP - Columbus
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Doctors Hospital at Ohio Health
		Clinical Trials Office - Doctors Hospital at Ohio Health	Ph:  614-566-3275
	Grant Medical Center Cancer Care
		Clinical Trials Office - Grant Medical Center Cancer Care	Ph:  614-566-4475
	Mount Carmel Health - West Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Riverside Methodist Hospital Cancer Care
		Clinical Trials Office - Riverside Methodist Hospital Cancer Care	Ph:  614-566-4475
	Dayton
	CCOP - Dayton
		Howard Gross, MD	Ph:  937-395-8678
	David L. Rike Cancer Center at Miami Valley Hospital
		Clinical Trials Office - David L. Rike Cancer Center at Miami Valley Hospital	Ph:  937-208-2079
	Good Samaritan Hospital
		Howard Gross, MD	Ph:  937-278-2612
	Grandview Hospital
		Howard Gross, MD	Ph:  937-226-3200
	Samaritan North Cancer Care Center
		Howard Gross, MD	Ph:  937-279-5800 800-616-6784
	Veterans Affairs Medical Center - Dayton
		Howard Gross, MD	Ph:  937-268-6511
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Findlay
	Blanchard Valley Medical Associates
		Howard Gross, MD	Ph:  419-424-0380
	Franklin
	Middletown Regional Hospital
		Howard Gross, MD	Ph:  513-424-2111
	Independence
	Community Oncology Group at Cleveland Clinic Cancer Center
		John Suh, MD	Ph:  216-444-5574
	Kettering
	Charles F. Kettering Memorial Hospital
		Clinical Trials Office - Charles F. Kettering Memorial Hospital	Ph:  937-298-3399 ext. 57556
	Lancaster
	Fairfield Medical Center
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Lima
	Lima Memorial Hospital
		Paul Schaefer, MD	Ph:  419-843-6147
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Maumee
	Northwest Ohio Oncology Center
		Paul Schaefer, MD	Ph:  419-843-6147
		Paul Schaefer, MD	Ph:  419-843-6147
	St. Luke's Hospital
		Paul Schaefer, MD	Ph:  419-843-6147
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Oregon
	St. Charles Mercy Hospital
		Paul Schaefer, MD	Ph:  419-843-6147
	Toledo Clinic - Oregon
		Paul Schaefer, MD	Ph:  419-843-6147
	Salem
	Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
		William Demas, MD	Ph:  330-375-3557
	Sandusky
	North Coast Cancer Care, Incorporated
		Paul Schaefer, MD	Ph:  419-843-6147
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Mercy Medical Center
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Steubenville
	Tony Teramana Cancer Center
		David Parda	Ph:  740-264-8700
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph:  419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Paul Schaefer, MD	Ph:  419-843-6147
	Toledo
	CCOP - Toledo Community Hospital
		Paul Schaefer, MD	Ph:  419-843-6147
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Center	Ph:  419-383-6583
	St. Vincent Mercy Medical Center
		Paul Schaefer, MD	Ph:  419-843-6147
	Toledo Clinic, Incorporated - Main Clinic
		Paul Schaefer, MD	Ph:  419-843-6147
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph:  419-824-1842
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Clinical Trials Office - UVMC Cancer Care Center at Upper Valley Medical Center	Ph:  937-440-4842
	Wauseon
	Fulton County Health Center
		Clinical Trials Office - Fulton County Health Center	Ph:  419-330-2708
	West Chester
	Precision Radiotherapy at University Pointe
		Kevin Redmond, MD	Ph:  513-584-9089
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler, MD, PhD	Ph:  614-488-2118
	Wooster
	Cancer Treatment Center
		Clinical Trials Office - Cancer Treatment Center	Ph:  330-375-4221
	Xenia
	Ruth G. McMillan Cancer Center at Greene Memorial Hospital
		Howard Gross, MD	Ph:  937-352-2140
	Zanesville
	Genesis - Good Samaritan Hospital
		Clinical Trials Office - Genesis - Good Samaritan Hospital	Ph:  740-454-5232
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Terence Herman	Ph:  405-271-6822
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Robert Swanson, MD	Ph:  918-494-1585
Oregon
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
	Gresham
	Legacy Mount Hood Medical Center
		Clinical Trials Office - Legacy Mount Hood Medical Center	Ph:  503-413-2150
	Milwaukie
	Providence Milwaukie Hospital
		Keith Lanier, MD	Ph:  503-513-8300
	Portland
	Adventist Medical Center
		Keith Lanier, MD	Ph:  503-257-2500
	CCOP - Columbia River Oncology Program
		Keith Lanier, MD	Ph:  503-216-6260
	Legacy Emanuel Hospital and Health Center and Children's Hospital
		Clinical Trials Office - Legacy Emanuel Hospital and Health Center and Children's Hospital	Ph:  503-413-8199
	Legacy Good Samaritan Hospital & Comprehensive Cancer Center
		Clinical Trials Office - Legacy Good Samaritan Hospital & Comprehensive Cancer Center	Ph:  503-413-1742
	Providence Cancer Center at Providence Portland Medical Center
		Clinical Trials Office - Providence Cancer Center at Providence Portland Medical Center	Ph:  503-215-6412
	Providence St. Vincent Medical Center
		Clinical Trials Office - Providence St. Vincent Medical Center	Ph:  503-215-6412
	Salem
	Salem Hospital Regional Cancer Care Services
		Clinical Trials Office - Salem Hospital Regional Cancer Care Services	Ph:  503-561-2618
	Tualatin
	Legacy Meridian Park Hospital
		Clinical Trials Office - Legacy Meridian Park Hospital	Ph:  503-413-1742
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
	Allentown
	Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
		Suresh Nair, MD	Ph:  610-402-0500
	Beaver
	UPMC Cancer Center at Beaver Medical Center
		Frank Lieberman, MD	Ph:  412-692-2600
	Bethlehem
	St. Luke's Cancer Network at St. Luke's Hospital
		Nimisha Deb, MD	Ph:  610-954-4300
	Bryn Mawr
	Bryn Mawr Hospital
		Clinical Trials Office - Bryn Mawr Hospital	Ph:  610-645-2680
	Clairton
	UPMC Cancer Center at Jefferson Regional Medical Center
		Frank Lieberman, MD	Ph:  412-692-2600
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Drexel Hill
	Delaware County Regional Cancer Center at Delaware County Memorial Hospital
		Rachelle Lanciano, MD	Ph:  610-284-8240
	East Stroudsburg
	Dale and Frances Hughes Cancer Center at Pocono Medical Center
		Maria Werner-Wasik, MD	Ph:  215-955-7679
	Greensburg
	UPMC Cancer Center - Arnold Palmer Pavilion
		Frank Lieberman, MD	Ph:  412-692-2600
	Hermitage
	Sharon Regional Cancer Care Center- Hermitage
		David Parda	Ph:  724-983-5901
	Hershey
	Penn State Cancer Institute at Milton S. Hershey Medical Center
		Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center	Ph:  717-531-3779
			Email: CTO@hmc.psu.edu
	Johnstown
	UPMC Cancer Center at the John P. Murtha Pavilion
		Frank Lieberman, MD	Ph:  412-692-2600
	McKeesport
	UPMC Cancer Center at UPMC McKeesport
		Clinical Trials Office - UPMC Cancer Center at UPMC McKeesport	Ph:  412-647-8073
	Media
	Riddle Memorial Hospital Cancer Center
		Maria Werner-Wasik, MD	Ph:  215-955-7679
	Monroeville
	Intercommunity Cancer Center
		David Parda	Ph:  412-856-7740
	Moon Township
	UPMC - Moon
		Frank Lieberman, MD	Ph:  412-692-2600
	Natrona Heights
	Alle-Kiski Medical Center
		David Parda	Ph:  724-224-5100
	UPMC Cancer Center - Natrona Heights
		Frank Lieberman, MD	Ph:  412-692-2600
	New Castle
	Jameson Memorial Hospital - North Campus
		Frank Lieberman, MD	Ph:  412-692-2600
	Paoli
	Cancer Center of Paoli Memorial Hospital
		Clinical Trials Office - Cancer Center of Paoli Memorial Hospital	Ph:  610-648-1637
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Frankford Hospital Cancer Center - Torresdale Campus
		Maria Werner-Wasik, MD	Ph:  215-955-7679
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	Pittsburgh
	Allegheny Cancer Center at Allegheny General Hospital
		David Parda	Ph:  412-359-3336 866-680-0004
	Mercy Cancer Institute at Mercy Hospital
		Frank Lieberman, MD	Ph:  412-692-2600
	UPMC - Shadyside
		Clinical Trials Office - UPMC - Shadyside	Ph:  412-621-2334
	UPMC Cancer Center - Upper St. Clair
		Frank Lieberman, MD	Ph:  412-692-2600
	UPMC Cancer Center at Magee-Womens Hospital
		Clinical Trials Office - UPMC Cancer Center at Magee-Womens Hospital	Ph:  412-647-2811
	UPMC Cancer Center at UPMC Passavant
		Clinical Trials Office - UPMC Cancer Center at UPMC Passavant	Ph:  412-367-6454
	UPMC Cancer Center at UPMC Presbyterian
		Clinical Trial Office - UPMC Cancer Center at UPMC Presbyterian	Ph:  412-647-2811
	UPMC Cancer Center at UPMC St. Margaret
		Frank Lieberman, MD	Ph:  412-692-2600
	Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Clinical Trials Office - McGlinn Family Regional Cancer Center	Ph:  610-988-9323
	Seneca
	UPMC Cancer Center at UPMC Northwest
		Frank Lieberman, MD	Ph:  412-692-2600
	Somerset
	Somerset Oncology Center
		David Parda	Ph:  814-444-1424
	State College
	Geisinger Medical Group - Scenery Park
		Thomas Gergel	Ph:  814-231-4560
	Uniontown
	UPMC Cancer Center - Uniontown
		Frank Lieberman, MD	Ph:  412-692-2600
	Washington
	Washington Hospital Cancer Center
		Frank Lieberman, MD	Ph:  412-692-2600
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center	Ph:  570-271-5251
	Wynnewood
	CCOP - Main Line Health
		Paul Gilman, MD	Ph:  610-645-2649
	Lankenau Cancer Center at Lankenau Hospital
		Paul Gilman, MD	Ph:  610-645-2000
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Eric Eastmo, MD	Ph:  605-719-2360
	Sioux Falls
	Avera Cancer Institute
		Loren Tschetter, MD	Ph:  605-328-8000
	Medical X-Ray Center, PC
		Loren Tschetter, MD	Ph:  605-328-8000
	Sanford Cancer Center at Sanford USD Medical Center
		Clinical Trials Office - Sanford Cancer Center	Ph:  605-328-1367
Tennessee
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Clinical Trials Office - Christine LaGuardia Phillips Cancer Center	Ph:  423-224-5593
	Knoxville
	Thompson Cancer Survival Center
		Clinical Trials Office - Thompson Cancer Survival Center	Ph:  865-541-1812
	Thompson Cancer Survival Center West
		Daniel Scaperoth	Ph:  865-374-3800
	Oak Ridge
	Thompson Cancer Survival Center at Methodist
		Daniel Scaperoth	Ph:  865-481-1871
Texas
	Dallas
	Medical City Dallas Hospital
		Vivek Kavadi	Ph:  972-566-7000
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas	Ph:  866-460-4673; 214-648-7097
	Texas Oncology, PA at Texas Cancer Center Dallas Southwest
		Vivek Kavadi	Ph:  972-709-2580
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	Galveston
	University of Texas Medical Branch
		Clinical Trials Office - University of Texas Medical Branch	Ph:  409-772-1950
	Houston
	M. D. Anderson Cancer Center at University of Texas
		Clinical Trials Office - M. D. Anderson Cancer Center at the University of Texas	Ph:  713-792-3245
	Methodist Hospital
		Pamela New	Ph:  713-441-1010
	Lubbock
	Joe Arrington Cancer Research and Treatment Center
		Clinical Trials Office - Joe Arrington Cancer Research and Treatment Center	Ph:  806-725-8000
			Email: jaccresearch@covhs.org
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
Utah
	American Fork
	American Fork Hospital
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Cedar City
	Sandra L. Maxwell Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Ogden
	Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
		Clinical Trials Office - McKay-Dee Hospital Center	Ph:  801 387-7426
	Provo
	Utah Valley Regional Medical Center - Provo
		Clinical Trials Office - Utah Valley Regional Medical Center - Provo	Ph:  801-357-7965
	Saint George
	Dixie Regional Medical Center - East Campus
		Clinical Trials Office - Dixie Regional Medical Center - East Campus	Ph:  435-688-4167
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at University of Utah	Ph:  801-581-4477
			Email: clinical.trials@hci.utah.edu
	LDS Hospital
		R. Jeffrey Lee, MD	Ph:  801-408-1146
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Utah Cancer Specialists at UCS Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
Vermont
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
	Saint Johnsbury
	Norris Cotton Cancer Center - North
		Alan Hartford, MD, PhD	Ph:  802-473-4100
Virginia
	Fredericksburg
	Fredericksburg Oncology, Incorporated
		Paul Schaefer, MD	Ph:  419-843-6147
	Norfolk
	Sentara Cancer Institute at Sentara Norfolk General Hospital
		Clinical Trials Office - Sentara Cancer Institute at Sentara Norfolk General Hospital	Ph:  757-388-2406
	Norton
	Southwest Virginia Regional Cancer Center at Wellmonth Health
		Malcolm Mathews, MD	Ph:  423-224-3150
	Richmond
	Virginia Commonwealth University Massey Cancer Center
		Clinical Trials Office -Virginia Commonwealth University Massey Cancer Center	Ph:  804-628-1939
Washington
	Bellingham
	St. Joseph Cancer Center
		Robert Cadoff	Ph:  360-738-6701 800-541-7209
	Federal Way
	St. Francis Hospital
		Huong Pham, MD	Ph:  206-223-6801
	Kirkland
	Cascade Cancer Center at Evergreen Hospital Medical Center
		Huong Pham, MD	Ph:  206-223-6801
	Seattle
	CCOP - Virginia Mason Research Center
		Huong Pham, MD	Ph:  206-223-6801
	University Cancer Center at University of Washington Medical Center
		Clinical Trials Office - University Cancer Center at University of Washington Medical Center	Ph:  206-616-8289
	Vancouver
	Southwest Washington Medical Center Cancer Center
		Keith Lanier, MD	Ph:  360-514-2174
	Yakima
	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
		Clinical Trails Office - North Star Lodge Cancer Center	Ph:  509-574-3422
Wisconsin
	Appleton
	Theda Care Cancer Institute
		Clinical Trials Office - Theda Care Cancer Institute	Ph:  920-380-1500
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Gregory Cooley, MD	Ph:  414-433-8184
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Gregory Cooley, MD	Ph:  414-433-8184
	St. Mary's Hospital Medical Center - Green Bay
		Gregory Cooley, MD	Ph:  414-433-8184
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer Center	Ph:  920-433-8889
	Johnson Creek
	UW Cancer Center Johnson Creek
		Minesh Mehta, MD	Ph:  920-699-3500
	La Crosse
	Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Clinical Trials Office - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center	Ph:  608-262-5223
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gregory Cooley, MD	Ph:  414-433-8184
	Menomonee Falls
	Community Memorial Hospital Cancer Care Center
		Christopher Schultz, MD	Ph:  262-257-5100
	Milwaukee
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer Center	Ph:  414-805-4380
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Gregory Cooley, MD	Ph:  414-433-8184
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		James Taylor, MD	Ph:  262-687-5000
	Sturgeon Bay
	Door County Cancer Center at Door County Memorial Hospital
		Gregory Cooley, MD	Ph:  414-433-8184
	Green Bay Oncology, Limited - Sturgeon Bay
		Gregory Cooley, MD	Ph:  414-433-8184
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center	Ph:  262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Clinical Trials Office - University of Wisconsin Cancer Center	Ph:  608-262-5223
Wyoming
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  307-674-6022
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Peter Forsyth	Ph:  403-521-3701
	Edmonton
	Cross Cancer Institute at University of Alberta
		Bassam Abdulkarim	Ph:  780-432-8771
Manitoba
	Winnipeg
	CancerCare Manitoba
		David Eisenstat	Ph:  204-787-2241
New Brunswick
	Saint John
	Saint John Regional Hospital
		Farah Naz	Ph:  506-648-6884
Ontario
	Hamilton
	Margaret and Charles Juravinski Cancer Centre
		Anthony Whitton	Ph:  905-387-9495
	London
	London Regional Cancer Program at London Health Sciences Centre
		David MacDonald	Ph:  519-685-8615
	Ottawa
	Ottawa Hospital Regional Cancer Centre - General Campus
		Shawn Malone	Ph:  613-737-7700 ext. 70209 888-627-5346
	Thunder Bay
	Cancer Care Program at Thunder Bay Regional Health Sciences
		Margaret Anthes	Ph:  807-684-7200
	Toronto
	Princess Margaret Hospital
		Warren Mason	Ph:  416-946-2811
Quebec
	Montreal
	McGill Cancer Centre at McGill University
		Luis Souhami	Ph:  514-398-1444
	Quebec City
	Centre Hospitalier Universitaire de Quebec
		Isabelle Vallieres	Ph:  418-525-4444
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Evgeny Sadikov	Ph:  306-766-2203