Testing Status of Agents at NTP
Asphalt Table B-2
Figure B-1. Tumorigenic response to condensed roofing fumes. (Source: Niemeier et al. [1988].)
APPENDIX B
SUMMARY OF ANIMAL DATA
Table B-2. Skin-painting data for the interscapular region of mice [Niemeier et al. 1988]*
|
Approximate % of tumor-bearing mice† | ||||
|---|---|---|---|---|
| CD-1 mice | C3H/HeJ mice | |||
| Substance tested (50-ml doses) | Not light-exposed | Light-exposed | Not light-exposed | Light-exposed |
| Asphalt:† | ||||
| Type I: | ||||
| 232°C | 13 | 20 | 95 | 81 |
| 316°C | 31 | 19 | 94 | 95 |
| Type III: | ||||
| 232°C | 21 | 15 | 88 | 70 |
| 316°C | 35 | 12 | 82 | 75 |
| Coal-tar pitch:§ | ||||
| Type I: | ||||
| 232°C | 68 | 50 | 88 | 98 |
| 316°C | 64 | 41 | 90 | 92 |
| Type III: | ||||
| 232°C | 62 | 50 | 93 | 95 |
| 316°C | 63 | 39 | 99 | 92 |
|
Combination of Type III asphalat and Type I coal tar (both generated at 316°C) | 50 | 29 | 92 | 94 |
| 1:1 Cyclohexane/acetone | 0 | 2 | 0 | 4 |
| 0.1 BaP | 70 | 25 | 89 | 74 |
* Forty-eight groups were tested. Each contained 50 male CD-1 mice and d50 male C3H/HeJ mice. All groups were treated twice a week for 78 weeks (18 months).
† Half of the 48 groups tested were exposed to simulated sunlight to detect any photochemical reactions.
Diluted with 1:1 cyclohexane/acetone to a concentration of 50% solids (25 mg volatiles/application).
§ Diluted with 1:1 cyclohexane/acetone to a concentration of 0.01% BaP (1.5-4.2 mg volatiles/application).
Web page last updated on August 15, 2005
