Testing Status of Agents at NTP
Asphalt Table 12
Table 12. Induction of histopathologically-confirmed carcinomas in C3H/HeJ and Sencar mice
| Mouse strain | Substance painted on mouse skin | Number of histopathologically confirmed malignant tumors/grp | Number of histopathologically confirmed malignant tumors† | Average time (weeks) to carcinoma |
|---|---|---|---|---|
| C3H/HeJ mice | Raw asphalt | 3 | 3 | 101.3 |
| Neat asphalt fume | 25 | 20 | 73.9 | |
| Fraction B | 10 | 10 | 98.3 | |
| Fraction C | 18 | 17 | 85.6 | |
| Fractions A, B, C, D, E (combined) | 23 | 19 | 75.4 | |
| Fractions A, B (combined) | 8 | 8 | 11.4 | |
| Fractions A, C (combined) | 16 | 11 | 89.6 | |
| Fractions B, C, D, E (combined) | 18 | 15 | 80.7 | |
| Fractions A, B, C, D (combined) | 22 | 18 | 80.0 | |
| Fractions A, B, C, E (combined) | 30 | 21 | 77.4 | |
| Fractions B, C, D (combined) | 22 | 15 | 86.4 | |
| Fractions B, C (combined) | 26 | 24 | 73.4 | |
| Fractions A, C, D, E (combined) | 14 | 14 | 88.6 | |
| Fractions A, B, D, E (combined) | 7 | 7 | 97.3 | |
| 0.01% BaP | 28 | 27 | 55.9 | |
| 0.001% BaP | 3 | 3 | 102.7 | |
| Fraction A + 0.01% BaP | 28 | 23 | 69.4 | |
| Fraction A + 0.001% BaP | 1 | 1 | 105.6 | |
| Fraction A + 0.0001% BaP | 1 | 1 | 106.0 | |
| Fraction D + 0.01% BaP | 34 | 25 | 63.6 | |
| Fraction D + 0.0001% BaP | 1 | 1 | 105.6 | |
| Fraction E + 0.01% BaP | 23 | 23 | 61.3 | |
| Fraction E + 0.001% BaP | 2 | 2 | 105.6 | |
| Solvent control | 0 | 0 | Not applicable | |
| Sencar mice | Neat asphalt fume | 18 | 14 | 82.6 |
| Solvent control | 0 | |||
* Adapted
from Sivak et al. [1989] and Sivak et al. [submitted for publication
1996].
† Thirty mice tested per group.
Web page last updated on August 15, 2005
