Testing Status of Agents at NTP
Asphalt Table 10
Table 10. Incidence and types of tumors induced in CD-1 mice treated dermally with roofing asphalt fume condensatesa.
| Final Histopathology | ||||||
|---|---|---|---|---|---|---|
| Tumor-Bearing Animals | Tumors | |||||
| Material Tested | Sunlight | Benign | Malignant | Papilloma | Squamous Cell Carcinoma | Totalb |
| Type I asphalt @ 232°C | - | 6 | 0 | 12 | 0 | 12 |
| + | 2 | 0 | 3 | 0 | 3 | |
| Type I asphalt @ 316°C | - | 13 | 1 | 18 | 0 | 19 |
| + | 3 | 0 | 3 | 0 | 3 | |
| Type III asphalt @ 232°C | - | 9 | 1 | 11 | 1 | 13 |
| + | 5 | 2 | 5 | 1 | 7 | |
| Type III asphalt @ 316°C | - | 13 | 3 | 17 | 1 | 20 |
| + | 4 | 1 | 5 | 1 | 6 | |
| B(a)P | - | 24 | 11 | 43 | 10 | 58 |
| + | 9 | 3 | 11 | 1 | 18 | |
| Cyclohexane/acetone | - | 0 | ||||
| + | 0 | |||||
a Adapted from Thayer et al. [1981].
b Other tumor types observed included: fibrosarcomas, kerato-acanthomas, fibromas and unclassified benign epitheliomas.
Web page last updated on August 15, 2005
