Francis S. Collins, MD, PhD to step down as Director of NIH's National Human Genome Research Institute. Read NIH press release.
	President George W. Bush signs H.R. 493, the Genetic Information Nondiscrimination Act of 2008. Read press release.
	CDC's National Office of Public Health Genomics announces a new funding opportunity for genomics translation in education, surveillance, and policy interventions. The deadline for final applications is June 6, 2008.
	New report, Infrastructure to Monitor Utilization and Outcomes of Gene-based Applications: An Assessment, released by the Agency for Healthcare Research and Quality on May 21, 2008.
	HuGE What's New May 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and  pharyngeal cancers: a HuGE-GSEC review Varela-Lema L, et al. Genet Med 2008 May

The positives, protocols, and perils of genome-wide association
Neale BM & Purcell S
Am J Med Genet B Neuropsychiatr Genet 2008 May

Patients' understandings and experiences of familial hypercholesterolemia
Weiner K & Durrington PN
Community Genet 2008;11(5):273-82

Population Stratification Bias in the Case-Only Study for Gene-Environment Interactions
Wang LY & Lee WC
Am J Epidemiol 2008 May

Microarray Technology and Applications in the Arena of Genome-Wide Association
Grant SF & Hakonarson H
Clin Chem 2008 May

The genetics and immunopathogenesis of inflammatory bowel disease
Cho JH
Nat Rev Immunol 2008 Jun;8(6):458-66

Polymorphism in methylentetra-hydrofolate reductase gene: important role in diseases
Kiseljakovic E, et al.
Bosn J Basic Med Sci 2008 May;8(2):165-9

Reporting of Human Genome Epidemiology (HuGE) association studies: an empirical assessment
Yesupriya A, et al.
BMC Med Res Methodol 2008 May;8(1):31

Depiction of gene-environment relationships in online medical recommendations
Cheng Y, et al.
Genet Med 2008 May

Health first, genetics second: exploring families' experiences of communicating genetic information
Forrest LE, et al.
Eur J Hum Genet 2008 May

Investigating genetic discrimination in Australia: a large-scale survey of clinical genetics clients
Taylor S, et al.
Clin Genet 2008 May

Outcome measurement in clinical genetics services: a systematic review of validated measures
Payne K, et al.
Value Health 2008 May-2008 Jun;11(3):497-508

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
Florez JC
Diabetologia 2008 May

Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition
Martinez JA, et al.
Asia Pac J Clin Nutr 2008;17 Suppl 1:119-22

Human genetics of the metabolic syndrome
Chuang LM
Asia Pac J Clin Nutr 2008;17 Suppl 1:43-6

Should patients with venous thromboembolism be screened for thrombophilia?
Dalen JE
Am J Med 2008 Jun;121(6):458-63

The impact of genetic outreach education and support to primary care on practitioner's confidence and competence in dealing with familial cancers
Bethea J, et al.
Community Genet 2008;11(5):289-94

Lessons learned while developing a cancer family history campaign in the Columbus, Ohio metropolitan area
Sturm AC, et al.
Community Genet 2008;11(5):304-10

The beliefs, and reported and intended behaviors of unaffected men in response to their family history of prostate cancer
Cowan R, et al.
Genet Med 2008 May

Metabolic rate and vascular function are reduced in women with a family history of type 2 diabetes mellitus
Olive JL, et al.
Metabolism 2008 Jun;57(6):831-7

Gene-Environment Interactions and Familial Relative Risks
Bermejo JL
Hum Hered 2008 May;66(3):170-9

 

Pharmacogenetic Testing for Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphisms: Are We There Yet?
Perera MA, et al.
Pharmacotherapy 2008 Jun;28(6):755-68

Pharmacogenetic testing: not as simple as it seems
Haga SB & Burke W
Genet Med 2008 May

 

Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans
Huang RS, et al.
Pharmacogenet Genomics 2008 Jun;18(6):545-9

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 28, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page