Genomics|Update|2007 September 13

Thursday, September 13, 2007

Volume 19 Number 11

This weekly update provides information about the impact of human genetic research on disease prevention & public health.

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	When is BRCA Genetic Testing for Breast and Ovarian Cancer Appropriate? The U.S. Preventive Services Task Force (USPSTF) recommends against routine referral for BRCA testing if a woman’s
family history does not suggest an increased risk for harmful BRCA mutations. The USPSTF recommends that women with a family history associated with an increased risk for BRCA mutations be referred to suitably trained health care providers. > Read the USPSTF recommendations and clinical considerations.

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Announcements

Genomics In The News

Scientific Literature

HuGE Articles

Back Issues




	New HuGE Review A Meta-Analysis of the Association of N-Acetyltransferase 2 Gene (NAT2) Variants with Breast Cancer (164kb) Heather M. Ochs-Balcom, et al. Am J Epidemiol 2007;166:246–254

	September public health genomics seminar presented by CDC “How do we monitor the impact of genomics on population health?" Sep 20, 2007, Rockville, MD (ENVISION – Atlanta, GA)

The following are headlines from on-line news articles published during the past week.
The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
Free registration required for some articles.

Cancer
New insight into breast cancer development in high-risk women, News-Medical.Net, September 12	Gene mutation helps predict thyroid cancer treatment, Medical News Today, September 10
Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas, EurekAlert, September 10	Microarray provides three genomic guides to breast cancer treatment decisions, Medical News Today, September 7

Diabetes	Ethical, Legal, and Social Issues (ELSI)
Mutations in the insulin gene can cause permanent neonatal diabetes, News-Medical.Net, September 11	Personal genomics and the end of insurance, VentureBeat, September 11

line

Family History	Genetic Testing
Family history has strong effect on cardiac risk, Washington Post, September 7	A genetic test that very few need, marketed to the masses, The New York Times, September 11
	DNA helps pave the way for a specific cure for each individual, San Francisco Chronicle, September 9

line

Other News
Gene in HIV makes hiv-2 susceptible to immune system response, researchers say, Medical News Today, September 13	Caught on camera: 3D images give early warning of genetic disorders in children, Guardian Unlimited, September 10
Gene-drug interactions that lower blood pressure, News-Medical.Net, September 13	Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds, EurekAlert, September 10
Genetic map researchers at show, BBC News, September 12	Study finds evidence of genetic response to diet, The New York Times, September 10
Northwest Genome Engineering Consortium receives NIH grant to study gene repair, Medical News Today, September 12	Genetics forum in Dubai, AME Info, September 9
Coding and noncoding genes are involved in and cooperate in human tumorigenesis, News-Medical.Net, September 11	South Africa: Mbeki to open a science research centre, all Africa.com, September 9
Two girls, one genetic 'blip' and a story of hope and courage, Daily Mail, September 11	Alnylam, Isis form venture to develop gene technology, Bloomberg, September 7
$7.8 million award for autism genetics research, Medical News Today, September 10

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Studies in 3,523 Norwegians (HUNT2) and Meta-Analysis in 11,571 Subjects Indicate that Variants in the HNF4A P2 Region are Associated with Type 2 Diabetes in Scandinavians
Johansson S, et al.
Diabetes 2007 Sep

General Articles

Prediction of individual genetic risk to disease from genome-wide association studies
Wray NR, et al.
Genome Res 2007 Sep

Simulating association studies: a data-based resampling method for candidate regions or whole genome scans
Wright FA, et al.
Bioinformatics 2007 Sep

The role of genetics in stroke
Francis J, et al.
Postgrad Med J 2007 Sep;83(983):590-5

Simultaneously correcting for population stratification and for genotyping error in case-control association studies
Cheng KF & Lin WJ
Am J Hum Genet 2007 Oct;81(4):726-43

Simultaneous discovery and testing of deletions for disease association in SNP genotyping studies
Kohler JR & Cutler DJ
Am J Hum Genet 2007 Oct;81(4):684-99

Studying Genetic Predisposition Among Small-for-Gestational-Age Newborns
Infante-Rivard C
Semin Perinatol 2007 Aug;31(4):213-8

The Genetic Basis of Thyroid Autoimmunity
Jacobson EM & Tomer Y
Thyroid 2007 Sep

Asthma Genetics: From Linear to Multifactorial Approaches
Guerra S & Martinez FD
Annu Rev Med 2007 Sep

Genetic Testing

The impact of clinical and genetic screenings on the management of the multiple endocrine neoplasia type 1
Lourenco-Jr DM, et al.
Clinics 2007;62(4):465-70

Epidermal Growth Factor Receptor Mutation Testing in Lung Cancer: Searching for the Ideal Method
Pao W & Ladanyi M
Clin Cancer Res 2007 Sep;13(17):4954-5

The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test
Schneider SA, et al.
Nat Clin Pract Neurol 2007 Sep;3(9):517-25

Family History

An LRP8 Variant Is Associated with Familial and Premature Coronary Artery Disease and Myocardial Infarction
Shen GQ, et al.
Am J Hum Genet 2007 Oct;81(4):780-91

How common is familial cancer?
Hemminki K, et al.
Ann Oncol 2007 Sep

Evidence of shared risk for Alzheimer's disease and Parkinson's disease using family history
Rosen AR, et al.
Neurogenetics 2007 Sep

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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 12, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

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