New article, “The Continuum of Translation Research in Genomic Medicine: How Can We Accelerate the Appropriate Integration of Human Genome Discoveries into Health Care and Disease Prevention?,”  (148KB) published in the October 2007 issue of Genetics in Medicine. Authors: Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, and Bradley L.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
The genetics of MLL leukemogenesis,  EurekAlert, October 16	A tumor-blocking protein may be key in developing deadly form of pancreatic cancer,  News-Medical.Net, October 14
New insight into Trastuzumab resistance in breast cancer via genetic approach,  Medical News Today, October 16	Study needs sisters of breast cancer patients,  Poughkeepsie Journal, October 14
Enhanced DNA-repair mechanism can cause breast cancer,  EurekAlert, October 15	Breast and colon cancers a "genetic landscape", Medical News Today, October 12

The pharmacogenetics of analgesia
Stamer UM & Stuber F
Expert Opin Pharmacother 2007 Oct;8(14):2235-45

TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
Ferwerda B, et al.
Proc Natl Acad Sci U S A 2007 Oct

Pharmacogenetics of acute lymphoblastic leukemia treatment response
Cunningham L & Aplenc R
Expert Opin Pharmacother 2007 Oct;8(15):2519-31

Genetics and preventive health care
Emery J, et al.
Aust Fam Physician 2007 Oct;36(10):808-11

Rapid and accurate haplotype phasing and missing-data inference for whole-genome  association studies by use of localized haplotype clustering
Browning SR & Browning BL
Am J Hum Genet 2007 Nov;81(5):1084-97

The genetics of hereditary colon cancer
Rustgi AK
Genes Dev 2007 Oct;21(20):2525-38

Genetic Susceptibility to Type II Diabetes and Implications for Antidiabetic Therapy
Moore AF & Florez JC
Annu Rev Med 2007 Oct

A new locus-specific database (LSDB) for mutations in the TGFBR2 gene: UMD-TGFBR2
Frederic MY, et al.
Hum Mutat 2007 Oct

Increased Efficiency of Case-Control Association Analysis by Using Allele-Sharing and Covariate Information
Schmidt S, et al.
Hum Hered 2007 Oct;65(3):154-65

The emotional effects of genetic diseases: Implications for clinical genetics
McAllister M, et al.
Am J Med Genet A 2007 Oct

Genes, endothelial function and cerebral small vessel disease
Markus HS
Exp Physiol 2007 Oct

Genetic background of primary biliary cirrhosis
Tanaka A
Hepatol Res 2007 Oct;37 Suppl 3:S377-83

A High-Throughput Population Screening System for the Estimation of Genetic Risk  for Type 1 Diabetes: An Application for the TEDDY (The Environmental Determinants of Diabetes in the Young) Study
Kiviniemi M, et al.
Diabetes Technol Ther 2007 Oct;9(5):460-72

Screening for familial paragangliomas
Myssiorek D, et al.
Oral Oncol 2007 Oct

Knowledge and Attitudes about Microsatellite Instability Testing among High-Risk  Individuals Diagnosed with Colorectal Cancer
Manne SL, et al.
Cancer Epidemiol Biomarkers Prev 2007 Oct;16(10):2110-7

 

A Prospective Study of Familial versus Sporadic Parkinson's Disease
Papapetropoulos S, et al.
Neurodegener Dis 2007;4(6):424-7

Hypoplastic left heart syndrome is heritable
Hinton RB Jr, et al.
J Am Coll Cardiol 2007 Oct;50(16):1590-5

Family genetics
Barlow-Stewart K, et al.
Aust Fam Physician 2007 Oct;36(10):802-5

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 17, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page