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 Thursday, March 1, 2007     Volume 18   Number 9  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
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Colorectal cancer is the second leading cause of death from cancer in the United States. Family history can help identify individuals at increased risk of colorectal cancer, which could prompt earlier and more frequent screening and monitoring. Read more.

CDC Announcements
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Most published research findings are false--but a little replication goes a long way  This reference links to a non-governmental website (last accessed 2/2008)
Ramal Moonesinghe, Muin J. Khoury, A. Cecile J. W. Janssens
Newly published essay in PLoS Medicine written in response to a recent article by John Ioannidis This reference links to a non-governmental website (last accessed 2/2008).  The essay demonstrates the value of replication of research findings by extending Ioannidis' analyses to calculation of the PPV when multiple studies show statistically significant results.

   
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New CDC request for applications on Improving Public Health Practice through Translation Research (R18)
The purpose of the RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. Components are included from various CDC offices and centers. Genomics translation research priorities include family history, genetic testing, and genetics for early disease detection and intervention.
   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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"Study Points to Genetics in Disparities in Preterm Births"  This reference links to a non-governmental website you will need a free Acrobat reader to view this file(7KB)
(Feb 27) The New York Times reports, "Black women have significantly higher rates of premature birth than white women, and a new study suggests there may be underlying genetic factors even when other known risks are taken into account.”

"Older fathers appear to raise risks of genetic disorders"  This reference links to a non-governmental website
(Feb 28) The International Herald Tribune reports, "When it comes to fertility and the prospect of having normal babies, it has always been assumed that men have no biological clock — that unlike women, they can have it all, at any age."

"Uniform language for describing genes of pathogenic and beneficial microbes"  This reference links to a non-governmental website
(Feb 28) EurekAlert! reports, "An international group of scientists has announced a major expansion of a lingua franca used to describe the activities of genes in living organisms."

“Estrogen Gene Affects Risk Of Breast Cancer, But Not CVD”  This reference links to a non-governmental website
(Feb 28) Science Daily reports, "A large Danish study rebuts the accepted idea that differences in an estrogen gene (ESR1) affect the risk of heart attack and stroke in response to hormone replacement therapy.”

"Gene plus mom's smoking boosts child's asthma risk"
(Feb 27) Reuters Health reports, "Smoking during pregnancy is known to raise a child's future asthma risk, but children with a particular gene variation may be especially vulnerable, a study published Tuesday suggests.”

"Black men and prostate cancer: a clue"  This reference links to a non-governmental website (last accessed 2/2008)
(Feb 27) Startribune.com reports, "Compared with white men, African American men are 50 percent more likely to develop prostate cancer, and twice as likely to die from it. They also tend to develop it at younger ages."

"Genetics might engineer path to successful aging"  This reference links to a non-governmental website (last accessed 2/2008)
(Feb 27) MedIndia reports, "Rapid advances in using human genes to diagnose, prevent and treat diseases are bringing closer the time when many people can achieve their genetic potential to live 100 years or longer, said Dr. Pascal Goldschmidt, dean of the University of Miami Miller School of Medicine."

“Gene therapy shows promise as treatment for diseased lower limbs at risk for amputation"  This reference links to a non-governmental website
(Feb 27) News-Medical.Net reports, "New research suggests that gene therapy is a safe treatment method to explore in patients whose lower limbs are at risk for amputation because of poor circulation caused by blocked blood vessels."

"Gene Variant Keeps Blood Triglyceride Levels Low"  This reference links to a non-governmental website
(Feb 26) Healthfinder.gov reports, "About 3 percent of Americans of European descent have lucked out, genetically speaking, when it comes to keeping blood fats called triglycerides at bay."

"BU prof studies illness' genetics Physical signs tied to schizophrenia"  This reference links to a non-governmental website
(Feb 26) pressconnects.com reports, "An individual with a poor attention span and the inability to track smoothly moving objects with his eyes is likely to be genetically susceptible to schizophrenia, according to a new study published by Binghamton University Professor Mark F. Lenzenweger."

"Schizophrenia linked to genes"
(Feb 26) Los Angeles Times reports, "Scientists have identified genetic mutations that may predispose people to schizophrenia, a brain disorder with symptoms including delusions."

"Weizmann Institute scientists discover genes that can slow cell division and may fight cancer"  This reference links to a non-governmental website
(Feb 26) EurekAlert! reports, "Cancer cells differ from normal cells in, among other things, the way they divide."

"The Prognostic Role Of A Gene Signature From Tumorigenic Breast-Cancer Cells"  This reference links to a non-governmental website
(Feb 26) Medical News Today reports, "A gene expression profile in human breast tumors correlates with metastasis-free survival and overall survival for several tumor types to include prostate cancer (CaP), according to a report in the January 18, 2007 edition of the New England Journal of Medicine. Dr. Liu and colleagues from the University of Michigan, Stanford University and Oncomed published the work."

"Irregular heartbeat linked to genetic mutation"  This reference links to a non-governmental website
(Feb 26) News-Medical.Net reports, "Every day for 10 years, a seemingly heart-healthy 53-year-old woman experienced rapid and irregular heartbeats."

"2,000 Influenza Virus Genomes Now Completed And Publicly Accessible"  This reference links to a non-governmental website
(Feb 25) mediLexicon reports, "The Influenza Genome Sequencing Project, funded by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), has announced that it has achieved a major milestone."

“Carpal Tunnel Syndrome: Hand Overuse vs. Genetics"  This reference links to a non-governmental website
(Feb 25) About reports, "Carpal tunnel syndrome is a painful progressive condition that occurs when the median nerve, which runs from the forearm into the hand, becomes pressed or squeezed at the wrist."

"Leaders Meet To Discuss Emergency Preparedness For Newborn Screening And Genetic
Services"
  This reference links to a non-governmental website
(Feb 24) Medical News Today reports, "Newborn Screening (NBS) saves lives, but what happens in the case of a natural or manmade disaster?"

"microRNAs undergo molecular editing with significant physiological consequences"  This reference links to a non-governmental website
(Feb 22) News-Medical.Net reports, "Tiny molecules called microRNAs, only 19 to 21 nucleotides in length, are able to effectively silence sometimes large sets of genes."

"MicroRNA helps prevent tumors"  This reference links to a non-governmental website
(Feb 22) EurekAlert! reports, "A microRNA directly regulates a gene implicated in human cancers, researchers from Whitehead Institute and Massachusetts Institute of Technology report in the February 22nd online issue of Science."

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Genomics in Scientific Literature
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Analysis of phenotype-genotype connection: the story of dissecting disease pathogenesis in genomic era in China, and beyond
Shen Y, et al.
Philos Trans R Soc Lond B Biol Sci  2007 Feb

Invited Commentary: Two Studies of Genetic Control of Birth Weight Where Large Data Sets Were Available
Beaty T
Am J Epidemiol 2007 Feb

Genetic and Environmental Influences on Birth Weight, Birth Length, Head Circumference, and Gestational Age by Use of Population-based Parent-Offspring Data
Lunde A, et al.
Am J Epidemiol 2007 Feb

Bioinformatics approaches in the study of cancer
Hanauer DA, et al.
Curr Mol Med 2007 Feb;7(1):133-41

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
Petitjean A, et al.
Hum Mutat 2007 Feb

When You Care Enough to Do Your Very Best: Genetic Counselor Experiences of Compassion Fatigue
Benoit LG, et al.
J Genet Couns 2007 Feb

Clinical Characterization and Risk Profile of Individuals Seeking Genetic Counseling for Hereditary Breast Cancer in Brazil
Palmero EI, et al.
J Genet Couns 2007 Feb

Knowledge and Expectations of Women Undergoing Cancer Genetic Risk Assessment: A Qualitative Analysis of Free-Text Questionnaire Comments
Phelps C, et al.
J Genet Couns 2007 Feb

Exploiting Hardy-Weinberg Equilibrium for Efficient Screening of Single SNP Associations from Case-Control Studies
Chen J & Chatterjee N
Hum Hered 2007 Feb;63(3-4):196-204

Haplotype uncertainty in association studies
Mensah FK, et al.
Genet Epidemiol 2007 Feb

The interaction of host genetic factors and Helicobacter pylori infection
Ando T, et al.
Inflammopharmacology 2007 Feb;15(1):10-4

Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy
Huang Y
Cancer Metastasis Rev 2007 Feb

The human genome and understanding of common disease: present and future technologies
McKinney C & Merriman TR
Cell Mol Life Sci 2007 Feb

A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans
Bond GL & Levine AJ
Oncogene 2007 Feb;26(9):1317-23

Family History
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 In The News

  No articles this week.

 In The Scientific Literature

Family history of cancer and utilization of prostate, colorectal and skin cancer screening tests in U.S. men
Shah M, et al.
Prev Med 2007 Jan

BRCA1 promoter deletions in young women with breast cancer and a strong family history: A population-based study
Smith LD, et al.
Eur J Cancer 2007 Feb

Cancer Family History Reporting: Impact of Method and Psychosocial Factors
Kelly KM, et al.
J Genet Couns 2007 Feb

Genetic Testing
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 In The News

"Genetic testing faces legal obstacles, doctors' limited expertise"  This reference links to a non-governmental website (last accessed 2/2008)
(Feb 27) The Arizona Republic reports, "Genes can be powerful predictors of a person's future health problems, but testing a patient's genes to tailor treatment strategies remains at the cutting edge of health care and legal professions."

"Schanie's test results stir mixed emotions"  This reference links to a non-governmental website
(Feb 26) The Courier-Journal reports, "Genetic testing provided no answers about why Megan Schanie got breast cancer at age 31."

"People With Genetic Predictors Of Colorectal Cancer Are Not Getting Screened - More Likely To Get Tested If Directed To Do So By Their Doctor"  This reference links to a non-governmental website
(Feb 22) Medical News Today reports, "Even when diagnosed with a condition that is a strong genetic predictor of colorectal cancer, many patients do not seek out genetic counseling or cancer screening."


 In The Scientific Literature

Genes and Pulmonary Arterial Hypertension
Sztrymf B, et al.
Respiration 2007;74(2):123-32

Knowledge and Attitudes Towards Genetic Testing: A Two Year Follow-Up Study in Patients with Asthma, Diabetes Mellitus and Cardiovascular Disease
Calsbeek H, et al.
J Genet Couns 2007 Feb

Psychological Follow-up of Presymptomatic Genetic Testing for Spinocerebellar Ataxia Type 2 (SCA2) in Cuba
Paneque M, et al.
J Genet Couns 2007 Feb

Development and Pilot Testing of Two Decision Aids for Individuals Considering Genetic Testing for Cancer Risk
Wakefield CE, et al.
J Genet Couns 2007 Feb

Sharing GJB2/GJB6 Genetic Test Information with Family Members
Blase T, et al.
J Genet Couns 2007 Feb

Managing genetic discrimination: Strategies used by individuals found to have the Huntington disease mutation
Bombard Y, et al.
Clin Genet 2007 Mar;71(3):220-31

Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia
Schirru E, et al.
Eur J Clin Nutr 2007 Feb

Concern, pressure and lack of knowledge affect choice of not wanting to know high-risk status
Swartling U, et al.
Eur J Hum Genet 2007 Feb

The Italian External Quality Control Programme for cystic fibrosis molecular diagnosis: 4 years of activity
Salvatore M, et al.
Clin Chem Lab Med 2007;45(2):254-60

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 28, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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New This Week

Pharmacogenomics This reference links to a non-governmental website (last accessed 2/2008)
October 17-20, 2007 ~ Hinxton, UK

Genomics Disorders 2007 This reference links to a non-governmental website (last accessed 2/2008)
March 21-24, 2007 ~ Hinxton, UK
   
  American Association for Cancer Research Annual Meeting 2007 This reference links to a non-governmental website (last accessed 2/2008)
April 14-18, 2007 ~ Los Angeles, CA
   
New This Week

Genome Informatics This reference links to a non-governmental website (last accessed 2/2008)
November 1-5, 2007 ~ Cold Spring Harbor, New York

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Let's Go Surfing
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Family History and Your Health  This reference links to a non-governmental website you will need a free Acrobat reader to view this file(308KB)
The new issue of the newsletter is available by the Public Health Genomics Program in the Michigan Department of Community Health. This issue highlights sudden cardiac death in the young and American Heart Month.

Genetic Disorders
Medline Plus provides an array of information on latest news, overviews, diagnosis/symptoms, prevention/screening, disease management, specific conditions, etc.

Gene Almanac This reference links to a non-governmental website
This websites provides various links from the Cold Springs Harbor Laboratory Dolan DNA Learning Center which include information on basic heredity, genetic disorders, eugenics, the discovery of the structure of DNA, DNA sequencing, cancer, and plant genetics.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: March 1, 2007 (archived document)
Content Source: National Office of Public Health Genomics