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 Thursday, January 11, 2007     Volume 18   Number 2  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
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A CDC-sponsored evidence report on Testing for CYP450 Polymorphisms in Adults With Non-Psychotic Depression Treated With SSRIs has been released by the Agency for Healthcare Research & Quality (AHRQ).

CDC Announcements
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“New Report Finds Little Evidence To Determine the Usefulness of Genetic Tests in the Treatment of Depression”
(Jan 4) AHRQ reports, “There is insufficient evidence to determine if current gene-based tests intended to personalize the dose of medications in a class of drugs called selective serotonin reuptake inhibitors (SSRIs) improve patient outcomes or aid in treatment decisions in the clinical setting, according to a new evidence report supported by a collaboration of the Agency for Healthcare Research and Quality (AHRQ) and the Centers for Disease Control and Prevention's (CDC) National Office of Public Health Genomics.

   
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NIH Monthly Seminar Series
Public Health Genomics: "Closing the Gap Between Human Genome Discoveries and Population Health"
   
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HuGENet™ What's New
January 2007
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Study examines genetic factors associated with head and neck cancer” This reference links to a non-governmental website
(Jan 9) EurekAlert! reports, “Preliminary research indicates that several specific genetic alterations are associated with the development of smoking-related head and neck skin cancers, according to a report in the January 10 issue of JAMA.”

“Researchers identify gene associated with severe kidney failure in diabetes” This reference links to a non-governmental website
(Jan 9) EurekAlert! reports, “A research team at Wake Forest University Baptist Medical Center and the University of Heidelberg has proven that a gene protects some people with diabetes from developing severe kidney failure or "end-stage renal disease.”

“USC study in Nature Genetics supports a stem cell origin of cancer” This reference links to a non-governmental website
(Jan 8) EurekAlert! reports, “Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development.”

“Researchers Take 'Chips' to the Next Level of Gene Hunting” This reference links to a non-governmental website
(Jan 8) The JHU Gazette reports, “Researchers at the Johns Hopkins High Throughput Biology Center have invented two new gene "chip" technologies that can be used to help identify otherwise elusive disease-causing mutations in the 97 percent of the genome long believed to be "junk."”

“Japan scientists link strokes to gene variant” This reference links to a non-governmental website
(Jan 8) AlertNet reports, “Japanese researchers have identified a gene variant which appears to predispose a person to strokes, but it seems more prevalent in Asians than in those of European or African descent.”

“Scientists Find Guardian Gene's Choices Crucial To Stopping Cancer Process” This reference links to a non-governmental website
(Jan 8) Science Daily reports, “Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have uncovered a novel pathway by which the anti-cancer gene p53 springs into action, protecting a damaged cell from becoming cancer.”

“Genes, lifestyle raise macular degeneration risk” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 10) Optimist reports, “New research suggests that one's genetic make-up interacts with two modifiable risk factors -- obesity and smoking -- to multiply the risk of developing age-related macular degeneration (AMD), a potentially blinding degenerative eye disorder.”

“Genetically altered cells may help artificial skin fight infection” This reference links to a non-governmental website
(Jan 8) EurekAlert! reports, “Cincinnati burn researchers have created genetically modified skin cells that, when added to cultured skin substitutes, may help fight off potentially lethal infections in patients with severe burns.”

“Chaos In The Cell Defect Gene Disrupts Signal Processing Within The Cell And Damages The Immune System” This reference links to a non-governmental website
(Jan 8) Medical News Today reports, “Researchers from the Innsbruck Biocenter and the Hannover Medical School in cooperation with the University of Freiburg have discovered a genetic cause of disrupted signal transduction in cells.”

“Genetic expression speaks as loudly as gene type” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 7) news@nature.com reports, “Some ethnic differences could be down to the same genes behaving differently.”

“Researchers Looking For Genes That Control The Brain” This reference links to a non-governmental website
(Jan 7) Medical News Today reports, “Although it’s our most vital organ, surprisingly little is known about what constitutes a "normal" brain.”

“Jefferson scientists find guardian gene's choices crucial to stopping cancer process” This reference links to a non-governmental website
(Jan 5) EurekAlert! reports, “Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have uncovered a novel pathway by which the anti-cancer gene p53 springs into action, protecting a damaged cell from becoming cancer.”

“Rogue Gene Linked To Breast And Childhood Cancer Risk” This reference links to a non-governmental website
(Jan 5) Medical News Today reports, “Women who inherit one damaged copy of a gene called PALB2 have double the risk of developing breast cancer.”

“Genetic Mutation Alters Response To Heart Failure Drugs” This reference links to a non-governmental website
(Jan 5) Science Daily reports, “The group of drugs known as beta blockers help slow nerve impulses traveling through the heart in order to reduce the heart's workload.”

“G Allele Of Mu-opioid Receptor Gene Is Linked To Craving For Alcohol” This reference links to a non-governmental website
(Jan 5) Science Daily reports, “The study of genes and their influence on alcohol consumption can operate on many different levels.”

“Gender affects genes' influence on blood pressure” This reference links to a non-governmental website  (last accessed 3/2007)
(Jan 4) USPharMD reports, “Variations in genes that play a role in regulating heart rate and kidney function appear to affect blood pressure differently in men and women, new research suggests.”

“MGH Cancer Center researchers find new gene associated with Wilms tumor” This reference links to a non-governmental website
(Jan 4) EurekAlert! reports, “Researchers at the Massachusetts General Hospital (MGH) Cancer Center have discovered a novel gene mutation associated with Wilms tumor, the most common pediatric kidney cancer.”

“Renegade RNA -- Clues to cancer and normal growth” This reference links to a non-governmental website
(Jan 4) EurekAlert! reports, “Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code.”

“British gene team are on the brink of cancer breakthrough” This reference links to a non-governmental website
(Jan 4) The Mail reports, “British scientists are on the verge of producing a drug that could revolutionise cancer treatment.”    

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Genomics in Scientific Literature
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Genetic influences on preterm birth
Defranco E, et al.
Semin Reprod Med 2007 Jan;25(1):40-51

NOD2/CARD15 disease associations other than Crohn's disease
Henckaerts L & Vermeire S
Inflamm Bowel Dis 2006 Dec

Pharmacogenetics of cytochromes P450 in tropical medicine
Ribeiro V & Cavaco I
Curr Drug Targets 2006 Dec;7(12):1709-19

Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?
Pereira TV, et al.
Eur J Epidemiol 2007 Jan

Genomics basics: DNA structure, gene expression, cloning, genetic mapping, and molecular
tests

Tefferi A
Semin Cardiothorac Vasc Anesth 2006 Dec;10(4):282-90

Sudden cardiac death in the young: a clinical genetic approach
Ingles J & Semsarian C
Intern Med J 2007 Jan;37(1):32-7

Genetics of sarcoidosis: candidate genes and genome scans
Iannuzzi MC & Rybicki BA
Proc Am Thorac Soc 2007;4(1):108-16

African americans with asthma: genetic insights
Barnes KC, et al.
Proc Am Thorac Soc 2007;4(1):58-68

Strategies for identifying modifier genes in cystic fibrosis
Boyle MP
Proc Am Thorac Soc 2007;4(1):52-7

Gene-environment interactions in asthma: with apologies to william of ockham
Martinez FD
Proc Am Thorac Soc 2007;4(1):26-31

Haplotype thinking in lung disease
Silverman EK
Proc Am Thorac Soc 2007;4(1):4-8

HMDB: the Human Metabolome Database
Wishart DS, et al.
Nucleic Acids Res 2007 Jan;35(Database issue):D521-6

Family History
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“Genetic variation may reduce Alzheimer's risk” This reference links to a non-governmental website
(Jan 8) EurekAlert! reports, “Adults with a genetic variation enabling them to express higher levels of fetal hemoglobin may have a reduced risk of Alzheimer's disease, researchers say.”

“January Is National Birth Defects Prevention Month And Family Health History Month” This reference links to a non-governmental website
(Jan 4) Michigan.gov reports, “The Michigan Department of Community Health (MDCH) is pleased to recognize January 2007 as a special time to both reduce the risk of birth defects and increase awareness of the role of family history to health and risk for disease.”  (Find more information at Michigan’s Genetics Resource Center). This reference links to a non-governmental website

Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer
Niessen RC, et al.
Gut 2006 Dec;55(12):1781-8

Family history of cancer provided by hospital controls was satisfactorily reliable
Bravi F, et al.
J Clin Epidemiol 2007 Feb;60(2):171-5

Increased heritability of certain types of anorectal malformations
Falcone RA Jr, et al.
J Pediatr Surg 2007 Jan;42(1):124-7; discussion 127-8

In search of a familial cancer risk assessment tool
Kelly K & Sweet K
Clin Genet 2007 Jan;71(1):76-83

Genetic Testing
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“People at genetic risk for Alzheimer's age mentally just like noncarriers” This reference links to a non-governmental website
(Jan 8) EurekAlert! reports, “Australian researchers say that a genotype that heightens the risk for Alzheimer's disease does not contribute to cognitive change during most of adulthood.”

“Analysis: Gene Tests Put Docs at Risk” This reference links to a non-governmental website
(Jan 6) Red Orbit reports, “The growth of personalized medicine -- treatment designed specifically for the genetic makeup of an individual -- could lead to a flood of new medical malpractice lawsuits, says a new report.”

“Gene test devised to predict lung cancer relapse risk”  
(Jan 4) Yahoo! India reports, “A new gene test can predict how people with lung cancer will fare, say researchers, allowing aggressive chemotherapy to be targeted to only those who need it.”

Outcome of neonatal screening for medium-chain acyl-CoA dehydrogenase deficiency in Australia: a cohort study
Wilcken B, et al.
Lancet 2007 Jan;369(9555):37-42

Family system characteristics and psychological adjustment to cancer susceptibility genetic testing: a prospective study
van Oostrom I, et al.
Clin Genet 2007 Jan;71(1):35-42

Hereditary hemochromatosis screening: effect of mutation penetrance and prevalence on cost-effectiveness of testing algorithms
Gagne G, et al.
Clin Genet 2007 Jan;71(1):46-58

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 10, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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How do we assess the contribution of complex genotypes and gene-environment interaction to the population burden of common diseases?
February 15, 2007 ~ Rockville, MD (ENVISION - Atlanta, GA)
New This Week Quantitative Genetics And Genomics This reference links to a non-governmental website
February 18-23, 2007 ~ Ventura, CA
   
New This Week Toxicogenomics This reference links to a non-governmental website
June 24-29, 2007 ~ New London, NH
   
New This Week Genetic Toxicology This reference links to a non-governmental website
July 29 – August 3, 2007 ~ Oxford, UK
   
New This Week Structural, Functional & Evolutionary Genomics This reference links to a non-governmental website
July 29 – August 3, 2007 ~ Cambridge, UK
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Let's Go Surfing
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What would you do if it became possible to sequence the equivalent of a full human genome for only $1,000?  This reference links to a non-governmental website
Question of the Year (From Nature Genetics)

Genetics and Genomics for Patients and the Public
From the National Human Genome Research Institute

PDGene- Published PR Candidate Genes This reference links to a non-governmental website
The PDGene database aims to provide an unbiased, centralized, publicly available and regularly updated collection of genetic association studies performed on PD phenotypes.

Race and Human Variation This reference links to a non-governmental website
A project of the American Anthropological Association: Looking through the eyes of history, science and lived experience, the RACE Project explains differences among people and reveals the reality – and unreality – of race.  The story of race is complex and may challenge how we think about race and human variation, about the differences and similarities among people.


 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: January 11, 2007 (archived document)
Content Source: National Office of Public Health Genomics