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 Thursday, Sept. 28, 2006     Volume 17   Number 13  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
Spotlight
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September is National Cholesterol Month
High blood cholesterol is a major risk factor for heart disease, the leading cause of death in the United States. Lowering cholesterol levels can reduce the risk of heart disease death among persons either with or without coronary heart disease. Also, individuals from families with a strong history of early heart attacks should be

evaluated with a lipid screen. They may have Familial Hypercholesterolemia (FH) which affects 1 in 500 people in the US. For more infromation on FH, consult Medline Plus resources. Also consult CDC Family History resources.

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CDC Announcements
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Genomics, epidemiology, and common complex diseases: let's not throw out the baby with the bathwater! You will need a free Acrobat player to view this file(39 KB)
Muin J. Khoury and Marta Gwinn
International Journal of Epidemiology (September 2006)
   
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Population-based study of the prevalence of family history of cancer: Implications for cancer screening and prevention
Scott D. Ramsey et al.
Genet Med. 2006 Sep;8(9):571-575

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Dislike of veggies is in the genes” This reference links to a non-governmental website (last accessed 2/2008)
(Sep 26) foodproductdaily.com reports, “The reason why some people dislike vegetables such a broccoli and sprouts is due to the genetic defence mechanism to potentially harmful compounds in the plants, a result that deepens our understanding of taste.”

“In-depth Analysis Of Human Genetic Variation Will Enable Scientists To Identify Genetic Risk Factors For Common Immune Diseases” This reference links to a non-governmental website
(Sep 28) Medical News Today reports, “An international group of researchers today unveiled a detailed map of human genetic variation within the major histocompatibility complex (MHC), the most important region of the human genome encoding the human response to infection, autoimmune disease and organ transplantation.”

“‘Angel and devil’ genes hold the key to treatment for MS”
(Sep 28) The Herald reports, “Multiple Sclerosis symptoms can be affected by a pair of "angel and devil" genes that fight to make a patient healthy or ill, researchers have found.”

“Genetic basis for 'pulling your hair out' revealed” This reference links to a non-governmental website
(Sep 27) netdoctor.co.uk reports, “Scientists believe they have identified the genetic mutations that lead people to suffer from a condition that causes them to compulsively pull their hair.”

“Researchers map genetic variations behind common immune diseases”
(Sep 26) Yahoo News India reports, “An international group of researchers have unveiled a detailed map of human genetic variations within one of the most important regions of the human genome called histocompatibility complex (MHC), which is responsible for encoding the human response to infections.”

“New Findings Back Eczema Gene Link” This reference links to a non-governmental website
(Sep 26) Science Daily reports, “The results of twenty studies that strongly back up a genetic breakthrough made by a University of Dundee scientist were announced recently.”

“Study shows how gene creates "morning larks"”
(Sep 26) iol reports, “Scientists are closer to understanding how a particular gene mutation causes some people to be extreme morning larks -- findings that could eventually aid in understanding various sleep disorders.”

“Researchers Locate Genetic Link for Nicotine Dependence Among African Americans” This reference links to a non-governmental website
(Sep 25) Medindia.com reports, “Scientists at the University of Virginia Health System have identified, for the first time ever, several genetic regions that are likely to carry the genes for nicotine dependence (ND) in an African American population.”

“Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic
system”
This reference links to a non-governmental website
(Sep 25) News-Medical.Net reports, “There seems to be little doubt among cancer researchers that new detection systems using nanowires and microfluidics hold the promise of providing a quantum leap in the detection of cancer-related molecules and genes.”

“Varanasi to Host Historic Genetic Disorder Symposium” This reference links to a non-governmental website
(Sep 25) India West reports, “Indian and U.S. researchers on thalassemia and other genetic blood disorders will gather together at an historic symposium in Varanasi Oct. 29-31.”

“Genetics forum aims to engage public”
(Sep 22) The News & Observer reports, “When scientists speak about genetics research, they often gush about its promise to battle disease and prevent illness.”

“Researchers get $100m to study cancer genetics” This reference links to a non-governmental website
(Sep 22) Boston.com reports, “A New York philanthropy is giving $100 million to the Broad Institute of the Massachusetts Institute of Technology and Harvard and four New York research centers to study the genetics of cancer, part of the push to transform the treatment of the disease by understanding its genetic makeup.”

“Direct observations of DNA provides new insights into how genetic material is copied and
repaired”
This reference links to a non-governmental website
(Sep 21) News-Medical.Net reports, “Direct observations of DNA are giving new insights into how genetic material is copied and repaired.”

“New target for cancer therapy identified by Australian researchers”  This reference links to a non-governmental website
(Sep 21) News-Medical.Net reports, “A new target for cancer therapy has been identified by Monash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer development.”

“Doctor a researcher and a caregiver, too”
(Sep 21) Baltimoresun.com reports, “A lot of prominent scientists have dreamed of using the genetics revolution to cure or prevent disease. Few have done as much to make that dream a reality as has a gray-haired 55-year-old pediatrician in Strasburg, Pa.”

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Genomics in Scientific Literature
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Inflammatory Bowel Disease Genetics: Nod2
Cho JH & Abraham C
Annu Rev Med 2006 Sep

Parkinson's disease and genetics
Lester J & Otero-Siliceo E
Neurologist 2006 Sep;12(5):240-4

The genetics of FAP and FAP-like syndromes
Lipton L & Tomlinson I
Fam Cancer 2006;5(3):221-6

Confirming a diagnosis of hereditary colorectal cancer: the impact of a Familial Bowel Cancer Registry in New Zealand
James P, et al.
N Z Med J 2006;119(1242):U2168

Pharmacogenetics and tailored drug treatment in schizophrenia
Andreassen OA & Steen VM
Tidsskr Nor Laegeforen 2006 Sep;126(18):2400-2

Modifiers of risk of hereditary breast cancer
Narod SA
Oncogene 2006 Sep;25(43):5832-6

Clinical management of BRCA1 and BRCA2 mutation carriers
Domchek SM & Weber BL
Oncogene 2006 Sep;25(43):5825-31

Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features
Filipe-Santos O, et al.
Semin Immunol 2006 Sep

Role of host genes in sporadic gastric cancer
El-Omar EM
Best Pract Res Clin Gastroenterol 2006 Aug;20(4):675-86

Recent Advances in the Genetics of Autism
Gupta AR & State MW
Biol Psychiatry 2006 Sep

Familial neuroendocrine tumor syndromes: From genetics to clinical practice
Sakurai A, et al.
Pituitary 2006 Sep

An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment
Contopoulos-Ioannidis DG, et al.
Pharmacogenet Genomics 2006 Oct;16(10):705-11

Pharmacogenetics of HIV therapy
Owen A, et al.
Pharmacogenet Genomics 2006 Oct;16(10):693-703

Incidental Carcinomas in Prophylactic Specimens in BRCA1 and BRCA2 Germ-line Mutation Carriers, With Emphasis on Fallopian Tube Lesions: Report of 6 Cases and Review of the Literature
Carcangiu ML, et al.
Am J Surg Pathol 2006 Oct;30(10):1222-30

Type-2 diabetes: a cocktail of genetic discovery
Freeman H & Cox RD
Hum Mol Genet 2006 Oct;15 Suppl 2:R202-9

Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease
Talbot K & Ansorge O
Hum Mol Genet 2006 Oct;15 Suppl 2:R182-7

Genetics of obesity and the prediction of risk for health
Walley AJ, et al.
Hum Mol Genet 2006 Oct;15 Suppl 2:R124-30

Genetic susceptibility to myocardial infarction and coronary artery disease
Topol EJ, et al.
Hum Mol Genet 2006 Oct;15 Suppl 2:R117-23

The genetics of mental retardation
Raymond FL & Tarpey P
Hum Mol Genet 2006 Oct;15 Suppl 2:R110-6

Influence of genetic and environmental factors on lipid metabolism and cardiovascular risk associated with the apoE gene
Antonio Moreno J, et al.
Med Clin (Barc) 2006 Sep;127(9):343-51

Quantifying the amount of missing information in genetic association studies
Nicolae DL
Genet Epidemiol 2006 Sep

Imputation methods to improve inference in SNP association studies
Dai JY, et al.
Genet Epidemiol 2006 Sep

Testing Untyped Alleles (TUNA)-applications to genome-wide association studies
Nicolae DL
Genet Epidemiol 2006 Sep

Family History
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“Web tool helps gauge risk of having genetic mutation linked to colon cancer” This reference links to a non-governmental website
(Sep 26) EurekAlert! reports, “Researchers at Brigham and Women's Hospital and Dana-Faber Cancer Institute have developed an online questionnaire to help physicians determine whether patients at risk for colon cancer are likely to carry mutations in two genes linked to the most common hereditary form of the disease.”

“Tracking a genetic killer in the family” This reference links to a non-governmental website
(Sep 23) ContraCostaTimes.com reports, “Survivors of rare cancer and their relatives try to help doctors unravel medical mystery before it strikes the next generation.”

Cancer incidence in first-degree relatives of a population-based set of cases of early-onset breast cancer
Rawal R, et al.
Eur J Cancer 2006 Sep

Family History and the Risk of Sudden Cardiac Death as a Manifestation of an Acute Coronary Event
Kaikkonen KS, et al.
Circulation 2006 Sep

Family history and inherited thrombophilia
VAN Sluis GL, et al.
J Thromb Haemost 2006 Oct;4(10):2182-7

Healthy women with a family history of breast cancer: impact of a tailored genetic counseling intervention on risk perception, knowledge, and menopausal therapy decision making
Matloff ET, et al.
J Womens Health (Larchmt) 2006 Sep;15(7):843-56

Genetic Testing
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“Gene therapy study takes aim at prostate cancer” This reference links to a non-governmental website
(Sep 25) EurekAlert! reports, “Researchers at Baylor College of Medicine (BCM) are hoping a new gene therapy that takes a gene called RTVP-1 directly into the prostate tumor will prove effective in preventing recurrence of the disease.”

Genetic screening by DNA technology: a systematic review of health economic evidence
Rogowski W
Int J Technol Assess Health Care 2006 Summer;22(3):327-37

Economics of tandem mass spectrometry screening of neonatal inherited disorders
Pandor A, et al.
Int J Technol Assess Health Care 2006 Summer;22(3):321-6

Familial adenomatous polyposis: the practical applications of clinical and molecular screening
Rozen P & Macrae F
Fam Cancer 2006;5(3):227-35

CDC sponsored material Predictive genetic testing for type 2 diabetes
Janssens AC, et al.
BMJ 2006 Sep;333(7567):509-10

Using the impact of event scale to evaluate distress in the context of genetic testing for breast cancer susceptibility
Dorval M, et al.
Psychol Rep 2006 Jun;98(3):873-81

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 27, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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International Society of Nurses in Genetics (ISONG) 19th Annual Conference This reference links to a non-governmental website
October 7-10, 2006 ~ New Orleans, LA

 

9th Annual Computational Genomics Conference This reference links to a non-governmental website
October 28-31, 2006 ~ Baltimore, MD

   
New This Week International Symposium on New Frontiers in Tuberculosis Research
December 4-6, 2006 ~ New Delhi, India
   
New This Week The Fifth Asia Pacific Bioinformatics Conference This reference links to a non-governmental website
January 15-17, 2007 ~ Hong Kong
   
New This Week RNAi World Congress This reference links to a non-governmental website
April 24-25, 2007 ~ Philadelphia, PA
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Let's Go Surfing
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Secretary' s Advisory Committee on Heritable Disorders and Genetic Diseases in Newborns and Children
The committee advises the Secretary regarding the most appropriate application of universal newborn screening tests, technologies, and programs for reducing morbidity and mortality of children with heritable disorders.

Single Gene Disorders and Disability (SGDD)
CDC program on Single Gene Disorders and Disability (SGDD): Aims to enhance the health and well-being of people who have disabling or potentially disabling single gene disorders and their families by promoting the best medical, functional and psychosocial outcomes

National Coordinating Center for the Genetics and Newborn Screening Regional Collaborative
Groups
This reference links to a non-governmental website
The NCC is formed as a partnership with HRSA through a cooperative agreement with the American College of Medical Genetics (ACMG) as part of on-going efforts to improve the health of children and their families by promoting the translation of genetic medicine into public health and health care services.

American Academy of Pediatrics Newborn Screening Fact Sheets (2006) You will need a free Acrobat player to view this file(413KB)

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: September 28, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics