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 Thursday, Nov. 2, 2006     Volume 17   Number 18  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
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A CDC-sponsored evidence report on Genomic Tests for Ovarian Cancer Detection and Management has been released by the Agency for Healthcare Research and Quality (AHRQ).

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CDC Announcements
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New HuGE Review
Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and
Psychiatric Disorders: A HuGE Review
 you will need a free Acrobat reader to view this file(154KB)
Simon Gilbody, et al.
Am J Epidemiol 2006 Oct 30
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New HuGE Review
Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer you will need a free Acrobat reader to view this file(164KB)
Valentina Paracchini, et al.
Am J Epidemiol 2006 Oct 19
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Jefferson scientists show gene reverts cancer genes to normal, predicts breast cancer
prognosis”
 This reference links to a non-governmental website
(Oct 31) EurekAlert! reports, “Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer.”

“Three new lung tumor subtypes identified in DNA profiling study”  This reference links to a non-governmental website
(Nov 1) innovations report reports, “A new study has identified three subtypes of non-small-cell lung cancer tumors, a finding that may provide valuable clinical information about patient survival in early- or late-stage disease, how likely the cancer is to spread and whether the tumor will prove resistant to chemotherapy.”

“Genetic 'link' to cot deaths”  This reference links to a non-governmental website
(Nov 1) Daily Mail reports, “Scientists in the US say they have found the strongest evidence yet that cot death is caused partly by a genetic disorder, which may one day be treatable.”

“Viral Genetics' AIDS Study Results to Be Presented at Institute of Human Virology's 2006 International Meeting”  This reference links to a non-governmental website
(Oct 31) Medical News Today reports, “The results of Viral Genetics' (OTC Bulletin Board: VRAL - News) recent AIDS study of VGV-1 in South Africa will be presented at the Institute of Human Virology's (IHV) 2006 Annual International Meeting on November 17 in Baltimore, Maryland.”

“Gene Therapy Appears To Reduce Symptoms Of Parkinson's By 40 Percent”  This reference links to a non-governmental website
(Oct 30) Science Daily reports, “Ceregene, Inc., has announced that CERE-120, a gene therapy product in development for the treatment of Parkinson’s disease, was well tolerated and appeared to reduce symptoms by approximately 40% (p<0.001), as measured by the Unified Parkinson’s Disease Rating Scale (UPDRS) motor “off” score, in an open-label Phase 1 study in 12 patients with advanced disease.”

“Genetic 'breakthough' offers hope to schizophrenia victims”  This reference links to a non-governmental website
(Oct 30) Guardian Unlimited reports, “Scientists have discovered a variation in a gene in people at risk of schizophrenia that strongly suggests they will develop the condition.”

“454 Sequencing™ Reveals New Pathway In RNA Interference”  This reference links to a non-governmental website
(Oct 30) Medical News Today reports, “CuraGen Corporation's majority-owned subsidiary 454 Life Sciences today announced that research on small RNAs, conducted by Cold Spring Harbor Laboratory, has revealed the dual role of the ARGONAUTE 4 protein (AGO4) in RNA-directed DNA methylation.”

“Finding Genomic Elements involved in Human Disease with a New Approach”  This reference links to a non-governmental website
(Oct 29) www.uni-protokolle.de reports, “With their new approach, the bioformatics expert and systems biologist Professor Nikolaus Rajewsky from the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Dr. Kevin Chen from the Center for Comparative Functional Genomics, New York University, New York (USA) are now able to look more systematically for structures in the human genome which are likely to be deleterious and are the causes of human disease.”

“Towards a Global Map of Epigenetic Variation”  This reference links to a non-governmental website
(Oct 29) UK Bioinformatics Forum reports, “A new DNA map, published in Nature Genetics today, provides the first large-scale study of biological inheritance in human that is not DNA-sequence based.”

“Experts crack cancer 'gene codes'”  This reference links to a non-governmental website
(Oct 28) BBC News reports, “US scientists have cracked the entire genetic code of breast and colon cancers, offering new treatment hopes.”

“Let's Divide: How Daughter Cells Get Their Share Of Genetic Material”  This reference links to a non-governmental website
(Oct 28) Science Daily reports, “When cells divide, control mechanisms ensure that the genetic material, in other words the chromosomes, is correctly distributed to the daughter cells.”

“International Conference on Tularemia to be held in Woods Hole”  This reference links to a non-governmental website
(Oct 27) EurekAlert! reports, “Scientists who study the bacterium Francisella tularensis, and the illness it causes, tularemia, will be meeting next week at the MBL (Marine Biological Laboratory) for the Fifth International Conference on Tularemia.”

“Gene Could Point to Crohn's, Colitis Treatments”   This reference links to a non-governmental website (last accessed 2/2008)
(Oct 26) Hon News reports, “A newly discovered gene may help protect carriers against Crohn's disease and colitis, inflammatory bowel diseases (IBDs) that affect an estimated one million Americans, researchers say.”

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Genomics in Scientific Literature
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Human Susceptibility to Viral Infection: The Search for HIV-Protective Alleles among Africans by Means of Genome-Wide Studies
Donfack J, et al.
AIDS Res Hum Retroviruses 2006 Oct;22(10):925-30

Gene polymorphisms leading to calcified and stenotic aortic valves
Anger T, et al.
Herz 2006 Oct;31(7):635-43

High-Throughput Single-Nucleotide Polymorphisms Genotyping: TaqMan Assay and Pyrosequencing Assay
Shen GQ, et al.
Methods Mol Med 2006;128:209-24

Screening for fragile X syndrome: international experiences
Vuust J, et al.
Ugeskr Laeger 2006 Oct;168(43):3704-9

Genetic counselors and research: Current practices and future directions
Clark HM, et al.
Am J Med Genet C Semin Med Genet 2006 Oct;142C(4):276-83

Uncertainty and perceived personal control among parents of children with rare chromosome conditions: The role of genetic counseling
Lipinski SE, et al.
Am J Med Genet C Semin Med Genet 2006 Oct;142C(4):232-40

Referral to cancer genetic counseling: Are there stages of readiness?
O'neill SM, et al.
Am J Med Genet C Semin Med Genet 2006 Oct;142C(4):221-31

Genetics of Parkinson's disease and parkinsonism
Hardy J, et al.
Ann Neurol 2006 Oct;60(4):389-98

Computation of haplotypes on SNPs subsets: advantage of the "global method"
Coulonges C, et al.
BMC Genet 2006 Oct;7(1):50

Pharmacogenomics: A reality or still a promise?
Bepler G
Lung Cancer 2006 Oct

Genetics of psoriasis
Jullien D & Barker J
J Eur Acad Dermatol Venereol 2006 Nov;20(s2):42-51

The routinisation of genomics and genetics: implications for ethical practices
Foster MW, et al.
J Med Ethics 2006 Nov;32(11):635-8

Genetics of Dopamine and its Contribution to Cocaine Addiction
Haile CN, et al.
Behav Genet 2006 Oct

Family History
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“Family cancer risk 'without gene'”  This reference links to a non-governmental website
(Oct 31) BBC News reports, “Women with a family history of breast cancer have a greater chance of getting the disease even without inheriting the "high risk" genes, scientists say.”

Risk factors for breast carcinoma in situ versus invasive breast cancer in a prospective study of pre- and post-menopausal women
Reinier KS, et al.
Breast Cancer Res Treat 2006 Oct

Association between first-degree familial predisposition of asthma and atopy (total IgE) in newborns
Kuiper S, et al.
Clin Exp Allergy 2006 May;36(5):594-601

Impact of a Family History of Colorectal Cancer on the Prevalence of Advanced Adenomas of the Rectosigmoid Colon at Flexible Sigmoidoscopy in 3147 Asymptomatic Patients
Strum WB
Dig Dis Sci 2006 Oct

Metabolic syndrome in nondiabetic, obese, first-degree relatives of African American patients with type 2 diabetes: African American triglycerides-HDL-C and insulin resistance paradox
Meis SB, et al.
Ethn Dis 2006 Autumn;16(4):830-6

Genetic Testing
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“Genzyme Launches New Cystic Fibrosis Gene Sequencing Test”  This reference links to a non-governmental website
(Nov ) Medical News Today reports, “Genzyme Corporation announced today the commercial availability of cystic fibrosis (CF) gene sequencing, a new diagnostic test that can detect approximately 98 percent of the more than 1,200 disease-causing mutations in the CFTR gene.”

“Lung tumor test is big step”  This reference links to a non-governmental website (last accesssed 2/2008)
(Oct 31) The News & Observer reports, “Physicians at UNC-Chapel Hill have helped develop a genetic test that could one day provide lung cancer patients and their doctors with specific information about lung tumors, including whether the tumors will respond to certain treatments.”

“Genetic variation renders tamoxifen useless for some”  This reference links to a non-governmental website
(Oct 30) cancerfacts.com reports, “Up to 10 percent of women taking tamoxifen to prevent recurrence of their breast cancer gain no protection from the drug, and an FDA panel is recommending that the drug label be changed to inform women about that.”

“Analysis of breast-cancer gene role offers promising target”
(Oct 30) EurekAlert! reports, “Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.”

“Fair offers tests to reveal genetic disease carriers”  This reference links to a non-governmental website
(Oct 26) PalmBeachPost.com reports, “When Lois Siegel of Boynton Beach was pregnant more than three decades ago, she had no idea she was a carrier of Tay-Sachs disease.”

Morphology of Breast Cancer as a Means of Triage of Patients for BRCA1 Genetic Testing
Farshid G, et al.
Am J Surg Pathol 2006 Nov;30(11):1357-66

Uncertainty in BRCA1 cancer susceptibility testing
Baty BJ, et al.
Am J Med Genet C Semin Med Genet 2006 Oct;142C(4):241-50

Ethical and clinical practice considerations for genetic counselors related to direct-to-consumer marketing of genetic tests
Wade CH & Wilfond BS
Am J Med Genet C Semin Med Genet 2006 Oct;142C(4):284-92

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending November 1, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Secretary’s Advisory Committee on Genetics, Health, and Society’s Eleventh Meeting
November 13-14, 2006 ~ Adelphi, MD
 

Genomics Momentum 2006  This reference links to a non-governmental website
November 9, 2006 ~ Rotterdam, Netherlands

   
  Annual Scientific Meeting of the International Genetic Epidemiology Society (IGES)  This reference links to a non-governmental website
November 16-17, 2006 ~ St. Pete’s Beach, FL
   
New This Week The 8th International Congress on SLE  This reference links to a non-governmental website
May 23-27, 2007 ~ Shanghai, China
   
New This Week One Origin, One Race, One Earth: Genetics, Human Rights and the Next Phase of Human
Evolution
   This reference links to a non-governmental website
November 15-17, 2007 ~ Calgary, Canada
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Let's Go Surfing
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Inside Cancer  This reference links to a non-governmental website
A Multimedia Guide to Cancer Biology

Genomics & Genetics at the Sanger Institute  This reference links to a non-governmental website
Genomics & Genetics Resources from the welcome Trust Sanger Institute

DNA from the Beginning  This reference links to a non-governmental website
An animated primer on the basics of DNA, genes and heredity including photos, video and audio links, biographies, tasks and links


 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: November 2, 2006 (archived document)
Page last updated: November 6, 2007
Content Source: National Office of Public Health Genomics