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 Thursday, July 13, 2006     Volume 17   Number 2  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Genetic testing for susceptibility to breast and ovarian cancer: Evaluating the impact of a direct-to-consumer marketing campaign on physicians’ knowledge and practices (2006)
Melanie F. Myers, et al.
Genetics in Medicine;8(6):361-370.

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CDC Announcements
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CDC sponsored material

Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

   
CDC sponsored material Storage and use of residual dried blood spots from state newborn screening programs
Olney RS, et al.
J Pediatr 2006 May;148(5):618-22
   
CDC sponsored material

New HuGE Case Studies

CDC sponsored material HuGE What's New
July 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“NIH-Funded Study Seeks Long-lived Families to Help Discover Secrets of Long and Healthy Life” This reference links to a non-governmental website
(July 11) National Institute on Aging reports, “Long, healthy life tends to run in some families, and researchers on a project supported by the National Institutes of Health (NIH) want to learn more about the factors that contribute to it.”

“Gene tests as potential guides for treatments” This reference links to a non-governmental website
(July 12) International Herald Tribune reports, “A decade or so ago, when the revolution in genetics was getting under way, the air was heady with promises.”

“Routine ECGs for newborns would identify life-threatening heart condition” This reference links to a non-governmental website
(July 12) EurekAlert! reports, “Italian heart specialists are calling on health care providers throughout Europe to give urgent consideration to introducing ECG screening for all babies at around three to four weeks of age to pick up a life-threatening genetic condition called long QT syndrome.”

“Women with mutations in BRCA1 or BRCA2 genes can reduce cancer risk by having ovaries
removed”
 This reference links to a non-governmental website
(July 12) News-Medical.Net reports, “Women with mutations in the BRCA1 or BRCA2 genes can significantly reduce their risk of certain types of cancer by having their ovaries removed, according to a study in the July 12 issue of Journal of the American Medical Association.”

“South has 'key role' studying genetic links to disease” This reference links to a non-governmental website
(July 11) SciDev.Net reports, “Researchers in developing nations are at the forefront of global efforts to develop a database of information about how human genetics influences disease.”

“Imaging technology points to small molecules that can fight treatment-resistant tumors” This reference links to a non-governmental website
(July 11) EurekAlert! reports, “Using a newly developed drug screen, researchers at the University of Pennsylvania School of Medicine have discovered small molecule compounds that are able to perform the functions of a gene commonly mutated in many types of cancer.”

“Does My Diet Fit My Genes?” This reference links to a non-governmental website
(July 11) Time reports, “The new science of nutrigenomics has some answers.”

“States Doubled Number of Newborns Tested for Genetic Diseases” This reference links to a non-governmental website
(July 11) Fox News.com reports, “States have nearly doubled the number of newborns being tested for a host of rare but devastating genetic diseases -- yet where you live still determines just how protected your baby will be, the March of Dimes reports.”

“Genetic variation found that predicts response to heart failure medication” This reference links to a non-governmental website
(July 10) EurekAlert! reports, “Researchers at the University of Maryland School of Medicine in Baltimore and the University of Colorado School of Medicine in Denver have identified a common genetic variation that could help determine whether a person with heart failure would benefit from beta-blockers, a class of drugs used to treat chronic heart failure.”
 
“Ensuring That Genetic Testing From Different Laboratories Yields the Same Results” This reference links to a non-governmental website
(July 10) Innovations Report reports, “For individuals who develop colorectal cancers at a young age or have a family history of such cancers, microsatellite instability testing (MSI) has become an almost standard component of clinical evaluation.”

“Women with damaged ATM gene more likely to develop cancer” This reference links to a non-governmental website
(July 10) Guardian Unlimited reports, “Women who inherit a damaged version of a particular gene are more than twice as likely to develop breast cancer, according to research published today.”

“The inability to recognize faces can be inherited” This reference links to a non-governmental website
(July 9) News-Medical.Net reports, “In the first study to examine whether the inability to recognize faces can be inherited, researchers found that it is in fact a common disorder that runs in families and is one of the most frequent disorders apparently controlled by a defect in a single gene.”

“Cell survival depends on chromosome integrity” This reference links to a non-governmental website
(July 9) News-Medical.Net reports, “UCLA researchers report that thousands of genes behave differently in the same organs of males and females - something never detected to this degree.”

“College Urges Reexamination of Gene Patenting and Licensing” This reference links to a non-governmental website
(July 6) College of American Pathologists reports, “CAP President Thomas M. Sodeman, MD, FCAP, testified June 27 on behalf of the College before the U.S. House Subcommittee on Criminal Justice, Drug Policy and Human Resources regarding the Government Accountability Office (GAO) report, Clinical Lab Quality, CMS and Survey Organization Oversight Should Be Strengthened.”

“Gene Mutations Don't Add To The Risk Of Blood Clots In Women Taking Tamoxifen” This reference links to a non-governmental website
(July 6) Medical News Today reports, “Two genetic mutations may not increase the risk of blood clots in women taking tamoxifen for breast cancer prevention.”

“Cancer researchers confirm brain tumor genetic subtype informs treatment, predicts outcome”
(July 6) EurekAlert! reports, “Research confirms that determining the genetic composition of brain cancers can better inform doctors and patients for treatment options and prognosis.” This reference links to a non-governmental website

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Genomics in Scientific Literature
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DNA polymorphisms and renal disease: a critical appraisal of studies presented at the annual ERA/EDTA and ASN conferences in 2004 and 2005
Mondry A, et al.
Nephrol Dial Transplant 2006 Jul

Factors associated with the incompliance with mammogram screening among individuals with a family history of breast cancer or ovarian cancer
Wu H, et al.
Breast Cancer Res Treat 2006 Jul

Quantifying bias due to allele misclassification in case-control studies of haplotypes
Govindarajulu US, et al.
Genet Epidemiol 2006 Jul

Genetic disorders among Palestinian Arabs. 4: Genetic clinics in the community
Zlotogora J, et al.
Am J Med Genet A 2006 Jul

Prospective evaluation of prostate cancer screening in men with a family history of the disease
Paiss T, et al.
Urologe A 2006 Jul

Ethical issues arising from the participation of children in genetic research
Burke W & Diekema DS
J Pediatr 2006 Jul;149(1S):S34-S38

alpha1-Antitrypsin Deficiency: Situation in Spain and Development of a Screening Program
De la Roza C, et al.
Arch Bronconeumol 2006 Jun;42(6):290-8

Risk assessment in relatives of gastric cancer patients: hyperproliferation, genetics, and Helicobacter pylori infection
Ignasi Elizalde J & Pique JM
Eur J Gastroenterol Hepatol 2006 Aug;18(8):877-9

Long QT syndrome: genes, mechanisms and risks; indication for genetic family screening?
Bundgaard H, et al.
Ugeskr Laeger 2006 Jun;168(26-32):2537-42

Why disclosure of genetic tests for health insurance should be voluntary
Smith R & Raithatha N
J Health Serv Res Policy 2006 Jul;11(3):184-6

Institutionalized paternalism? Stakeholders' views on public access to genetic testing
Carter S, et al.
J Health Serv Res Policy 2006 Jul;11(3):155-61

Genetic susceptibility for cancer in childhood
Schmiegelow K
Ugeskr Laeger 2006 Jun;168(24):2373-6

Familial colorectal cancer
Sunde LE, et al.
Ugeskr Laeger 2006 Jun;168(24):2369-73

Inherited breast and ovarian cancers
Gerdes AM & Ejlertsen B
Ugeskr Laeger 2006 Jun;168(24):2367-9

Genetic counselling in monogenic cancer syndromes
Brondum-Nielsen K & Gerdes AM
Ugeskr Laeger 2006 Jun;168(24):2350-4

Social and family considerations in genetic counselling
Svendsen MN & Koch L
Ugeskr Laeger 2006 Jun;168(24):2348-50

PARK8 LRRK2 Parkinsonism
Haugarvoll K & Wszolek ZK
Curr Neurol Neurosci Rep 2006 Jun;6(4):287-94

The genetics of melanoma
Bishop JN, et al.
Br J Hosp Med (Lond) 2006 Jun;67(6):299-304

Genetics and pathophysiology of mental retardation
Chelly J, et al.
Eur J Hum Genet 2006 Jun;14(6):701-13

The genetics of developmental dyslexia
Williams J & O'Donovan MC
Eur J Hum Genet 2006 Jun;14(6):681-9

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending July 12, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

CAGC 2006 Annual Education Conference 
September 28-30, 2006 ~ Winnipeg, Manitoba

 

The Learning Healthcare System - Workshop 1
July 20-21, 2006 - Institute of Medicine, Washington DC

   
  11th International Congress of Human Genetics This reference links to a non-governmental website
August 6-10, 2006 ~ Brisbane, Australia
   
  The 8th International Meeting on Human Genome Variation and Complex Genome Analysis
September 14-16, 2006 ~ Hong Kong, China
   
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Let's Go Surfing
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OECD Invites Public Comment on Genetic Testing Guidelines This reference links to a non-governmental website (last accessed 3/2007)
Patients’ groups, health authorities, genetic testing laboratories and others involved in the molecular testing field are invited to comment before 4 September via e-mail at: sti.bioQAguidelines@oecd.org or through the website.

Genetic Test for Cancer you will need a free Acrobat reader to view this file
Technology Assessment prepared for the Agency for Healthcare Research and Quality

Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Evidence Synthesis you will need a free Acrobat reader to view this file
Evidence Synthesis prepared for the Agency for Healthcare Research and Quality

Family history and colorectal cancer risk This reference links to a non-governmental website
A new paper by members of the Public Health Genetics Unit in Cambridge provides a meta‑analysis of the relative risks of developing colorectal cancer among individuals with a family history of the disease, produced by a systematic review of published literature on familial colorectal cancer risk [Butterworth et al. (2006) Eur J Cancer 42(2), 216-27].

Asthma Genomics Workplan
The workplan was the result of a workshop conducted with asthma and genomics stakeholders in April 2006 in West Valley City, UT.  Participants developed a list of priority activities in pharmacogenomics, family health history, and ethical, legal, and social issues (ELSI) that will be completed over the next 3-5 years.

Public Health Genetics Unit, UK, Newsletter, July 2006 This reference links to a non-governmental website
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: July 13, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics