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 Thursday, January 19, 2006     Volume 16   Number 3  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Nature Genetics article: A road map for efficient & reliable human genome epidemiology

Commentary: A road map for efficient and reliable human genome epidemiology This reference links to a non-governmental website
John P A Ioannidis, Marta Gwinn, Julian
Little, et al.    
Nature Genetics 38, 305 (2006)
“Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases."

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CDC Announcements
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EGAPP Meeting Agenda
The next EGAPP Working Group meeting is scheduled for February 13-14, 2006 in Atlanta, Georgia. The preliminary agenda is posted and observers are welcome at the open session on Monday.
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EPHX1 Polymorphisms and the Risk of Lung Cancer
Chikako Kiyohara, et al.

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Diagnosis And Treatment Of Idiopathic Pulmonary Fibrosis Improves With Advanced Genomics And Proteomics” This reference links to a non-governmental website
(January 13) Medical News Today reports, “In an article in the Jan 15 issue of the American Journal of Respiratory Critical Care Medicine, University of Pittsburgh researchers report that a serious, life-threatening form of pulmonary fibrosis, called idiopathic pulmonary fibrosis, lacks all the hallmarks of inflammation and is probably unnecessarily treated with anti-inflammatory drugs.”

“New microRNA mechanism for regulating brain function” This reference links to a non-governmental website
(January 18) News Medical.net  reports, “Non-coding regions of the genome - those that don't code for proteins - are now known to include important elements that regulate gene activity.”

“Utah researchers confirm chromosome may harbor autism gene” This reference links to a non-governmental website
(January 17) EurekAlert! reports, “Using technology that allows DNA from thousands of genes to be collected and surveyed on a 3 x 1½-inch chip, University of Utah medical researchers have confirmed that a region on a single chromosome probably harbors a gene that causes autism.”

“USC scientists link variations in growth-factor gene to risk of prostate cancer” This reference links to a non-governmental website
(January 17) EurekAlert! reports, “Two variations in the gene for insulin-like growth factor I (IGF-1) are linked to an increased risk of prostate cancer, according to research performed by scientists from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, and the University of Hawaii.”

“Iceland study finds important diabetes gene”
(January 16) Reuters Health reports, “A single genetic change could predispose close to 40 percent of the population to type-2 diabetes, researchers said on Sunday.”

“Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis” This reference links to a non-governmental website
(January 16) News-Medical.Net reports, “Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease.”

“A FAT chance of becoming manic-depressive”
(January 13) Garvan Institute reports, “A collaboration, led by Sydney scientists at the Garvan Institute of Medical Research and University of New South Wales, has discovered  the first risk gene specifically for bipolar disorder, also known as manic-depressive illness.”

“Gene Sequencing Information On Human Viruses From First Two Fatal Human Cases In The Turkish Bird Flu Outbreak” This reference links to a non-governmental website
(January 13) Medical News Today reports, “The WHO Collaborating Centre for Reference and Research on influenza at the MRC National Institute for Medical Research in Mill Hill, London, has today completed genetic and antigenic analyses of viruses recovered from the first two fatal human cases in the Turkish outbreak.”

“Molecule does more than slice and dice RNA” This reference links to a non-governmental website
(January 12) EurekAlert! reports, “A team of Howard Hughes Medical Institute (HHMI) scientists has peeled back some of the mystery of how cells are able to turn off genes selectively to control critical events of development.”

“Supersized 'island' of resistance genes discovered in an infectious bacterium” This reference links to a non-governmental website
(January 12) EurekAlert! reports, “Researchers have discovered a cluster of 45 genes coding for antibacterial drug resistance in the bacterium, Acinetobacter baumannii, a major cause of hospital-acquired infections worldwide. The study was reported in the open-access journal PLoS Genetics.”

“Genes affect benefits of breast cancer drug”
(January 12) Medline Plus reports, “The gene for an enzyme called cytochrome P450 2D6 (CYP2D6) influences how well the breast cancer drug tamoxifen works and whether hot flashes are likely to occur, according to a report in the Journal of Clinical Oncology.”

 
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Genomics in Scientific Literature
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The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis
Lewis SJ, et al.
Mol Psychiatry 2006 Jan        

Evaluating Statistical Significance in Two-Stage Genomewide Association Studies
Lin DY
Am J Hum Genet 2006 Jan;78(3)

Communication and risk presentation in genetic counseling Development of a checklist
Fransen M, et al.
Patient Educ Couns 2006 Jan

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study
Verkooijen HM, et al.
Br J Cancer 2005 Dec

Association of CYP2E1 gene polymorphism with predisposition to cancer development
Danko IM & Chaschin NA
Exp Oncol 2005 Dec;27(4):248-56

Type 1 diabetes associated autoimmunity: Natural History, Genetic Associations and Screening
Barker JM
J Clin Endocrinol Metab 2006 Jan

Pharmacogenomics of acute leukemia
Cheok MH, et al.
Annu Rev Pharmacol Toxicol 2006 Feb;46:317-53

Understanding genetics: a primer for occupational health practice
Wright L
AAOHN J 2005 Dec;53(12):534-42; quiz 543-4

Health and employment practices: ethical, legal, and social implications of advances in toxicogenomics
Weinstein M, et al.
AAOHN J 2005 Dec;53(12):529-33

Occupational and environmental health in the 21st century: the new frontier in genetics and disease prevention
Rischitelli DG, et al.
AAOHN J 2005 Dec;53(12):522-8

Reliability of self-reported family history of cancer in a large case-control study of lymphoma
Chang ET, et al.
J Natl Cancer Inst 2006 Jan;98(1):61-8

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 18, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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New this week

Systems Biology: Global Regulation Of Gene Expression This reference links to a non-governmental website (last accessed 2/2008)
March 23-26, 2006 ~ Cold Spring Harbor, NY

CDC sponsored event
Mendelian Randomization: How Can Genetic Epidemiology Contribute to Understanding Environmental Causes of Disease?
February 3, 2006 ~ Atlanta, GA
   
The TGF-ß Family in Cancer and Other Diseases
February 8-12, 2006 ~ La Jolla, CA
   
New this week Chromatin Structure & Function Gordon Research Conference This reference links to a non-governmental website
May 21-26, 2006 ~ Barga, Italy
   
New this week Dynamic Organization of Nuclear Function This reference links to a non-governmental website (last accessed 2/2008)
September 27- October 1, 2006 ~ Cold Spring Harbor, NY
   
New this week Pharmacogenomics This reference links to a non-governmental website (last accessed 2/2008)
November 15-18, 2006 ~ Cold Spring Harbor, NY
   
New this week

From Genomes to Protective Antigens: Designing Vaccines This reference links to a non-governmental website
November 15-17, 2006 ~ Prague, Czech Republic

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Let's Go Surfing
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Harvard Medical School- Partners Healthcare Center for Genetics and Genomics (HPCGG) This reference links to a non-governmental website
The HPCGG was launched in the fall of 2001 with the mission of promoting genomics and genetics in research and clinical medicine.

Utah Chronic Disease Genomics Program
Located at the Utah Department of Health in the Bureau of Health Promotion, the intention of this program is to develop infrastructure and leadership capacity to integrate genomics into public health, with a focus on chronic disease.

MedBioWorld This reference links to a non-governmental website
A collection of Genetics, Genomics & Biotechnology Journals

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: January 19, 2006 (archived document)
Page last updated: November 6, 2007
Content Source: National Office of Public Health Genomics