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 Thursday, August 10, 2006     Volume 17   Number 6  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
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Welcome to the National Office of Public Health Genomics
As of July 24, 2006, the CDC has changed the name of our office to the National Office of Public Health Genomics.

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CDC Announcements
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CDC sponsored material

CDC Science Ambassador Program: High school lesson plan topics related to public health genomics

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At-Home Genetic Tests: A Healthy Dose of Skepticism May Be the Best Prescription
Federal Trade Commission Consumer Alert

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Talk to Your Doctor or Healthcare Practitioner About Home Genetic Tests
Federal Trade Commission Press Release

CDC sponsored material HuGE What's New
August 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“CDC puts genetic sequences of about 40 human H5N1 viruses into public domain” This reference links to a non-governmental website
(Aug 7) MediResource reports, “Scientists at the U.S. Centers for Disease Control have placed the genetic blueprints of about 40 H5N1 viruses isolated from human bird flu cases in Indonesia into one public access database.”

“Scientists have pinpointed two genes that lead to schizophrenia and manic depression” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 10) The Copenhagen Post Online reports, “Researchers at Aarhus University's Institute for Human Genetics have discovered two genes that are catalysts for mental illness, particularly schizophrenia and manic depression, daily newspaper Berlingske Tidende reported Thursday.”

“New research examines genetics of successful aging” This reference links to a non-governmental website
(Aug 10) EurekAlert! reports, “Scientists have identified genes related to reaching age 90 with preserved cognition, according to a study published in the September issue of the American Journal of Geriatric Psychiatry.”

“Scientists hail breast cancer breakthrough” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 9) Herald Sun reports, “AUSTRALIAN scientists have helped unearth the biggest breast cancer breakthrough in years - the first discovery of common genes linked to the disease.”

“MatBase -- A new transcription factor knowledge base released by Genomatix” This reference links to a non-governmental website
(Aug 8) EurekAlert! reports, “Genomatix Software GmbH, a pioneer and leader in the analysis of eukaryotic transcriptional regulation, releases MatBase, a knowledge base of transcription factors (TF).”

“Unique Huntington's study moves forward” This reference links to a non-governmental website
(Aug 8) EurekAlert! reports, “Doctors have completed the first step of a unique medical research study, evaluating 1,001 individuals at risk of developing Huntington's disease who do not know – nor do they want to know – whether they carry the genetic defect that causes the condition.”

“Evidence of a genetic risk factor for Parkinson's disease” This reference links to a non-governmental website
(Aug 8) News-Medical.Net reports, “A Mayo Clinic-led international research collaboration - one of the largest studies of its kind - provides strong evidence that a genetic risk factor may account for 3 percent of the cause of Parkinson's disease.”

“New study reveals Rett syndrome can strike males” This reference links to a non-governmental website
(Aug 8) EurekAlert! reports, “Report co-author Dr Helen Leonard, who heads the Australian Rett Syndrome Study at the Telethon Institute for Child Health Research, says the finding means that testing for the genetic disorder should be considered in some baby boys who develop progressive serious neurological problems.”

“11th International Congress of Human Genetics” This reference links to a non-governmental website
(Aug 8) Rare Diseases.com reports, “Brisbane, Australia, is the site of the 11th International Congress of Human Genetics from August 6-10, 2006.”

“Genetic databank to catalogue WA residents” This reference links to a non-governmental website
(Aug 8) ABC News Online reports, “Researchers plan to collect blood samples and health information from every person in Western Australia over the next few years in a move they say will create the world's biggest human genetic databank.”

“'Warrior gene' blamed for Maori violence” This reference links to a non-governmental website
(Aug 8) ninemsn.com reports, “New Zealand Maori carry a "warrior" gene which makes them more prone to violence, criminal acts and risky behaviour, a scientist has controversially claimed.”

“DNA overwinds when stretched” This reference links to a non-governmental website
(Aug 8) News-Medical.Net reports, “Most of us are familiar with the winding staircase image of DNA, the repository of a biological cell's genetic information. But few of us realize just how tightly that famous double helix is wound.”

“Genetic breakthroughs usher in personalized medicine” This reference links to a non-governmental website
(Aug 6) PalmBeachPost.com reports, “Matthew Green shaves, does his own laundry and can cook. He wiped down tables at the Beverly Hills Cafe in his hometown of Pembroke Pines until recently.”

“Genetics is a very strong component of obesity” This reference links to a non-governmental website
(Aug 6) News-Medical.Net reports, “Nearly 6 percent of morbidly obese children and adults have a genetic defect that keeps them feeling like their stomach is running on empty, no matter how much they have eaten.”

“Reggie: I Fell Ill and Grew 20 Years Younger” This reference links to a non-governmental website
(Aug 6) RedOrbit reports, “A GRANDAD suffering from a rare disease has found a bizarre side effect to his treatment - it makes him look 20 years younger.”

“BRIT1 gene identified as protector of DNA” This reference links to a non-governmental website
(Aug 6) RxPG News reports, “A single gene plays a pivotal role launching two DNA damage detection and repair pathways in the human genome, suggesting that it functions as a previously unidentified tumor suppressor gene, researchers at The University of Texas M. D. Anderson Cancer Center report in Cancer Cell.”

“Rapid Integration Site Mapping” This reference links to a non-governmental website
(Aug 5) Pharmalicensing.com reports, “This invention can be used to provide rapid, cost-effective screening of cells treated with retroviruses for gene therapy.”

“Genetic Evidence Supports Endometriosis as Ovarian Cancer Precursor” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 4) Cancer page.com reports, “The results of a study provide "convincing" molecular genetic evidence that endometriosis is a precursor to ovarian cancer, UK and US collaborators report in the August 1st issue of the International Journal of Cancer.”

“Neural stem cells derived from human embryonic stem cells carry abnormal gene expression” This reference links to a non-governmental website
(Aug 4) EurekAlert! reports, “Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.”

“Researchers identify gene as protector of DNA, enemy of tumors” This reference links to a non-governmental website
(Aug 3) EurekAlert! reports, “A single gene plays a pivotal role launching two DNA damage detection and repair pathways in the human genome, suggesting that it functions as a previously unidentified tumor suppressor gene, researchers at The University of Texas M. D. Anderson Cancer Center report in Cancer Cell.”

“Genetic predisposition may raise risk of Emanuel syndrome” This reference links to a non-governmental website
(Aug 3) MedicineNews.net reports, “A report, published in the journal Science by researchers at The Children's Hospital of Philadelphia and the University of Pennsylvania analyzes genetic predisposition to the translocation t ( 11;22 ), a swapping of genetic material between chromosomes 11 and 22.”

“Finding the key of the genetic door to a cancer cure” This reference links to a non-governmental website
(Aug 3) Cape Argus reports, “Genomic science is dramatically widening the scope for understanding cancers, but breakthrough cures should be expected within generations, not years, says Eric Lander, one of the leading scientists in this field.”

“Genetics researchers identify second gene that gives rise to Alagille syndrome” This reference links to a non-governmental website
(Aug 2) News-Medical.Net reports, “In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs.”

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Genomics in Scientific Literature
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CDC sponsored material  Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases
Ioannidis JP, et al.
Am J Epidemiol 2006 Aug

GeneTests: an online genetic information resource for health care providers
Pagon, R. A.
J Med Libr Assoc 2006 Jul;94: 343-8

Recent advances in the immunogenetics of human type 1 diabetes
Onengut-Gumuscu S & Concannon P
Curr Opin Immunol 2006 Jul

Genetic information in the diagnosis and treatment of hypertension
Tomaszewski M, et al.
Curr Hypertens Rep 2006 Jul;8(4):309-16

Knowledge of breast cancer and its risk and protective factors among women in Riyadh
Alam AA
Ann Saudi Med 2006 Jul-2006 Aug;26(4):272-7

At risk for Huntington disease: The PHAROS (Prospective Huntington At Risk Observational Study) cohort enrolled
Arch Neurol 2006 Jul;63(7):991-6

Challenges and strategies of the Genetics Home Reference
Mitchell JA, et al.
J Med Libr Assoc 2006 Jul;94(3):336-42

Molecular genetics of febrile seizures
Nakayama J & Arinami T
Epilepsy Res 2006 Aug

Single nucleotide polymorphisms and breast cancer: not yet a success story
Tamimi RM
Breast Cancer Res 2006 Jul;8(4):108

Genetic association studies in epilepsy pharmacogenomics: lessons learnt and potential applications
Depondt C & Shorvon SD
Pharmacogenomics 2006 Jul;7(5):731-45

Family History
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“Genetic Test for Diabetes May Gauge Risk, but Is the Risk Worth Knowing?” This reference links to a non-governmental website
(Aug 8) New York Times reports, “Like her mother and grandmother, my mother had Type 2 diabetes.”

“Genetic Findings Shed Light On OCD” This reference links to a non-governmental website
(Aug 3) QualityHealth.com reports, “A newly identified genetic factor may explain how and why obsessive-compulsive disorder (OCD) runs in families, two new studies conclude.”

Personalized genomic medicine: a future prerequisite for the prevention of coronary artery disease
Roberts R & Stewart AF
Am Heart Hosp J 2006 Summer;4(3):222-7

CHEK2 c.1100delC may not contribute to genetic background of hereditary breast cancer from Shanghai of China
Song C, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Aug;23(4):443-5

Genetic Testing
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“Obama bill could jumpstart the setting of sound genetic public policy” This reference links to a non-governmental website
(Aug 4) Genetics & Public Policy Center reports, “Sen. Barack Obama (D-IL) yesterday introduced legislation to improve development and appropriate use of genetic tests in the United States, the Genetics and Public Policy Center has learned.”

“Genetic test aids lung cancer fight” This reference links to a non-governmental website
(Aug 10) The Boston Globe reports, “Scientists have developed a powerful new genetic test to determine which lung cancer patients should get chemotherapy, saying the advance could save thousands of lives every year and heralds the growing importance of genetic profiling in cancer care.”

“Home genetic test for schizophrenia” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 7) philly.com reports, “Nearly 1 percent of all Americans, 2.4 million people, have schizophrenia. An estimated 5.7 million have bipolar disorder.”

“Genetic test may sound false alarm” This reference links to a non-governmental website
(Aug 6) ContraCostaTimes.com reports, “Firms make medical predictions using results from home DNA kit, but investigators question accuracy.”

“Screening for Hemochromatosis” This reference links to a non-governmental website
(Aug) AHRQ reports, “The U.S. Preventive Services Task Force has issued a new recommendation against routine genetic screening for hereditary hemochromatosis in the asymptomatic general population.  (D recommendation)”

GeneTests: an online genetic information resource for health care providers
Pagon, R. A.
J Med Libr Assoc 2006 Jul;94: 343-8

State newborn screening in the tandem mass spectrometry era: more tests, more false-positive results
Tarini BA, et al.
Pediatrics 2006 Aug;118(2):448-56

Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe
van den Akker-van Marle ME, et al.
Pharmacogenomics 2006 Jul;7(5):783-92

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 9, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

Beyond the Genome ... Beyond the Individual: Genomics and Public Health This reference links to a non-governmental website
National Society of Genetic Counselors Short Course 2006
November 9-10, 2006 ~ Nashville, TN

New This Week

Xeroderma Pigmentosum and Other Diseases of Human Premature Aging and DNA Repair: Molecules to Patients This reference links to a non-governmental website (last accessed 2/2008)
September 5-8, 2006 ~ Lansdowne, VA

   
  PXE International 2006 Meeting
September 29 – October 1, 2006 ~ Washington, DC
   
New This Week Mechanisms and Consequences of Chromosomal Translocations This reference links to a non-governmental website
October 22-24, 2006 ~ Warrenton, VA
   
New This Week International Research Conference on Ankyloblepharon-Ectodermal Dysplasia-Cleft Lip/Palate AEC Syndrome This reference links to a non-governmental website (last accessed 2/2008)
November 8-10, 2006 ~ Houston, TX
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Let's Go Surfing
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Genetics Home Reference
Genetics Home Reference is the National Library of Medicine's website for consumer information about genetic conditions and the genes or chromosomes responsible for those conditions.

Genomics at the FDA

Department of Genetics This reference links to a non-governmental website
Kassel University, Germany

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: August 10, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics